16 July 2009 Volume 460 Number 7253, pp 307 - 428
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*Nature News Special: Apollo 40 years on
On 20 July 1969, NASA's Apollo programme landed a man on the Moon,
less than a decade after President John F Kennedy announced the goal
to Congress. On the 40th anniversary of that milestone, Nature looks
at the legacy of the Apollo missions and their influence on lunar
science, as well as prospects for future manned missions that could
see humans once again set foot on the Moon.
Access selected content from the special free online.
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Follow the journey on our ApolloPlus40 twitter.
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EDITORIALS
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Net gains p307
The Moon landing was not the only world-changing event in the summer
of '69.
doi:10.1038/460307a
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Nowhere to hide p307
The G8 has laid down a marker by promising to restrict the rise of
global temperatures.
doi:10.1038/460307b
http://links.ealert.nature.com/ctt?kn=225&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Animal behaviour: Smothered by a swarm p308
doi:10.1038/460308a
http://links.ealert.nature.com/ctt?kn=6&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Palaeoclimatology: Tropical ice p308
doi:10.1038/460308b
http://links.ealert.nature.com/ctt?kn=345&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Nanotechnology: Penned in protein p308
doi:10.1038/460308c
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Chemical biology: A glowing report p308
doi:10.1038/460308d
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Evolution: Nice guys finish last p308
doi:10.1038/460308e
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Organic chemistry: Cockroach cruncher p309
doi:10.1038/460309a
http://links.ealert.nature.com/ctt?kn=264&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Immunology: Themis in the thymus p309
doi:10.1038/460309b
http://links.ealert.nature.com/ctt?kn=242&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Developmental biology: The turtle fold p309
doi:10.1038/460309c
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Neurology: New neurons show the way p309
doi:10.1038/460309d
http://links.ealert.nature.com/ctt?kn=347&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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JOURNAL CLUB
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Journal club p309
Friedhelm von Blanckenburg
doi:10.1038/460309e
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NEWS
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NIH nominee draws scrutiny pp310-311
Francis Collins is likely to face funding challenges — and criticism
of his Christian evangelism.
Meredith Wadman
doi:10.1038/460310a
http://links.ealert.nature.com/ctt?kn=206&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Malaria drug-makers ignore WHO ban pp310-311
Health agency calls for clampdown on artemisinin monotherapy.
Declan Butler
doi:10.1038/460310b
http://links.ealert.nature.com/ctt?kn=103&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Flu furore hits Argentina p311
Refusal to declare national emergency restricts pandemic measures.
Anna Petherick
doi:10.1038/460311a
http://links.ealert.nature.com/ctt?kn=101&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Medical isotope shortage reaches crisis level pp312-313
Robust solutions sought urgently to shore up fragile supply chain.
Paula Gould
doi:10.1038/460312a
http://links.ealert.nature.com/ctt?kn=65&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
G8 climate target questioned p313
Is a commitment to prevent global temperatures from rising more than
2°C enough?
Quirin Schiermeier
doi:10.1038/460313a
http://links.ealert.nature.com/ctt?kn=57&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Shooting for the Moon pp314-315
The Apollo programme inspired thousands of people to pursue careers in
science. Today, they still support human spacefaring — but baulk at the
price. Richard Monastersky reports on the results of a Nature poll.
Richard Monastersky
doi:10.1038/460314a
http://links.ealert.nature.com/ctt?kn=314&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Arms pact could boost US-Russian science p316
Commitment to cut nuclear stockpiles may improve collaboration.
Geoff Brumfiel
doi:10.1038/460316a
http://links.ealert.nature.com/ctt?kn=320&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Europe attacks tactics that delay generic drugs p317
doi:10.1038/460317a
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Obama names next head of US Geological Survey p317
doi:10.1038/460317b
http://links.ealert.nature.com/ctt?kn=42&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
El Niño arrives in the Pacific Ocean p317
doi:10.1038/460317c
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German molecular biologist to head EMBO p317
doi:10.1038/460317d
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US renewable energy gets cash boost p317
doi:10.1038/460317e
http://links.ealert.nature.com/ctt?kn=93&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Mars Science Laboratory devours budgets p317
doi:10.1038/460317f
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Correction p317
doi:10.1038/460317g
http://links.ealert.nature.com/ctt?kn=62&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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NEWS FEATURES
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Cell biology: Ahead of the curve pp318-320
Cellular life is all slopes, arcs and circles — but there is much
debate about how these curves are built. Kendall Powell reports.
