20 August 2009 Volume 460 Number 7258, pp 933 - 1050
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An Indian hotspot
Analysis of satellite data and land-surface models reveals that
groundwater in northwestern India is being depleted at an
unsustainable rate. In the latest Nature Video, the researchers
discuss their findings, and what this means for India's water supply.
Watch the Nature Video free online.
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For more on this topic listen to this week's Nature Podcast.
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EDITORIALS
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Common consent p933
The distribution of human cell lines used in research should not be
hindered by restrictions from donors.
doi:10.1038/460933a
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A question of control p933
Scientists must address the ethics of using neuroactive compounds
to quash domestic crises.
doi:10.1038/460933b
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RESEARCH HIGHLIGHTS
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Biomaterials: Pearly pedigree p934
doi:10.1038/460934a
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Animal behaviour: Ties that bind p934
doi:10.1038/460934b
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Physics: Close heat p934
doi:10.1038/460934c
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Bioelectronics: It's electrifying p934
doi:10.1038/460934d
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Population ecology: Evolution to the rescue p934
doi:10.1038/460934e
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Neuroscience: Categorically hard-wired pp934-935
doi:10.1038/460934f
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Cancer: From the source p935
doi:10.1038/460935a
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Biophysics: Protein friction p935
doi:10.1038/460935b
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Immunology: Helping the helpers p935
doi:10.1038/460935c
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Planetary science: What an atmosphere p935
doi:10.1038/460935d
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JOURNAL CLUB
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Journal club p935
Heather Stoll
doi:10.1038/460935e
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NEWS
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Paying to save the rainforests pp936-937
In Brazil, details are emerging for plans to stop deforestation.
Can it serve as a model for other nations?
Jeff Tollefson
doi:10.1038/460936a
http://links.ealert.nature.com/ctt?kn=157&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Nanoparticle safety in doubt p937
Lung damage in Chinese factory workers sparks health fears.
Natasha Gilbert
doi:10.1038/460937a
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Japan election sparks science pledges p938
Both parties make vague promises about research, but differ in
their climate targets.
David Cyranoski
doi:10.1038/460938a
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Collins sets out his vision for the NIH p939
Translational research and neglected diseases are on the agenda for
incoming director.
Elie Dolgin
doi:10.1038/460939a
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Environmental concerns delay seismic testing p939
Lawsuit puts research voyage on hold.
Rex Dalton
doi:10.1038/460939b
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Cardiovascular disease gets personal pp940-941
Gene-association studies hint at better ways of treating the leading
cause of death, but capitalizing on them is proving to be a slow and
difficult process. Erika Check Hayden reports.
Erika Check Hayden
doi:10.1038/460940a
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NASA needs more money to track asteroid threats p943
doi:10.1038/460943a
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World population will grow fastest in poorest areas p943
doi:10.1038/460943b
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Australia seeks carbon-reduction compromise p943
doi:10.1038/460943c
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Innovation urged for water management in Asia p943
doi:10.1038/460943d
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Conflict of interest and resignation at drug agency p943
doi:10.1038/460943e
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Climate gloom p943
doi:10.1038/460943f
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NEWS FEATURES
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Biodiversity: Rack and field pp944-946
Ecologists have struggled to reconcile what they see in the lab and
in the wild. But both views are needed to understand the effects
of extinction, finds Virginia Gewin.
Virginia Gewin
doi:10.1038/460944a
http://links.ealert.nature.com/ctt?kn=19&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Mouse genetics: The check-up pp947-948
Patients checking in to the German Mouse Clinic will undergo the most
sophisticated medical testing in the world. But, finds Alison Abbott,
the waiting list is becoming a problem.
