Signaling Gateway - 17 July 2009
http://links.ealert.nature.com/ctt?kn=36&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=29&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
SPHINGOSINE 1-PHOSPHATE SIGNALING: TREG OR NOT TREG, THAT IS
THE QUESTION
S1P1 activates the mTOR–Akt pathway to suppress Treg-cell
differentiation and activity.
Original research paper: Nature Immunology 10, 769-777 2009
http://links.ealert.nature.com/ctt?kn=14&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
------------------------
Molecule Pages
------------------------
FOXL2
http://links.ealert.nature.com/ctt?kn=23&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
Forkhead box L2 (Foxl2) is a forkhead transcription factor. In goats
and mice, inactivation of Foxl2 is associated with craniofacial
anomalies and ovarian dysfunction, including various degrees of
ovary-to-testis sex reversal. In vitro experiments have suggested
that FOXL2 is involved in the regulation of cholesterol and steroid
metabolism, apoptosis, reactive oxygen species detoxification and
inflammation processes. Further in vivo experiments are required to
validate these target pathways.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=4&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
-------------------
Selected Updates
-------------------
CELL SIGNALLING: A FERTILITY NETWORK
In ovarian granulosa cells, luteinizing hormone (LH)-induced
signaling activates ERK1 and ERK2 to trigger reprogramming and
terminal differentiation.
Original research paper: Science 324, 938-941 (2009)
http://links.ealert.nature.com/ctt?kn=30&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
SIGNALLING: HEDGEHOG DOESN'T...
Hedgehog signaling is not required for adult hematopoietic
homeostasis or for the development of some leukemias, suggesting that
although systemic administration of hedgehog antagonists is unlikely
to cause significant hematological toxicity, it is also not a
promising therapy for these leukemias.
Original research paper: Cell Stem Cell 4, 548-558 (2009)
http://links.ealert.nature.com/ctt?kn=37&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
SPINE FORMATION: SIGNALLING GROWTH
Gamma-secretase, a protein linked to linked to early-onset
Alzheimer's disease, cleaves ephrin receptor A4 (EPHA4) following
synaptic activation and triggers the formation of dendritic spines.
Original research paper: J. Cell. Biol. 185, 551-564 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=32&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
------------------------
Research Library
------------------------
http://links.ealert.nature.com/ctt?kn=17&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
RAPAMYCIN FED LATE IN LIFE EXTENDS LIFESPAN IN GENETICALLY
HETEROGENEOUS MICE
Nature 460, 392-395 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
ESSENTIAL ROLE FOR EIF4GI OVEREXPRESSION IN THE PATHOGENESIS OF
INFLAMMATORY BREAST CANCER
Nature Cell Biology 11, 903-908 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
MACROPHAGE COLONY-STIMULATING FACTOR INDUCES THE PROLIFERATION AND
SURVIVAL OF MACROPHAGES VIA A PATHWAY INVOLVING DAP12 AND
BETA-CATENIN
Nature Immunology 10, 734-743 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
------------------------
Signaling News
------------------------
SYSTEMS BIOLOGY: UNTANGLING THE PROTEIN WEB
http://links.ealert.nature.com/ctt?kn=12&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
Researchers have identified thousands of macromolecular interactions
within cells, but linking these interactions to create networks still
poses a big challenge. This Nature technology feature examines why
results from similar large-scale protein-protein interaction studies
may not always agree, and explores methods to build comprehensive and
reliable interaction maps from these data.
More news
http://links.ealert.nature.com/ctt?kn=28&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
-------------------------
Gateway Updates
-------------------------
NCI-NATURE PATHWAY INTERACTION DATABASE - JULY UPDATE
http://links.ealert.nature.com/ctt?kn=13&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
This month's update features the E2F transcription factor network,
ErbB2/ErbB3 signaling events and an introduction to the Human
Protein Atlas.
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://links.ealert.nature.com/ctt?kn=21&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
-----------------------------
Job of the Week
-----------------------------
Systems Biologist
Employer: Systems Biologist
Location: Vancouver, Canada
http://links.ealert.nature.com/ctt?kn=11&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
A two-year position is available for a Postdoctoral Research Fellow
in systems biology, biostatistics and bioinformatics. The objectives
of the study are to understand biological signaling networks and to
develop practical applications through modeling and analysis.
The successful applicant will participate in genomics projects,
conduct data mining and analysis, and develop methods in
computational and systems/network biology.
More Jobs:
http://links.ealert.nature.com/ctt?kn=2&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=25&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://links.ealert.nature.com/ctt?kn=7&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://links.ealert.nature.com/ctt?kn=35&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
For further technical assistance or any other enquiries, please click here:
http://links.ealert.nature.com/ctt?kn=1&m=33635316&r=MTc2ODc4NDI0MAS2&b=2&j=NTMzODg2NTYS1&mt=1&rt=0
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2009 Nature Publishing Group
---------------------------------------------------------------------
