October 2009 Volume 10 Number 10
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This month's FEATURED article:
Mechanisms of Polycomb gene silencing: knowns and unknowns
Jeffrey A. Simon and Robert E. Kingston
p697 | doi:10.1038/nrm2763
http://links.ealert.nature.com/ctt?kn=15&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
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From the editors
p651 | doi:10.1038/nrm2775
http://links.ealert.nature.com/ctt?kn=50&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Small RNAs: Keeping let-7 young
p652 | doi:10.1038/nrm2776
http://links.ealert.nature.com/ctt?kn=55&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Cell signalling: Free ubiquitin!
p653 | doi:10.1038/nrm2765
http://links.ealert.nature.com/ctt?kn=53&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
JOURNAL CLUB
The matrix revolutions
p653 | doi:10.1038/nrm2769
http://links.ealert.nature.com/ctt?kn=41&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Technology: GTPase activation at the leading edge
p654 | doi:10.1038/nrm2768
http://links.ealert.nature.com/ctt?kn=37&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
DNA replication: Unwinding maxicircle DNA
p654 | doi:10.1038/nrm2772
http://links.ealert.nature.com/ctt?kn=59&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Systems biology: Cell biology put in context
p655 | doi:10.1038/nrm2773
http://links.ealert.nature.com/ctt?kn=65&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Chromatin: A variant function for H2AZ
p656 | doi:10.1038/nrm2770
http://links.ealert.nature.com/ctt?kn=63&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Small RNAs: RISCs hitch a ride
p656 | doi:10.1038/nrm2771
http://links.ealert.nature.com/ctt?kn=69&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
IN BRIEF
Cell death | Cell death | Cytoskeleton
p656 | doi:10.1038/nrm2779
http://links.ealert.nature.com/ctt?kn=31&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
IN THE NEWS
Reconstructed egg for IVF
p657 | doi:10.1038/nrm2778
http://links.ealert.nature.com/ctt?kn=78&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
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REVIEWS
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Ubiquitin-binding domains - from structures to functions
Ivan Dikic, Soichi Wakatsuki and Kylie J. Walters
p659 | doi:10.1038/nrm2767
Ubiquitin-binding domains (UBDs) are modular elements that bind
non-covalently to the protein modifier ubiquitin. Recent structures
of ubiquitin-UBD complexes at atomic-level resolution reveal some of
the mechanisms that underlie the versatile functions of ubiquitin
in vivo.
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Systems biology of stem cell fate and cellular reprogramming
Ben D. MacArthur, Avi Ma'ayan and Ihor R. Lemischka
p672 | doi:10.1038/nrm2766
Stem cell differentiation and the maintenance of self-renewal are
intrinsically complex processes. They require the coordinated and
dynamic expression of hundreds of genes and proteins, in precise
response to external signalling cues. Systems biology approaches are
helping to dissect this complexity.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Kinesin superfamily motor proteins and intracellular transport
Nobutaka Hirokawa, Yasuko Noda, Yosuke Tanaka and Shinsuke Niwa
p682 | doi:10.1038/nrm2774
Kinesins are molecular motors that directionally transport various
cargos, including membranous organelles, protein complexes and mRNAs.
The mechanisms by which kinesins recognize, bind and unload cargo, and
also regulate processes such as higher brain function, tumour suppression
and developmental patterning, are becoming clear.
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Mechanisms of Polycomb gene silencing: knowns and unknowns
Jeffrey A. Simon and Robert E. Kingston
p697 | doi:10.1038/nrm2763
Polycomb group (PcG) proteins constitute a conserved gene silencing
system with widespread roles in multicellular development, stem cell
biology and cancer. Recent studies suggest that PcG-mediated gene
silencing may involve histone modifications and a possible block in
transcriptional elongation.
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Structural and functional constraints in the evolution of protein
families
Catherine L. Worth, Sungsam Gong and Tom L. Blundell
p709 | doi:10.1038/nrm2762
Amino acid substitutions in divergent protein families reflect both
Darwinian selection and neutral evolution. The latter operates within
structural and functional constraints and arises from the need to
conserve protein architecture and interactions that are important for
the survival of the organism.
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Protein denitrosylation: enzymatic mechanisms and cellular functions
Moran Benhar, Michael T. Forrester and Jonathan S. Stamler
p721 | doi:10.1038/nrm2764
Protein denitrosylation, the removal of nitric oxide groups from Cys thiols,
was once considered to be a spontaneous event. Now, the discovery of
denitrosylases, the enzymes that catalyse this process, is advancing
our understanding of redox-based signalling in normal and aberrant
cellular functions.
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34064362&r=MTc2NzYzNjQ2NgS2&b=2&j=NTgzNTY4OTAS1&mt=1&rt=0
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Nature Genetics presents a Focus on copy number variation highlighting
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