Kendall Powell
doi:10.1038/460318a
http://links.ealert.nature.com/ctt?kn=344&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Earth science: A lakeful of trouble pp321-323
Africa's Lake Kivu contains vast quantities of gas, which makes it
both dangerous and valuable. Anjali Nayar asks whether it is
possible to tap the gas without causing a disaster.
Anjali Nayar
doi:10.1038/460321a
http://links.ealert.nature.com/ctt?kn=336&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
Sharing different mouse strains is not always so simple p324
Richard Behringer
doi:10.1038/460324a
http://links.ealert.nature.com/ctt?kn=361&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Invasion biology is a discipline that's too young to die p324
Petr Pysek and Philip E. Hulme
doi:10.1038/460324b
http://links.ealert.nature.com/ctt?kn=114&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
For cancer, seek and destroy or live and let live? p324
Nicolas Andre and Eddy Pasquier
doi:10.1038/460324c
http://links.ealert.nature.com/ctt?kn=120&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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ESSAY
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Why we need space travel p325
Giovanni Bignami reflects on the people who persuaded him that we
must send humans beyond Earth's orbit to inspire public and
political support for science.
Giovanni Bignami
doi:10.1038/460325a
http://links.ealert.nature.com/ctt?kn=100&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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BOOKS AND ARTS
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The slow slide towards a new battlefield? pp326-327
The cold war saw governments develop international policies to regulate
outer space for military and civil uses. Loopholes in those policies
must now be closed, writes Roald Sagdeev.
Roald Sagdeev reviews The Politics of Space Security: Strategic
Restraint and the Pursuit of National Interests by James Clay Moltz
doi:10.1038/460326a
http://links.ealert.nature.com/ctt?kn=71&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
The return path to the Moon pp327-328
Jeff Kanipe reviews The Seventh Landing: Going Back to the Moon, This
Time to Stay by Michael Carroll
doi:10.1038/460327a
http://links.ealert.nature.com/ctt?kn=351&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Apollo books p328
doi:10.1038/460328a
http://links.ealert.nature.com/ctt?kn=69&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
In Retrospect: Calvino's Cosmicomics p329
The soaring imagination of the Italian author abounds in a new
compilation of his cosmic fables. Mostly written in the age of the
space race, they are heavily informed by science, finds Alan Lightman.
Alan Lightman reviews The Complete Cosmicomics by Italo Calvino,
William Weaver, Tim Parks and Martin McLaughlin
doi:10.1038/460329a
http://links.ealert.nature.com/ctt?kn=55&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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NEWS AND VIEWS
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Ageing: A midlife longevity drug? pp331-332
The small molecule rapamycin, already approved for clinical use for
various human disorders, has been found to significantly increase
lifespan in mice. Is this a step towards an anti-ageing drug for
people?
Matt Kaeberlein and Brian K. Kennedy
doi:10.1038/460331a
http://links.ealert.nature.com/ctt?kn=75&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Atmospheric physics: Cosmic rays, clouds and climate pp332-333
Galactic cosmic rays could influence Earth's cloudiness by creating
aerosol particles that prompt cloud formation. That possible effect
looks to be smaller than thought, but the story won't end there.
Ken Carslaw
doi:10.1038/460332a
http://links.ealert.nature.com/ctt?kn=59&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Galaxy formation: Anatomy of elliptical galaxies pp333-334
The family of elliptical galaxies is remarkable for the structural
regularity of its members. Inspecting irregularities in this
regularity could help in understanding how these galaxies form.
Luca Ciotti
doi:10.1038/460333a
http://links.ealert.nature.com/ctt?kn=44&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Ecology: Towards a theory of biodiversity pp334-335
Models of ecological communities that incorporate mutation and
spatial dispersal can yield results that go some way to explaining
observations. A further step is to add sexual reproduction to the mix.
Jayanth R. Banavar and Amos Maritan
doi:10.1038/460334a
http://links.ealert.nature.com/ctt?kn=51&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Climate change: Beyond the CO2 connection pp335-336
At times in the past, mobile ocean fronts in the subtropics have
exercised an influence on the magnitude of climate change by
decoupling temperature from levels of carbon dioxide in the
atmosphere.
