September 10 2009
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OUR TOP STORIES
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International Society for Stem Cell Research reading list
A compilation of papers covered in talks at the 7th annual meeting
http://links.ealert.nature.com/ctt?kn=38&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
Q&A with Melissa Carpenter: making stem cells for many, safely
Barriers must be overcome to move cell therapies from the laboratory to the clinic
http://links.ealert.nature.com/ctt?kn=10&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
Stem cell projects falter (Nature subscription required)
Ailing economy leaves California struggling to build research labs.
http://links.ealert.nature.com/ctt?kn=4&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
Top scientist's industry move heralds stem-cell shift (Nature subscription required)
Stephen Minger tells Nature why he is leaving academia.
http://links.ealert.nature.com/ctt?kn=5&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
Japan relaxes human stem cell rules (Nature subscription required)
But scientists fear it is too late to regain lost ground.
http://links.ealert.nature.com/ctt?kn=22&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
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ARTICLES KEYING OFF RECENT PUBLICATIONS
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Flab and freckles could advance stem cell research
Alternative tissues shown to yield reprogrammed cells aplenty
Sun, N. et al. Proc. Natl. Acad. Sci. USA advance online publication doi:10.1073/pnas.0908450106 (2009)
Utikal, J., Maherali, N., Kulalert, W. & Hochedlinger, K. J. Cell Sci. advance online publication doi:10.1242/jcs.054783 (2009)
http://links.ealert.nature.com/ctt?kn=21&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
What does Nanog do?
In embryos and induced pluripotent stem cells, Nanog sets the ground state of pluripotency
Silva, J. et al. Cell 138, 722-737 (2009).
http://links.ealert.nature.com/ctt?kn=37&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
Stem cells delay disease onset in mice with neurodegenerative disease
Transplanted cells from biotech company detoxify poisoned brains, at least for awhile
Tamaki, S. J. et al. Cell Stem Cell 5, 310-319 (2009).
http://links.ealert.nature.com/ctt?kn=36&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
iPS cells used to probe rare neurodegenerative disease
Study investigates what goes wrong in familial dysautonomia and assesses potential treatments
Lee, G. et al. Nature advance online publication, doi:10.1038/nature08320 (19 August 2009).
http://links.ealert.nature.com/ctt?kn=18&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
DNA swap could avoid inherited diseases
Experiments in monkeys show how mothers can avoid passing on mitochondrial DNA mutations to their offspring. (Nature subscription required)
Tachibana, M. et al. Nature advance online publication doi:10.1038/nature08368 (2009).
http://links.ealert.nature.com/ctt?kn=24&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
A screen for cancer killers (Nature subscription required)
Method identifies drugs that target the cells behind cancer growth.
Gupta, P. B. et al. Cell 138, 645-659 (2009).
http://links.ealert.nature.com/ctt?kn=23&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
Please do not eat the stem cells
Cancers copy normal stem cells to avoid phagocytosis
Jaiswal, S. et al. Cell 138, 271-285 (2009).
Majeti, R. et al. Cell 138, 286-299 (2009).
Chan, K. S. et al. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.0906549106 (published online 4 August 2009).
http://links.ealert.nature.com/ctt?kn=19&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
Zinc fingers splice genes in human pluripotent stem cells
Technique will make genetic engineering easier
Hockemeyer, D. et al. Nature Biotechnol. advance online publication, doi:10.1038/nbt.1562 (13 August 2009).
http://links.ealert.nature.com/ctt?kn=16&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
p53 prevents pluripotency
The guardian of the genome also blocks reprogramming
Hong, H. et al. Nature 460, 1132-1135 (2009)
Kawamura, T. et al. Nature 460, 1140-1144 (2009)
Utikal, J. et al. Nature 460, 1145-1148 (2009)
Li, H. et al. Nature 460, 1136-1139 (2009)
Marión, E. et al. Nature 460, 1149-1153 (2009)
http://links.ealert.nature.com/ctt?kn=17&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
Induced pluripotent stem cells, down to one factor
Human neural stem cells reprogrammed with only OCT4
Kim, J. B. et al. Nature advance online publication, doi:10.1038/nature08436 (28 August 2009).
http://links.ealert.nature.com/ctt?kn=35&m=34029294&r=MTc2NjM3NTc5MQS2&b=2&j=NTc4MTAyNDAS1&mt=1&rt=0
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