Signaling Gateway - 26 June 2009
http://links.ealert.nature.com/ctt?kn=57&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=59&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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NEURONAL STEM CELLS: LESS NOTCH, MORE NEURONS
Epidermal growth factor-like domain 7 (EGFL7) antagonizes Notch
signaling to limit neural stem cell self renewal and promote
neurogenesis.
Original research paper: Nature Cell Biology advance
online publication, 7 June 2009
http://links.ealert.nature.com/ctt?kn=39&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
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Molecule Pages
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Chk2
http://links.ealert.nature.com/ctt?kn=55&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
The tumor suppressor Chk2 is a Serine/Threonine checkpoint protein
kinase that along with Chk1 regulates the cellular response to DNA
damage. Upon phosphorylation and activation by the upstream
sensor-associated kinases ATM (ataxia telangiectasia mutated) and
ATR (ATM and Rad3-related), Chk2 amplifies the DNA damage signal by
phosphorylating several substrates that mediate cell-cycle arrest,
DNA repair and apoptosis.
also published this week: Psgr
http://links.ealert.nature.com/ctt?kn=4&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=41&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
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Selected Updates
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THERAPY: FGFR3 IS KEY
The growth of bladder cancer tumors that express mutant FGFR3 can be
blocked by monoclonal antibodies targeting the mutant protein.
Original research paper: J. Clin. Invest. 119, 1216-1229 (2009)
http://links.ealert.nature.com/ctt?kn=54&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
CHEMICAL SENSES: SNIFFING OUT DISEASE
Formyl peptide receptor (FPR) gene family members that are expressed
in sensory neurons in the vomeronasal organ can detect molecules
related to disease or inflammation.
Original research paper: Nature, 22 Apr 2009
(doi: 10.1038/nature08029)
http://links.ealert.nature.com/ctt?kn=15&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
CELLULAR MICROBIOLOGY: EXAMINING THE FIC DOMAIN
Fic domain-containing proteins are a novel class of enzymes that can
both mediate bacterial pathogenesis and add an AMP moiety to a
conserved tyrosine residue in the switch I region of RhoA,
Rac and Cdc42.
Original research paper: Mol. Cell 34, 93-103 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=48&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=10&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
GOLPH3 MODULATES MTOR SIGNALLING AND RAPAMYCIN SENSITIVITY IN CANCER
Nature 459, 1085-1090 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
P53 CONTROLS CANCER CELL INVASION BY INDUCING THE MDM2-MEDIATED
DEGRADATION OF SLUG
Nature Cell Biology 11, 694-704 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
RAG-1 AND ATM COORDINATE MONOALLELIC RECOMBINATION AND NUCLEAR
POSITIONING OF IMMUNOGLOBULIN LOCI
Nature Immunology 10, 655-664 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
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Signaling News
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HEART STUDY QUESTIONS DIABETES DRUGS
http://links.ealert.nature.com/ctt?kn=24&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
A class of diabetes drugs called thiazolidinediones (TZDs) increases
the risk of heart failure, and researchers have now shown that TZDs
activate the transcription factor peroxisome proliferator activated
receptor gamma (PPAR-gamma). High levels of PPAR-gamma have been
detected in cardiac tissue from people with cardiac hypertrophy,
which might help explain the link between TZDs and heart failure.
More news
http://links.ealert.nature.com/ctt?kn=17&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - JUNE UPDATE
http://links.ealert.nature.com/ctt?kn=14&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update includes "Making a brain: Without sugar, NCAM
can't" and "Virus neutralization: Sweet antibodies have more bite".
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=30&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
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Job of the Week
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Senior postdoctoral position
Employer: Goethe-University Frankfurt
Location: Frankfurt am Main, Germany
http://links.ealert.nature.com/ctt?kn=29&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
A senior postdoctoral position is available at the Institute for
Cardiovascular Physiology at Goethe-University Frankfurt.
The successful applicant will study signal transduction elicited by
fatty acid metabolites and the role of these compounds in the
pathogenesis of vascular remodeling, hypertension and angiogenesis.
More Jobs:
http://links.ealert.nature.com/ctt?kn=13&m=33471436&r=MTc2ODc4NDI0MAS2&b=2&j=NTIxNDcyNjQS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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