Alison Abbott
doi:10.1038/460947a
http://links.ealert.nature.com/ctt?kn=22&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
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CORRESPONDENCE
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OPINION
International peer review improved Irish research rankings p949
Conor O'Carroll
doi:10.1038/460949a
http://links.ealert.nature.com/ctt?kn=55&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Hispanic people start leaping over barriers to better jobs p949
Annelyn Torres-Reveron
doi:10.1038/460949b
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Whistleblowers at risk as science fails to correct itself p949
Eugenie Samuel Reich
doi:10.1038/460949c
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South Dakota school replies to sexual harassment claims p949
Deborah L. Sloat
doi:10.1038/460949d
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OPINION
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Biologists napping while work militarized pp950-951
As researchers discover more agents that alter mental states, the
Chemical Weapons Convention needs modification to help ensure that
the life sciences are not used for hostile purposes,
says Malcolm Dando.
doi:10.1038/460950a
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Misadventures in the Burgess Shale pp952-953
One hundred years after Charles Doolittle Walcott found a wealth of
Cambrian fossils in the Rocky Mountains of British Columbia,
Desmond Collins reflects on the bumpy road of their classification.
doi:10.1038/460952a
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BOOKS AND ARTS
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OPINION
Leading the fight against smallpox pp954-955
Donald Henderson directed the World Health Organization's effort to
eradicate the variola virus. His memoir is a lesson in managing
complex projects and personalities, says John Carmody.
John Carmody reviews Smallpox: The Death of a Disease
by D. A. Henderson
doi:10.1038/460954a
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Space for improvement at NASA p955
Scott Pace reviews Organizational Learning at NASA: The Challenger
and Columbia Accidents by Julianne G. Mahler and
Maureen Hogan Casamayou
doi:10.1038/460955a
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No more fish in the sea p956
Olive Heffernan reviews The End of the Line by Charles Clover and
Rupert Murray
doi:10.1038/460956a
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An eye for evidence pp956-957
Laura Spinney reviews The Scene of the Crime: Rodolphe A. Reiss
(1875–1929)
doi:10.1038/460956b
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Earliest sketches of the Moon p957
John Whitfield reviews Cosmos and Culture: How Astronomy Has Shaped
Our World
doi:10.1038/460957a
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Correction p957
doi:10.1038/460957b
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NEWS AND VIEWS
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Plant biology: Genetics of high-rise rice pp959-960
When subject to flooding, deepwater rice survives by shooting up in
height. Knowledge of the genetic context of this and other responses
to inundation will be a boon in enhancing rice productivity.
Laurentius A. C. J. Voesenek and Julia Bailey-Serres
doi:10.1038/460959a
http://links.ealert.nature.com/ctt?kn=3&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Chemical physics: Electronic movies pp960-961
Strong laser fields can tear an electron away from a molecule,
leaving a hole in the electronic wavefunction that races
through the molecule. The ultrafast motion of such a hole has
been traced at last.
Marc Vrakking
doi:10.1038/460960a
http://links.ealert.nature.com/ctt?kn=6&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Neuroscience: Activity acts locally pp961-963
How does neuronal activity affect the development of neural circuits?
Work on the retina shows that blocking activity at the synapses
between neurons reduces local synapse assembly without affecting
global cellular structure.
Jonathan B. Demb and Marla B. Feller
doi:10.1038/460961a
http://links.ealert.nature.com/ctt?kn=34&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Planetary science: Archaeology of the asteroid belt pp963-964
The size of asteroids in the Solar System's main asteroid belt may
help constrain one of the least-understood aspects of planet
formation -- the transition from pebble-sized dust balls to
mountain-sized planetesimals.
John Chambers
doi:10.1038/460963a
http://links.ealert.nature.com/ctt?kn=33&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Astrophysics: Gravity ripples chased pp964-965
Discovering gravitational waves would not only validate Einstein's
theory of gravitation but also reveal aspects of the Universe's
earliest moments. The hunt for these elusive ripples is now well
under way.
Marc Kamionkowski
doi:10.1038/460964a
http://links.ealert.nature.com/ctt?kn=27&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
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HYPOTHESIS
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Evidence for an early prokaryotic endosymbiosis pp967-971
James A. Lake
doi:10.1038/nature08183
Abstract: http://links.ealert.nature.com/ctt?kn=284&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=293&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
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ARTICLES
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High harmonic interferometry of multi-electron dynamics in molecules
pp972-977
The high harmonic emission that accompanies the recombination of an
electron with its parent molecular ion in an intense laser field
provides a snapshot of the structure and dynamics of the recombining
system. Experiments on CO2 molecules now show how to extract
information from the properties of the emitted light about the
underlying multi-electron dynamics with sub-Angstrom spatial
resolution and attosecond temporal resolution
Olga Smirnova et al.
doi:10.1038/nature08253
Abstract: http://links.ealert.nature.com/ctt?kn=286&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=299&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Homotypic fusion of ER membranes requires the dynamin-like GTPase
Atlastin pp978-983
The mechanism by which the tubular architecture of the endoplasmic
reticulum (ER) is maintained is unclear, although homotypic membrane
fusion is known to be required for ER biogenesis and maintenance and
this is dependent on GTP hydrolysis. Here it is demonstrated that
loss of the GTPase Atlastin in Drosophila causes ER fragmentation,
whereas its overexpression induces enlargement of ER profiles.