Rainer Zahn
doi:10.1038/460335a
http://links.ealert.nature.com/ctt?kn=190&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Photonics: Light control at will p337
Microchips that make use of light instead of electrons could outperform
their electronic counterparts if light flow can be controlled at will.
Photonic crystals are instrumental in achieving such a manoeuvre.
Sajeev John
doi:10.1038/460337a
http://links.ealert.nature.com/ctt?kn=346&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Obituary: Jean Dausset (1916-2009) p338
'Father' of the human leukocyte antigen system.
Dominique J. Charron
doi:10.1038/460338a
http://links.ealert.nature.com/ctt?kn=218&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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REVIEW
----------------------
Primate archaeology pp339-344
Michael Haslam et al.
doi:10.1038/nature08188
Abstract: http://links.ealert.nature.com/ctt?kn=223&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=229&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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ARTICLES
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The Schistosoma japonicum genome reveals features of host-parasite
interplay pp345-351
Schistosoma mansoni and Schistosoma japonicum are the pathogenic agents
that cause the tropical disease schistosomiasis. Here, and in an
accompanying paper, the genomes of these two flatworms are sequenced
and analysed. The results provide insights into the molecular
architecture and host interactions of the flatworms, as well as avenues
for future development of targeted interventions for schistosomiasis.
doi:10.1038/nature08140
Abstract: http://links.ealert.nature.com/ctt?kn=208&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=181&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
The genome of the blood fluke Schistosoma mansoni pp352-358
Schistosoma mansoni and Schistosoma japonicum are the pathogenic agents
that cause the tropical disease schistosomiasis. Here, and in an
accompanying paper, the genomes of these two flatworms are sequenced
and analysed. The results provide insights into the molecular architecture
and host interactions of the flatworms, as well as avenues for future
development of targeted interventions for schistosomiasis.
Matthew Berriman et al.
doi:10.1038/nature08160
Abstract: http://links.ealert.nature.com/ctt?kn=249&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=253&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
The active form of DNA polymerase V is UmuD'2C-RecA-ATP pp359-363
Escherichia coli DNA polymerase (pol) V is involved in the mutagenic
process of limited DNA synthesis across a DNA lesion, but the molecular
composition of mutagenically active pol V and the importance of the RecA
nucleoprotein filament RecA* have remained unclear. The biochemical
role of RecA* is now defined.
Qingfei Jiang et al.
doi:10.1038/nature08178
Abstract: http://links.ealert.nature.com/ctt?kn=278&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=205&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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LETTERS
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Contamination of the asteroid belt by primordial trans-Neptunian
objects pp364-366
The main asteroid belt contains a surprising diversity of objects,
ranging from primitive ice-rock mixtures to igneous rocks. The standard
model used to explain this assumes the violent dynamical evolution of
the giant-planet orbits. Here, this evolution is shown to lead to the
insertion of primitive trans-Neptunian objects into the outer belt,
implying that the observed diversity of the asteroid belt is not a
direct reflection of the intrinsic compositional variation of the
proto-planetary disk, but rather of dynamical evolution.
Harold F. Levison et al.
doi:10.1038/nature08094
Abstract: http://links.ealert.nature.com/ctt?kn=162&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=164&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Manipulation of photons at the surface of three-dimensional photonic
crystals pp367-370
Photonic bandgap materials are envisioned to provide the necessary
tools for guiding and manipulating photons in optical circuits. So far,
basic approaches for photonic control have been based on embedding
artificial defects and light emitters inside three-dimensional materials.
Here it is demonstrated that three-dimensional photonic crystals possess
two-dimensional surface states that can easily be manipulated to control
photons, providing an alternative approach.
Kenji Ishizaki and Susumu Noda
doi:10.1038/nature08190
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=340&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Photoconductance and inverse photoconductance in films of functionalized
metal nanoparticles pp371-375
A photoconductor is a material in which electrical conductivity changes
when it is illuminated -- invariably increasing in response to impinging
light. However, here it is shown that nanoparticle-based materials can be
engineered, through the careful choice of the molecules used to stabilize
the nanoparticles, to exhibit negative photoconductance: conductivity in
these materials decreases in the presence of light.
