August 2009 Volume 6 Number 8
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RESEARCH HIGHLIGHTS
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Prostate cancer: ADT-who, when and for how long?
p403 | doi:10.1038/nrurol.2009.131
http://links.ealert.nature.com/ctt?kn=49&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Prostate cancer: MRI accurately predicts pathological stage
p404 | doi:10.1038/nrurol.2009.133
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Prostate cancer: The benefits of preoperative stress-management training
p404 | doi:10.1038/nrurol.2009.134
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Male factor infertility: Stress compromises sperm quality
p405 | doi:10.1038/nrurol.2009.135
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Sexual dysfunction: Glutamatergic system mediates sexual side effects of SSRIs
p405 | doi:10.1038/nrurol.2009.136
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Bag sampling of urine too unreliable
p405 | doi:10.1038/nrurol.2009.137
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Radiotherapy: Five-year PSA value predicts survival
p406 | doi:10.1038/nrclinonc.2009.99
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Subfertility and testicular cancer
p406 | doi:10.1038/nrurol.2009.138
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Pain: UPOINT for interstitial cystitis
p407 | doi:10.1038/nrurol.2009.139
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IN BRIEF
Testicular cancer | Testicular cancer | Bladder cancer | Prostate cancer
p407 | doi:10.1038/nrurol.2009.142
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Kidney cancer: Use sorafenib first in sequential TKI regimens
p408 | doi:10.1038/nrurol.2009.140
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Urinary incontinence: Relative efficacy of sling procedures: question
answered
p408 | doi:10.1038/nrurol.2009.141
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NEWS AND VIEWS
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Reproductive endocrinology: Hormonal male contraception-a goal finally
realized?
Robert E. Brannigan
p409 | doi:10.1038/nrurol.2009.129
Surveys show that both men and their female partners are interested in
a 'male pill'. A near-unanimous majority of women in stable relationships
would trust their partner to assume responsibility for contraception. The
results of a Chinese multicenter, phase III trial of monthly testosterone
injections bring us a step closer to making this great leap forward.
http://links.ealert.nature.com/ctt?kn=63&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Prostate cancer: pT3N0M0 prostate cancer: a plea for adjuvant radiation
Michel Bolla and Laurence Collette
p410 | doi:10.1038/nrurol.2009.103
Patients with pT3N0M0 disease after radical prostatectomy for localized
prostate cancer are at risk for local relapse. Immediate radiation therapy
is known to improve local control and biochemical disease-free survival
in these individuals. What effect, then, does it have on metastasis and
overall survival?
http://links.ealert.nature.com/ctt?kn=32&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Prostate cancer: Intermittent androgen deprivation-questions remain
Daniel Keizman and Michael A. Carducci
p412 | doi:10.1038/nrurol.2009.145
The South European Uroncological Group has conducted a phase III trial
comparing intermittent androgen deprivation with continuous therapy in
patients with advanced prostate cancer. The intermittent regimen was found
to be non-inferior in terms of disease progression, survival, and quality
of life. Nevertheless, the implications of such research for patient
management remain controversial.
http://links.ealert.nature.com/ctt?kn=77&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
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REVIEWS
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Erectile dysfunction following prostatectomy: prevention and treatment
Ahmed Magheli and Arthur L. Burnett
p415 | doi:10.1038/nrurol.2009.126
Erectile dysfunction following radical prostatectomy is common in men
recovering from prostate cancer. The authors of this Review discuss the
measures that can be taken to help preserve erectile function in men
undergoing this surgery and approaches to treating men with postprostatectomy
erectile dysfunction, including the concept of penile rehabilitation.
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
ETS gene fusions in prostate cancer
Jeremy P. Clark and Colin S. Cooper
p429 | doi:10.1038/nrurol.2009.127
The discovery of recurrent ETS gene fusions in prostate cancer has improved
our understanding of prostate carcinogenesis and suggests novel targets
for therapy. Here, Clark and Cooper discuss the variety of ETS gene fusions
and their role in prostate cancer development, and outline the prognostic
and therapeutic implications of this knowledge.
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Ureteral stent symptoms and associated infections: a biomaterials perspective
Ben H. Chew and Dirk Lange
Published online: 14 July 2009
p440 | doi:10.1038/nrurol.2009.124
Stent-related symptoms are the cause of considerable morbidity for patients
who undergo urological procedures. Here, Chew and Lange describe how
urologists can limit the complications of stent placement, focusing on
the ongoing development of stent technology to prevent bacterial adhesion
and infection.
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
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CASE STUDY
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An antenatally diagnosed rhabdomyosarcoma of the bladder treated without
extensive surgery
Shadi Abdar Esfahani, Laleh Montaser-Kouhsari, Parisa Saeedi, Zhina Sadeghi
and Abdol-Mohammad Kajbafzadeh
p449 | doi:10.1038/nrurol.2009.99
This Case Study discusses the management of a female neonate in whom a
large pelvic mass had been detected 9 weeks before birth. She was diagnosed
with botryoid rhabdomyosarcoma of the bladder. Tumor eradication was
achieved with chemotherapy alone, and she remained free from recurrence
during 24 months of follow-up.
Abstract: http://links.ealert.nature.com/ctt?kn=51&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Alternative splicing and biological heterogeneity in prostate cancer
Prabhakar Rajan, David J. Elliott, Craig N. Robson and Hing Y. Leung
p454 | doi:10.1038/nrurol.2009.125
Alternative splicing has been proposed as a key contributor to the genetic
diversity observed in prostate tumors. Here, the authors focus on the
clinically relevant consequences of alternative splicing in prostate cancer,
and describe how cancer-specific splicing events may be exploited as novel
biomarkers and therapeutic targets for individualized care of patients.
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=33819909&r=MTc2NDg0NjM5NAS2&b=2&j=NTUyMjQwMTAS1&mt=1&rt=0
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