Genny Orso et al.
doi:10.1038/nature08280
Abstract: http://links.ealert.nature.com/ctt?kn=287&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=308&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Specific pathways prevent duplication-mediated genome rearrangements
pp984-989
The human genome contains numerous types of repeated 'at risk'
sequences that can cause genomic rearrangements and instability.
Various proteins are used to ensure that this occurs very infrequently.
Here, a comprehensive analysis of the factors involved in suppressing
gross chromosomal rearrangements in Saccharomyces cerevisiae shows that
there are distinct pathways for suppressing rearrangements mediated
by single copy sequences versus repetitive 'at risk' sequences.
Christopher D. Putnam, Tikvah K. Hayes and Richard D. Kolodner
doi:10.1038/nature08217
Abstract: http://links.ealert.nature.com/ctt?kn=295&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
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Latest Research Highlights
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LETTERS
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An upper limit on the stochastic gravitational-wave background of
cosmological origin pp990-994
A stochastic background of gravitational waves is expected to arise
from a superposition of a large number of unresolved gravitational-wave
sources and should carry unique signatures from the earliest epochs
of the Universe. Limits on the amplitude of the stochastic
gravitational-wave background are now reported using the data from a
two-year science run of the Laser Interferometer Gravitational-wave
Observatory. These limits rule out certain models of early Universe
evolution.
The LIGO Scientific Collaboration & The Virgo Collaboration
doi:10.1038/nature08278
Abstract: http://links.ealert.nature.com/ctt?kn=290&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=281&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
In situ observation of incompressible Mott-insulating domains in
ultracold atomic gases pp995-998
Ultracold atoms held in an optical lattice are an important system
in which to study quantum phase transitions. However, the presence
of multiple quantum phases within a single sample complicates the
interpretation of bulk measurements. Here, a direct imaging method
is reported that enables a complete characterization of multiple
phases in a strongly correlated Bose gas.
Nathan Gemelke, Xibo Zhang, Chen-Lung Hung and Cheng Chin
doi:10.1038/nature08244
Abstract: http://links.ealert.nature.com/ctt?kn=292&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=283&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Satellite-based estimates of groundwater depletion in India pp999-1002
Indirect evidence suggests that groundwater is being consumed faster
than it is naturally being replenished in northwest India, but there
has been no regional assessment of the rate of groundwater depletion.
Terrestrial water storage-change observations and simulated
soil-water variations from a modelling system are now used to show
that groundwater is indeed being depleted and that its use for
irrigation and other anthropogenic uses is likely to be the cause.
Matthew Rodell, Isabella Velicogna and James S. Famiglietti
doi:10.1038/nature08238
Abstract: http://links.ealert.nature.com/ctt?kn=300&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=256&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Global electromagnetic induction constraints on transition-zone water
content variations pp1003-1006
Electrical conductivity is highly sensitive to the presence of
hydrogen in mantle materials, an important measure as small amounts
of water can significantly affect the physical properties of mantle
materials, with profound implications for the dynamic and
geochemical evolution of the Earth. Here, long-period geomagnetic
response functions are used to derive a global-scale three-dimensional
model of electrical conductivity variations in the Earth's mantle.
Anna Kelbert, Adam Schultz and Gary Egbert
doi:10.1038/nature08257
Abstract: http://links.ealert.nature.com/ctt?kn=302&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=251&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Phase-locking and environmental fluctuations generate synchrony in a
predator–prey community pp1007-1010
Adjacent populations that are involved in similar predator-prey
cycles often oscillate in synchrony. Here, a general stochastic
model of predator-prey spatial dynamics is developed to predict
the outcome of a laboratory microcosm experiment testing for
interactions among synchronizing factors; both model and data
indicate that synchrony depends on cyclic dynamics generated by
the predator.
