July 2009 Volume 23 Number 7, pp 1207 - 1372
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Vaccine Strategies in the 21st Century
ICB: Special Feature & Web Focus
Immunology & Cell Biology is proud to present Vaccine Strategies
in the 21st Century - a collection of articles that introduce
research on a new generation of vaccines which are logically designed
and evaluated. The accompanying web focus delves deeper into
vaccine research, placing recent discoveries into context.
Access Vaccine Strategies in the 21st Century online today!
http://links.ealert.nature.com/ctt?kn=116&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
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Why Publish in Leukemia?
Efficient peer-review, hassle-free submission, recognition...
Papers benefit from wide readership through hosting on nature.com and
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Rapid publication is also assured through Advance Online Publication.
To read the full Guide to Authors for Leukemia, visit
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SPOTLIGHT EDITORIAL
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Genomic technologies in leukemia and lymphoma: a review series
A A Ferrando
http://links.ealert.nature.com/ctt?kn=165&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
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SPOTLIGHT INTRODUCTION
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Introduction to the genomics spotlight
N Killmann
http://links.ealert.nature.com/ctt?kn=20&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
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SPOTLIGHT REVIEWS
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Genome-wide profiling of genetic alterations in acute lymphoblastic
leukemia: recent insights and future directions
C G Mullighan and J R Downing
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=168&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Toward a systems biology approach to investigate cellular networks
in normal and malignant B cells
K Basso
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Genomic approaches to small molecule discovery
K Stegmaier
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Genomic tools for dissecting oncogenic transcriptional networks
in human leukemia
T Palomero and A A Ferrando
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Chromatin maps, histone modifications and leukemia
T Neff and S A Armstrong
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=166&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Deletion 5q in myelodysplastic syndrome: a paradigm for the study
of hemizygous deletions in cancer
B L Ebert
Abstract: http://links.ealert.nature.com/ctt?kn=160&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=173&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
The role of microRNA in human leukemia: a review
S Yendamuri and G A Calin
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Induction death and treatment-related mortality in first remission
of children with acute lymphoblastic leukemia: a population-based
analysis of the Austrian Berlin-Frankfurt-Munster study group
C Prucker, A Attarbaschi, C Peters, M N Dworzak, U Potschger,
C Urban, F-M Fink, B Meister, K Schmitt, O A Haas, H Gadner and
G Mann
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
GATA-1 and GATA-2 binding to 3[prime] enhancer of WT1 gene is
essential for its transcription in acute leukemia and solid
tumor cell lines
A Furuhata, M Murakami, H Ito, S Gao, K Yoshida, S Sobue, R Kikuchi,
T Iwasaki, A Takagi, T Kojima, M Suzuki, A Abe, T Naoe and
T Murate
Abstract: http://links.ealert.nature.com/ctt?kn=100&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=181&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Effects of activating NK cell receptor expression and NK cell
reconstitution on the outcomes of unrelated donor hematopoietic
cell transplantation for hematologic malignancies
B M Triplett, E M Horwitz, R Iyengar, V Turner, M S Holladay,
K Gan, F G Behm and W Leung
Abstract: http://links.ealert.nature.com/ctt?kn=175&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=101&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Altered naive and memory CD4+ T-cell homeostasis and immunosenescence
characterize younger patients with myelodysplastic syndrome
J X Zou, D E Rollison, D Boulware, D-T Chen, E M Sloand,
L V Pfannes, J J Goronzy, F Bai, J S Painter, S Wei, D Cosgrove,
A F List and P K Epling-Burnette
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Phase II study of rabbit anti-thymocyte globulin, cyclosporine and
granulocyte colony-stimulating factor in patients with aplastic
anemia and myelodysplastic syndrome
R Garg, S Faderl, G Garcia-Manero, J Cortes, C Koller, X Huang,
S York, S Pierce, M Brandt, M Beran, G Borthakur, H Kantarjian
and F Ravandi
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=169&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct
cytogenetic entity with poor outcome and a distinct mutation
profile: comparative analysis of 493 adult patients
W-C Chou, C-Y Chen, H-A Hou, L-I Lin, J-L Tang, M Yao, W Tsay,
B-S Ko, S-J Wu, S-Y Huang, S-C Hsu, Y-C Chen, Y-N Huang, M-H Tseng,
C-F Huang and H-F Tien
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Continuous Fli-1 expression plays an essential role in the
proliferation and survival of F-MuLV-induced erythroleukemia
and human erythroleukemia