Hideyuki Nakanishi et al.
doi:10.1038/nature08131
Abstract: http://links.ealert.nature.com/ctt?kn=349&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=290&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Evidence for middle Eocene Arctic sea ice from diatoms and ice-rafted
debris pp376-379
The presence of ice-rafted debris (IRD) in middle Eocene ocean sediments
has previously been demonstrated, but it has been unclear whether the
source of IRD was land-based glacial ice or sea ice, a distinction with
important climate implications. The analysis of a sediment core from the
ACEX project now reveals evidence that sea ice was the dominant source
for IRD from 47.5 to 45.5 million years ago.
Catherine E. Stickley et al.
doi:10.1038/nature08163
Abstract: http://links.ealert.nature.com/ctt?kn=294&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Migration of the subtropical front as a modulator of glacial climate
pp380-383
Ice cores extracted from the Antarctic ice sheet suggest that glacial
conditions and the relationship between temperatures and atmospheric
carbon dioxide concentrations have been constant over the last
800,000 years, but there is some evidence for a fluctuating severity
of glacial periods mediated by previously unidentified mechanisms.
Variable migration of the subtropical front is now shown to modulate
the severity of glacial periods, partially decoupling global climate
from atmospheric carbon dioxide concentrations.
Edouard Bard and Rosalind E. M. Rickaby
doi:10.1038/nature08189
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=323&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Global patterns of speciation and diversity pp384-387
The question of why biological diversity is spread in characteristic
patterns is perhaps the biggest problem in ecology. In recent years,
the 'neutral theory' of biodiversity has modelled the distribution
of species in a very simple way, without reference to species
interactions or history. Sexual reproduction, mutation and dispersal
are now introduced to the simulation of populations; the resulting
predictions correlate well with real data sets.
M. A. M. de Aguiar et al.
doi:10.1038/nature08168
Abstract: http://links.ealert.nature.com/ctt?kn=330&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=186&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Evolution of a malaria resistance gene in wild primates pp388-391
The study of a population of yellow baboons in Amboseli National Park
in Kenya reveals the first reported association and functional
characterization linking genetic variation and a complex trait
-- susceptibility to malaria -- in a natural population of nonhuman
primates.
Jenny Tung et al.
doi:10.1038/nature08149
Abstract: http://links.ealert.nature.com/ctt?kn=97&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=130&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Rapamycin fed late in life extends lifespan in genetically heterogeneous
mice pp392-395
Although inhibition of the TOR signalling pathway extends lifespan in
invertebrates, it was unknown whether mTOR signalling inhibition has
similar effects in mammalian species. Here, feeding mice the drug
rapamycin -- an inhibitor of the mTOR pathway -- late in life is shown
to extend lifespan by 9-14%; currently, the only way to extend lifespan
in rodents is by severe dietary restriction.
David E. Harrison et al.
doi:10.1038/nature08221
Abstract: http://links.ealert.nature.com/ctt?kn=161&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=165&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
A conserved ubiquitination pathway determines longevity in response
to diet restriction pp396-399
The fact that dietary restriction increases longevity in diverse species
suggests that there is a conserved mechanism for nutrient regulation
and prosurvival responses. The E3 ubiquitin ligase WWP-1 and the E2
ubiquitin conjugating enzyme UBC-18 are now shown to be essential for
such lifespan extension in the worm Caenorhabditis elegans.
Andrea C. Carrano, Zheng Liu, Andrew Dillin and Tony Hunter
doi:10.1038/nature08130
Abstract: http://links.ealert.nature.com/ctt?kn=153&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=237&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
A reevaluation of X-irradiation-induced phocomelia and proximodistal
limb patterning pp400-404
The condition of phocomelia, a human birth defect in which the long
bones are shorter than normal, is mimicked in developing chick limb
buds exposed to X-rays. Studies of X-irradiation-induced phocomelia
have served as evidence supporting the 'progress zone' model of limb
patterning. Here, X-irradiation-induced phocomelia is shown not to be
a patterning defect at all; rather, it results from a time-dependent
loss of skeletal progenitors.