David A. Vasseur and Jeremy W. Fox
doi:10.1038/nature08208
Abstract: http://links.ealert.nature.com/ctt?kn=296&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=121&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
A highly annotated whole-genome sequence of a Korean individual
pp1011-1015
Human genome sequences have so far been reported for individuals with
ancestry in three distinct geographical regions: a Yoruba African,
two individuals of northwest European origin, and a person from China.
Here, using a combination of methods, a highly annotated, whole-genome
sequence is provided for a Korean male.
Jong-Il Kim et al.
doi:10.1038/nature08211
Abstract: http://links.ealert.nature.com/ctt?kn=298&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=133&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Neurotransmission selectively regulates synapse formation in parallel
circuits in vivo pp1016-1020
Activity is thought to help shape connectivity within neural circuits,
with differences often leading to the elimination of less active
connections. In order to imbalance neurotransmission from different
sets of inputs in vivo, a subpopulation of bipolar cells was
inactivated during development. The results reveal an unexpected and
remarkably selective role for activity in circuit development,
regulating synapse formation but not elimination.
Daniel Kerschensteiner et al.
doi:10.1038/nature08236
Abstract: http://links.ealert.nature.com/ctt?kn=307&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
In vitro and in vivo characterization of new swine-origin H1N1
influenza viruses pp1021-1025
On 11 June 2009 the World Health Organization declared that the
infections caused by a new strain of influenza A virus closely
related to swine viruses had reached pandemic levels. Here, one
of the first US isolates of the new swine-origin H1N1 influenza
virus (S-OIV) is characterized, as well as several other S-OIV
isolates, both in vitro and in vivo.
Yasushi Itoh et al.
doi:10.1038/nature08260
Abstract: http://links.ealert.nature.com/ctt?kn=309&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
The ethylene response factors SNORKEL1 and SNORKEL2 allow rice to
adapt to deep water pp1026-1030
In Asia, flooding during the monsoon season can result in widespread
devastation of rice crops. Deepwater rice has evolved and adapted to
flooding by acquiring the ability to significantly elongate its
internodes. The molecular mechanism of this deepwater response is now
identified as being dependent on the genes SNORKEL1 and SNORKEL2,
which trigger deepwater response by encoding ethylene response factors
involved in ethylene signalling.
Yoko Hattori et al.
doi:10.1038/nature08258
Abstract: http://links.ealert.nature.com/ctt?kn=304&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Characterization of two classes of small molecule inhibitors of
Arp2/3 complex pp1031-1034
The actin cytoskeleton plays a critical role in cell biological
processes such as cell adhesion, migration and endocytosis.
Polymerization of actin filaments directed by the actin-related
protein (Arp)2/3 complex supports many types of cellular movement.
Two classes of small molecules that bind to different sites on the
Arp2/3 complex and inhibit its ability to nucleate actin filaments
are now described; these inhibitors provide a powerful approach for
studying the Arp2/3 complex in living cells.
B. J. Nolen et al.
doi:10.1038/nature08231
Abstract: http://links.ealert.nature.com/ctt?kn=241&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
XIAP discriminates between type I and type II FAS-induced apoptosis
pp1035-1039
The 'death receptor' FAS regulates apoptosis of unwanted or dangerous
cells, functioning as a guardian against autoimmunity and cancer
development. Distinct cell types differ in the mechanisms by which
FAS triggers apoptosis: in type I cells, FAS-induced activation of
caspase-8 suffices for cell killing, whereas in type II cells there
must be caspase cascade amplification. Here it is shown that the
inhibitor of apoptosis XIAP is the critical factor determining
this -- without it, a type II cell dies in the same way as a
type I cell.
Philipp J. Jost et al.
doi:10.1038/nature08229
Abstract: http://links.ealert.nature.com/ctt?kn=242&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=200&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Structure of a prokaryotic virtual proton pump at 3.2 A resolution
pp1040-1043
Little is known about the structure of the APC superfamily of membrane
proteins, which transport amino acids, polyamines and organic cations
in a multitude of biological roles. Here, the crystal structure of a
member of this family, AdiC, is described at 3.2 A resolution.