J-W Cui, L M Vecchiarelli-Federico, Y-J Li, G-J Wang and Y Ben-David
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=146&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Cyclin D1 as a universally expressed mantle cell lymphoma-associated
tumor antigen for immunotherapy
M Wang, L Sun, J Qian, X Han, L Zhang, P Lin, Z Cai and Q Yi
Abstract: http://links.ealert.nature.com/ctt?kn=180&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=154&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate
of calicheamicin, alters the levels of target molecules of
malignant B-cells
A Takeshita, N Yamakage, K Shinjo, T Ono, I Hirano, S Nakamura,
K Shigeno, T Tobita, M Maekawa, H Kiyoi, T Naoe, K Ohnishi,
Y Sugimoto and R Ohno
Abstract: http://links.ealert.nature.com/ctt?kn=128&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=118&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Cyclophosphamide, bortezomib and dexamethasone induction for
newly diagnosed multiple myeloma: high response rates in a
phase II clinical trial
C B Reeder, D E Reece, V Kukreti, C Chen, S Trudel, J Hentz,
B Noble, N A Pirooz, J E Spong, J G Piza, V H J Zepeda,
J R Mikhael, J F Leis, P L Bergsagel, R Fonseca and A K Stewart
Abstract: http://links.ealert.nature.com/ctt?kn=155&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=170&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
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LETTERS TO THE EDITOR
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Successful induction therapy with decitabine in refractory
childhood acute lymphoblastic leukemia
L Yanez, A Bermudez, C Richard, E Bureo and A Iriondo
http://links.ealert.nature.com/ctt?kn=145&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Detection of mutant TET2 in myeloid malignancies other than
myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
A Tefferi, K-H Lim, O Abdel-Wahab, T L Lasho, J Patel,
M M Patnaik, C A Hanson, A Pardanani, D G Gilliland
and R L Levine
http://links.ealert.nature.com/ctt?kn=9&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Functional characterization of an activating TEK mutation
in acute myeloid leukemia: a cellular context-dependent
activating mutation
J W Tyner, M L Rutenberg-Schoenberg, H Erickson, S G Willis,
T O'Hare, M W Deininger, B J Druker and M M Loriaux
http://links.ealert.nature.com/ctt?kn=78&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Reduced folate carrier and methylenetetrahydrofolate reductase
gene polymorphisms: associations with clinical outcome
in childhood acute lymphoblastic leukemia
L J Ashton, A J Gifford, E Kwan, A Lingwood, D T T Lau,
G M Marshall, M Haber and M D Norris
http://links.ealert.nature.com/ctt?kn=65&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Detection of p53 dysfunction in chronic lymphocytic leukaemia
cells through multiplex quantification of p53 target gene
induction
R Mous, A Jaspers, D M P Luijks, C H M Mellink, M H J van Oers,
A P Kater and E Eldering
http://links.ealert.nature.com/ctt?kn=36&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Immunoglobulin and T-cell receptor gene rearrangements as
PCR-based targets are stable markers for monitoring minimal
residual disease in acute lymphoblastic leukemia after stem
cell transplantation
H Kreyenberg, C Eckert, Y Yarkin, M Reising, A Willasch,
R Handgretinger, B Kremens, A von Stackelberg, G Henze,
T Klingebiel and P Bader
http://links.ealert.nature.com/ctt?kn=38&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
LRRFIP1, a new FGFR1 partner gene associated with 8p11
myeloproliferative syndrome
G Soler, S Nusbaum, B Varet, E A Macintyre, M Vekemans,
S P Romana and I Radford-Weiss
http://links.ealert.nature.com/ctt?kn=8&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Flow cytometric identification of acute myeloid leukemia
with limited differentiation and NPM1 type A mutation:
a new biologically defined entity
W Kern, C Haferlach, U Bacher, T Haferlach and
S Schnittger
http://links.ealert.nature.com/ctt?kn=72&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
A novel pedigree with heterozygous germline RUNX1 mutation
causing familial MDS-related AML: can these families
serve as a multistep model for leukemic transformation?
T Ripperger, D Steinemann, G Gohring, J Finke, C M Niemeyer,
B Strahm and B Schlegelberger
http://links.ealert.nature.com/ctt?kn=113&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Recombinant interferon alpha (rIFN[alpha]-2b) may retard
progression of early primary myelofibrosis
R T Silver and K Vandris
http://links.ealert.nature.com/ctt?kn=12&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
Cytoplasmic mutated nucleophosmin (NPM1) in blast crisis
of chronic myeloid leukaemia
P P Piccaluga, E Sabattini, F Bacci, C Agostinelli, S Righi,
F Salmi, N Testoni, S Paolini, F Castagnetti, G Martinelli,
B Falini and S A Pileri
http://links.ealert.nature.com/ctt?kn=31&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
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CORRIGENDUM
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CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate
of calicheamicin, alters the levels of target molecules of
malignant B-cells
A Takeshita, N Yamakage, K Shinjo, T Ono, I Hirano, S Nakamura,
K Shigeno, T Tobita, M Maekawa, H Kiyoi, T Naoe, K Ohnishi,
Y Sugimoto and R Ohno
http://links.ealert.nature.com/ctt?kn=93&m=33608105&r=MTc2MzIyNTA1NQS2&b=2&j=NTMyMTU2OTQS1&mt=1&rt=0
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