July 2009 Volume 10 Number 5, pp 373 - 545
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Nature Reviews Immunology
Focus on Neuroimmunology
Understanding the crosstalk between the nervous and immune systems and
how it can be dysregulated provides us with crucial insights necessary
for the treatment of neurological diseases such as multiple sclerosis
and Alzheimer's disease.
Nature Reviews Immunology presents a special Focus issue featuring
articles that review our current understanding of the immunopathogenesis
of and emergent immunotherapies for these neurological diseases.
Access the Focus and the accompanying library online.
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REVIEWS
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Recent insights into the genetic basis of systemic lupus erythematosus
K L Moser, J A Kelly, C J Lessard and J B Harley
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Fc[gamma] receptors: structure, function and role as genetic risk factors in SLE
X Li, T S Ptacek, E E Brown and J C Edberg
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Three checkpoints in lupus development: central tolerance in adaptive immunity,
peripheral amplification by innate immunity and end-organ inflammation
H Kanta and C Mohan
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Genetic associations of LYN with systemic lupus erythematosus
R Lu, G S Vidal, J A Kelly, A M Delgado-Vega, X K Howard, S R Macwana, N Dominguez,
W Klein, C Burrell, I T Harley, K M Kaufman, G R Bruner, K L Moser, P M Gaffney,
G S Gilkeson, E K Wakeland, Q-Z Li, C D Langefeld, M C Marion, J Divers, G S Alarcon,
E E Brown, R P Kimberly, J C Edberg, R Ramsey-Goldman, J D Reveille, G McGwin Jr,
L M Vila, M A Petri, S-C Bae, S-K Cho, S-Y Bang, I Kim, C-B Choi, J Martin, T J Vyse,
J T Merrill, J B Harley, M E Alarcon-Riquelme, S K Nath, J A James and J M Guthridge
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE
D L Morris, R R Graham, L-P Erwig, P M Gaffney, K L Moser, T W Behrens,
T J Vyse and D S Cunninghame Graham
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese
Y K Chang, W Yang, M Zhao, C C Mok, T M Chan, R W S Wong, K W Lee, M Y Mok, S N Wong,
I O L Ng, T L Lee, M H K Ho, P P W Lee, W H S Wong, C S Lau, P C Sham and Y L Lau
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Genetic studies of systemic lupus erythematosus in Asia: where are we now?
I Kim, Y J Kim, K Kim, C Kang, C-B Choi, Y-K Sung, H-S Lee and S-C Bae
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Molecular basis of complete complement C4 deficiency in two North-African families
with systemic lupus erythematosus
Y L Wu, G Hauptmann, M Viguier and C Y Yu
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Identification of new SLE-associated genes with a two-step Bayesian study design
D L Armstrong, A Reiff, B L Myones, F P Quismorio, M Klein-Gitelman, D McCurdy,
L Wagner-Weiner, E Silverman, J O Ojwang, K M Kaufman, J A Kelly, J T Merrill,
J B Harley, S-C Bae, T J Vyse, G S Gilkeson, P M Gaffney, K L Moser, C Putterman,
J C Edberg, E E Brown, J Ziegler, C D Langefeld, R Zidovetzki and C O Jacob
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Complement receptor 2 polymorphisms associated with systemic lupus erythematosus
modulate alternative splicing
K B Douglas, D C Windels, J Zhao, A V Gadeliya, H Wu, K M Kaufman, J B Harley,
J Merrill, R P Kimberly, G S Alarcon, E E Brown, J C Edberg, R Ramsey-Goldman,
M Petri, J D Reveille, L M Vila, P M Gaffney, J A James, K L Moser, M E Alarcon-Riquelme,
T J Vyse, G S Gilkeson, C O Jacob, J T Ziegler, C D Langefeld, D Ulgiati, B P Tsao and S A Boackle
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Meta-analysis and imputation identifies a 109[thinsp]kb risk haplotype spanning
TNFAIP3 associated with lupus nephritis and hematologic manifestations
J S Bates, C J Lessard, J M Leon, T Nguyen, L J Battiest, J Rodgers, K M Kaufman,
J A James, G S Gilkeson, J A Kelly, M B Humphrey, J B Harley, C Gray-McGuire,
K L Moser and P M Gaffney
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
46,X,del(X)(q13) Turner's syndrome women with systemic lupus erythematosus
in a pedigree multiplex for SLE
C M Cooney, G R Bruner, T Aberle, B Namjou-Khales, L K Myers, L Feo, S Li,
A D'Souza, A Ramirez, J B Harley and R H Scofield
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
A regulatory SNP at position -899 in CDKN1A is associated with systemic lupus
erythematosus and lupus nephritis
K Kim, Y-K Sung, C P Kang, C-B Choi, C Kang and S-C Bae
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Age- and gender-specific modulation of serum osteopontin and interferon-[alpha] by
osteopontin genotype in systemic lupus erythematosus
S N Kariuki, J G Moore, K A Kirou, M K Crow, T O Utset and T B Niewold
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis
R Kaiser, J L Barton, M Chang, J J Catanese, Y Li, A B Begovich and L A Criswell
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis
Q-Z Li, J Zhou, R Yang, M Yan, Q Ye, K Liu, S Liu, X Shao, L Li, X-J Zhou, E K Wakeland and C Mohan
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis
A Hewagama, D Patel, S Yarlagadda, F M Strickland and B C Richardson
Abstract: http://links.ealert.nature.com/ctt?kn=65&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Evaluation of C1q genomic region in minority racial groups of lupus
B Namjou, C Gray-McGuire, A L Sestak, G S Gilkeson, C O Jacob, J T Merrill,
J A James, E K Wakeland, Q-Z Li, C D Langefeld, J Divers, J Ziegler, K L Moser,
J A Kelly, K M Kaufman and J B Harley
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
The heritability and genetics of complement C3 expression in UK SLE families
B Rhodes, S Hunnangkul, D L Morris, L-C Hsaio, D S Cunninghame Graham, D Nitsch,
J C Whittaker and T J Vyse
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Replication of the BANK1 genetic association with systemic lupus erythematosus
in a European-derived population
L Guo, H Deshmukh, R Lu, G S Vidal, J A Kelly, K M Kaufman, N Dominguez,
W Klein, X Kim-Howard, G R Bruner, R H Scofield, K L Moser, P M Gaffney,
I M Dozmorov, G S Gilkeson, E K Wakeland, Q-Z Li, C D Langefeld, M C Marion,
A H Williams, J Divers, G S Alarcon, E E Brown, R P Kimberly, J C Edberg,
R Ramsey-Goldman, J D Reveille, G McGwin, L M Vila, M A Petri, T J Vyse,
J T Merrill, J A James, S K Nath, J B Harley and J M Guthridge
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Admixture in Hispanic Americans: its impact on ITGAM association and implications
for admixture mapping in SLE
J E Molineros, X Kim-Howard, H Deshmukh, C O Jacob, J B Harley and S K Nath
Abstract: http://links.ealert.nature.com/ctt?kn=51&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=33677102&r=MTc2MTE2NTAwMwS2&b=2&j=NTM2NzE1MjAS1&mt=1&rt=0
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Vaccine Strategies in the 21st Century
ICB: Special Feature & Web Focus
Immunology & Cell Biology is proud to present Vaccine Strategies in the
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