Yiling Fang et al.
doi:10.1038/nature08201
Abstract: http://links.ealert.nature.com/ctt?kn=243&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=204&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
----------------------
ERRATUM
----------------------
Kinematic variables and water transport control the formation and
location of arc volcanoes p1044
T. L. Grove et al.
doi:10.1038/nature08312
http://links.ealert.nature.com/ctt?kn=205&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
----------------------
CORRIGENDA
----------------------
Generation of pluripotent stem cells from adult human testis p1044
Sabine Conrad et al.
doi:10.1038/nature08353
http://links.ealert.nature.com/ctt?kn=233&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Dual nature of the adaptive immune system in lampreys p1044
Peng Guo et al.
doi:10.1038/nature08354
http://links.ealert.nature.com/ctt?kn=226&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Careers Q&A
Lucia Votano p1047
Incoming director of the National Laboratory in Gran Sasso, Italy.
Karen Kaplan
doi:10.1038/nj7258-1047a
http://links.ealert.nature.com/ctt?kn=145&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Postdoc journal
Failure to communicate p1047
It pays to be clear and concise.
Bryan Venters
doi:10.1038/nj7258-1047b
http://links.ealert.nature.com/ctt?kn=160&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
In Brief
UK lab to get new digs p1047
Government backs plan to rebuild 'shabby' research centre.
doi:10.1038/nj7258-1047c
http://links.ealert.nature.com/ctt?kn=158&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
In Brief
Banking on energy p1047
US national labs and battery makers stand to benefit from cash
injection into green cars.
doi:10.1038/nj7258-1047d
http://links.ealert.nature.com/ctt?kn=169&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
----------------------
FUTURES
----------------------
The Piltdown angel p1050
Dig for victory.
John P. Boyd
doi:10.1038/4601050a
http://links.ealert.nature.com/ctt?kn=224&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
19 August 2009
A genetically encoded photoactivatable Rac controls the motility of
living cells
Yi I. Wu et al.
doi:10.1038/nature08241
Abstract: http://links.ealert.nature.com/ctt?kn=229&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=229&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Coordination of Rho GTPase activities during cell protrusion
Matthias Machacek et al.
doi:10.1038/nature08242
Abstract: http://links.ealert.nature.com/ctt?kn=179&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=179&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Direct observation of the binding state of the kinesin head to
the microtubule
Nicholas R. Guydosh and Steven M. Block
doi:10.1038/nature08259
Abstract: http://links.ealert.nature.com/ctt?kn=176&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=176&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Antioxidant and oncogene rescue of metabolic defects caused by loss
of matrix attachment
Zachary T. Schafer et al.
doi:10.1038/nature08268
Abstract: http://links.ealert.nature.com/ctt?kn=177&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=177&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Changes of mind in decision-making
Arbora Resulaj, Roozbeh Kiani, Daniel M. Wolpert and Michael N. Shadlen
doi:10.1038/nature08275
Abstract: http://links.ealert.nature.com/ctt?kn=195&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=195&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Modelling pathogenesis and treatment of familial dysautonomia using
patient-specific iPSCs
Gabsang Lee et al.
doi:10.1038/nature08320
Abstract: http://links.ealert.nature.com/ctt?kn=192&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=192&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Histone H2A.Z cooperates with RNAi and heterochromatin factors to
suppress antisense RNAs
Martin Zofall et al.
doi:10.1038/nature08321
Abstract: http://links.ealert.nature.com/ctt?kn=188&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=188&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
16 August 2009
Targeted capture and massively parallel sequencing of 12 human exomes
Sarah B. Ng et al.
doi:10.1038/nature08250
Abstract: http://links.ealert.nature.com/ctt?kn=185&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=185&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Genetic variation in IL28B predicts hepatitis C treatment-induced
viral clearance
Dongliang Ge et al.
doi:10.1038/nature08309
Abstract: http://links.ealert.nature.com/ctt?kn=274&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=274&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Demonstration of a spaser-based nanolaser
M. A. Noginov et al.
doi:10.1038/nature08318
Abstract: http://links.ealert.nature.com/ctt?kn=280&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=280&m=33893258&r=MjA1NTkxMDA2MAS2&b=2&j=NTY4ODk4NTAS1&mt=1&rt=0
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