October 2009 Volume 6 Number 10
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NEW from Nature Reviews Cardiology: Molecular Imaging Series
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Reviews and Perspective articles from leading specialists in
cardiovascular imaging.
The Molecular Imaging Series covers every aspect of the visualization
of physiological and pathophysiological processes at the cellular and
molecular levels. With each issue of Nature Reviews Cardiology until
spring 2010, a molecular-imaging-focused paper will be published in
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EDITORIAL
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Lipid lowering: education is key
Valentin Fuster and Bryony M. Mearns
p609 | doi:10.1038/nrcardio.2009.164
http://links.ealert.nature.com/ctt?kn=3&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Cardiomyopathies: New insights into hypertrophic cardiomyopathy
p611 | doi:10.1038/nrcardio.2009.147
http://links.ealert.nature.com/ctt?kn=6&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Cardiomyopathy and heart failure: Cardiac death in children
p612 | doi:10.1038/nrcardio.2009.143
http://links.ealert.nature.com/ctt?kn=15&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
New gene for dilated cardiomyopathy
p612 | doi:10.1038/nrcardio.2009.145
http://links.ealert.nature.com/ctt?kn=19&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Anticoagulation therapy: Target INRs for cardiac indications
p613 | doi:10.1038/nrcardio.2009.142
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Hypertension: A new drug for pulmonary hypertension
p613 | doi:10.1038/nrcardio.2009.144
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NT-proBNP levels: renal involvement?
p613 | doi:10.1038/nrcardio.2009.146
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Heart failure: Continuous-flow rotary pump LVADs-a good option?
p614 | doi:10.1038/nrcardio.2009.148
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Acute coronary syndromes: Statins and coronary plaque progression
p614 | doi:10.1038/nrcardio.2009.149
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NEWS AND VIEWS
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Stem cells: Bone marrow cell therapy for MI-goal achieved?
Helmut Drexler and Kai C. Wollert
p615 | doi:10.1038/nrcardio.2009.158
Cell therapy for myocardial infarction has received widespread attention.
Although short-term effects have been encouraging, Yousef et al. now
report substantial benefit of bone marrow mononuclear cells over 5 years
of follow-up in an open-label series of 62 patients. Long-term follow-up
of randomized trials is eagerly awaited and novel approaches of cell
therapy are currently under investigation.
http://links.ealert.nature.com/ctt?kn=30&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Vascular disease: Is AAA screening worth the cost?
Frank A. Lederle
p616 | doi:10.1038/nrcardio.2009.161
Ultrasonographic screening of older men to detect abdominal aortic
aneurysms has been added to the list of programs supported by the National
Health Service in England and Scotland, and by Medicare in the US. Two
articles in the British Medical Journal addressing the cost-effectiveness
of this practice have provided markedly discordant results.
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Valvular disease: Transcatheter aortic valve implantation-time for
wider use?
Thomas Walther and Michael A. Borger
p618 | doi:10.1038/nrcardio.2009.159
Transcatheter aortic valve implantation has evolved as a viable
therapeutic option for high-risk, elderly patients with symptomatic aortic
stenosis in select cardiac centers with experience of the procedure. In
this article we consider the findings reported by Webb et al. and discuss
current criteria for selection of patients, technical features, clinical
results, and future developments in this rapidly advancing area.
http://links.ealert.nature.com/ctt?kn=44&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Acute coronary syndromes: Oral factor Xa inhibitors in acute coronary
syndromes
Luke Tapp, Ben Wrigley and Gregory Y. H. Lip
p619 | doi:10.1038/nrcardio.2009.160
Factor Xa inhibitors, a new class of oral anticoagulants, have been
evaluated in the phase II ATLAS ACS-TIMI 46 and APPRAISE trials. Addition
of these agents to standard therapy has tended to reduce the incidence
of adverse cardiovascular events at the expense of a dose-dependent
increase in the risk of bleeding complications.
http://links.ealert.nature.com/ctt?kn=42&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
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REVIEWS
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Vitamin D status and arterial hypertension: a systematic review
Stefan Pilz, Andreas Tomaschitz, Eberhard Ritz and Thomas R. Pieber
Published online: 18 August 2009
p621 | doi:10.1038/nrcardio.2009.135
In this extensive Review, Stefan Pilz and colleagues discuss the potential
mechanisms by which vitamin D might affect blood pressure and explore the
clinical evidence for an association between vitamin D and arterial
hypertension. The authors also make recommendations for vitamin D
supplementation in patients with hypertension and 25-hydroxyvitamin D
levels below target values.
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Cardiovascular pharmacogenomics and individualized drug therapy
Naveen L. Pereira and Richard M. Weinshilboum
Published online: 25 August 2009
p632 | doi:10.1038/nrcardio.2009.154
Individualized drug therapy requires physicians to be able to accurately
predict an individual's response to a drug. 'Pharmacogenetics' is the
study of the role of inheritance in variation in drug response phenotypes.
Pharmacogenetics is now moving genome-wide to become 'pharmacogenomics'.
This article reviews the development, promise and challenges of
pharmacogenomics, using examples of drugs used to treat or prevent
cardiovascular disease.
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Success and failure of vaccines against renin-angiotensin system
components
Morris J. Brown
Published online: 25 August 2009
p639 | doi:10.1038/nrcardio.2009.156
Treatment of hypertension is associated with a reduction in the risk of
cardiovascular complications such as stroke. In this Review, Morris Brown
discusses vaccines that target components of the renin-angiotensin system
as a potential strategy not only for treating hypertension, but for
preventing the development of treatment-resistant hypertension.
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Imaging myocardial angiogenesis
Joanna J. Wykrzykowska, Timothy D. Henry, John R. Lesser and Robert S.
Schwartz
Published online: 08 September 2009
p648 | doi:10.1038/nrcardio.2009.157
Myocardial angiogenesis occurs in response to hypoxia in ischemic
tissues. This Review discusses imaging techniques that can be used to
assess the effectiveness of exogenous angiogenic agents in promoting
the growth of collateral vessels in ischemic myocardium.
Abstract: http://links.ealert.nature.com/ctt?kn=72&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Assessment of specialists in cardiovascular practice
Kamran Ahmed, Hutan Ashrafian, George B. Hanna, Ara Darzi and Thanos
Athanasiou
Published online: 01 September 2009
p659 | doi:10.1038/nrcardio.2009.155
Ongoing medical education and recertification of specialists is important
in minimizing medical errors and ensuring that patients receive quality
care. This Review discusses the processes by which cardiovascular
specialists are assessed in different geographical regions.
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=34064451&r=MTc2NDI1MzEzNAS2&b=2&j=NTgzNTc5NjQS1&mt=1&rt=0
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