Jenna L. Galloway, Irene Delgado, Maria A. Ros and Clifford J. Tabin
doi:10.1038/nature08117
Abstract: http://links.ealert.nature.com/ctt?kn=133&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=140&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
The AP-1 transcription factor Batf controls TH17 differentiation
pp405-409
TH17 cells comprise a subset of CD4+ T cells that coordinate the
inflammatory response in host defence but are pathogenic in
autoimmunity. Here, the AP-1 transcription factor BATF is shown to
have a critical role in TH17 cell differentiation, with Batf-/- mice
displaying a defect in TH17 differentiation and resistance to
experimental autoimmune encephalomyelitis.
Barbara U. Schraml et al.
doi:10.1038/nature08114
Abstract: http://links.ealert.nature.com/ctt?kn=166&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=152&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Cohesins form chromosomal cis-interactions at the developmentally
regulated IFNG locus pp410-413
As well as its role in sister chromatid cohesion, cohesin is thought to
have a role in the control of gene expression. Here, cohesin is shown
to form the topological and mechanistic basis for cell-type-specific
long-range chromosomal interactions at the developmentally regulated
cytokine locus IFNG.
Suzana Hadjur et al.
doi:10.1038/nature08079
Abstract: http://links.ealert.nature.com/ctt?kn=367&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=369&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
----------------------
TECHNOLOGY FEATURES
----------------------
Systems biology: Untangling the protein web pp415-418
Researchers have identified thousands of macromolecular interactions
within cells. But, as Nathan Blow finds out, joining them up in
networks and figuring out how they work still poses a big challenge.
Nathan Blow
doi:10.1038/460415a
http://links.ealert.nature.com/ctt?kn=342&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Systems biology: Playing by the rules p417
doi:10.1038/460417a
http://links.ealert.nature.com/ctt?kn=352&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Systems biology: Table of suppliers pp419-420
doi:10.1038/460419a
http://links.ealert.nature.com/ctt?kn=325&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
CAREERS Q&A
Douglas Yanega p423
Incoming member of the International Commission on Zoological
Nomenclature (ICZN) in London.
doi:10.1038/nj7253-423a
http://links.ealert.nature.com/ctt?kn=178&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
POSTDOC JOURNAL
Wealth of knowledge? p423
Life as a scientist nomad.
Sam Walcott
doi:10.1038/nj7253-423b
http://links.ealert.nature.com/ctt?kn=122&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
IN BRIEF
Energy bill to create jobs? p423
US Senate weighs in on jobs implications of energy bill.
doi:10.1038/nj7253-423c
http://links.ealert.nature.com/ctt?kn=90&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Californian budget woes p423
Eminent faculy members from the University of California warn of
budget-cut consequences.
doi:10.1038/nj7253-423d
http://links.ealert.nature.com/ctt?kn=52&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Physicists wanted p423
New posts at SLAC National Acceleratory Laboratory.
doi:10.1038/nj7253-423e
http://links.ealert.nature.com/ctt?kn=33&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
CAREERS AND RECRUITMENT
Down but not out pp424 - 425
Indian outsourcing has been hit badly by the global downturn, but signs
of growth remain. K. S. Jayaraman investigates.
doi:10.1038/nj7253-424a
http://links.ealert.nature.com/ctt?kn=16&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Makeover p428
Off on the wrong track.
James L. Cambias
doi:10.1038/460428a
http://links.ealert.nature.com/ctt?kn=305&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
15 July 2009
Proteome-wide cellular protein concentrations of the human pathogen
Leptospira interrogans
Johan Malmstrom et al.
doi:10.1038/nature08184
Abstract: http://links.ealert.nature.com/ctt?kn=309&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=315&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
13 July 2009
Switch in FGF signalling initiates glial differentiation in the
Drosophila eye
Sigridur Rut Franzdottir et al.
doi:10.1038/nature08167
Abstract: http://links.ealert.nature.com/ctt?kn=285&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=95&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Pelvic claspers confirm chondrichthyan-like internal fertilization
in arthrodires
Per Ahlberg, Kate Trinajstic, Zerina Johanson and John Long
doi:10.1038/nature08176
Abstract: http://links.ealert.nature.com/ctt?kn=185&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=146&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
EBI2 mediates B cell segregation between the outer and centre follicle
Joao P. Pereira, Lisa M. Kelly, Ying Xu and Jason G. Cyster
doi:10.1038/nature08226
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=222&m=33610836&r=MjA1NTkxMDA2MAS2&b=2&j=NTMyMzk4MjMS1&mt=1&rt=0
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