July 2009 Volume 5 Number 7
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=========================== ADVERTISEMENT ===========================
ISN Nexus Symposium: The Kidney and the Vascular System: Emerging Culprits
in Pathogenesis and Advances in Therapy.
April 15-18, 2010; Kyoto (Japan)
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=========================== ADVERTISEMENT ===========================
Hot article from Journal of Human Hypertension:
Obstructive sleep apnoea syndrome is associated with enhanced sub-clinical
inflammation and asymmetric dimethyl-arginine levels in hypertensives
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EDITORIAL
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The fallacy of 'alternative' medicine
Chloe Harman
p361 | doi:10.1038/nrneph.2009.96
http://links.ealert.nature.com/ctt?kn=55&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Dialysis: AURORA confirms lack of statin benefit in dialysis patients
p363 | doi:10.1038/nrneph.2009.79
http://links.ealert.nature.com/ctt?kn=10&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Hypertension: RF ablation of renal nerves
p364 | doi:10.1038/nrcardio.2009.63
http://links.ealert.nature.com/ctt?kn=79&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
High cut-off dialysis in myeloma
p364 | doi:10.1038/nrneph.2009.80
http://links.ealert.nature.com/ctt?kn=24&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Transplantation: Immunosuppression tapering in HLA-identical transplantation
p365 | doi:10.1038/nrneph.2009.83
http://links.ealert.nature.com/ctt?kn=18&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
IN BRIEF
Transplantation | Anemia | Transplantation | Hypertension
p365 | doi:10.1038/nrneph.2009.84
http://links.ealert.nature.com/ctt?kn=33&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Dialysis: Autologous grafts offer vascular access hope
p366 | doi:10.1038/nrneph.2009.82
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IN BRIEF
Transplantation | Pediatrics | Transplantation | Chronic kidney disease
p366 | doi:10.1038/nrneph.2009.85
http://links.ealert.nature.com/ctt?kn=28&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
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NEWS AND VIEWS
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Proteinuria: Increased angiotensin-receptor blocking is not the first
option
Piero Ruggenenti, Paolo Cravedi and Giuseppe Remuzzi
p367 | doi:10.1038/nrneph.2009.77
Candesartan doses in excess of the recommended antihypertensive maxima
have been reported to lead to greater reductions of proteinuria than
the advised doses. High-dose angiotensin-converting-enzyme inhibitors,
however, are at least as effective as high-dose angiotensin blockers
and less expensive. Angiotensin-converting-enzyme inhibition is thus
the first-line strategy to halt kidney disease progression.
http://links.ealert.nature.com/ctt?kn=68&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Dialysis: Phosphorus binders and survival: need for randomized trials
Joachim H. Ix and Glenn M. Chertow
p368 | doi:10.1038/nrneph.2009.78
An observational study suggests that administration of phosphorus binders
dramatically improves survival rates in patients on incident
hemodialysis-even in those without hyperphosphatemia. Randomized clinical
trials should drive changes in the relevant clinical practice.
http://links.ealert.nature.com/ctt?kn=87&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Diabetes: Renal benefits of lowering BP in the absence of hypertension
Hiromichi Suzuki
p370 | doi:10.1038/nrneph.2009.92
Regardless of baseline blood pressure, treatment with a combination of an
angiotensin-converting enzyme inhibitor and a diuretic decreases incidence
of renal events in patients with type 2 diabetes. The combination therapy
approach could be the key to achieving renoprotection.
http://links.ealert.nature.com/ctt?kn=80&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Transplantation: To convert or not to convert: lessons from the CONVERT trial
Suphamai Bunnapradist and Flavio Vincenti
p371 | doi:10.1038/nrneph.2009.94
In participants of the CONVERT trial, which enrolled recipients of kidney
transplants, conversion of immunosuppressive therapy from calcineurin
inhibitors to sirolimus did not improve renal function. More importantly,
the intervention was detrimental among patients with impaired kidney
function and/or proteinuria. Sirolimus conversion resulted, however,
in lower rates of malignancy.
http://links.ealert.nature.com/ctt?kn=96&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
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REVIEWS
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Emerging therapies for chronic kidney disease: what is their role?
Eswari Vilayur and David C. H. Harris
Published online: 19 May 2009
p375 | doi:10.1038/nrneph.2009.76
The prevalence of chronic kidney disease (CKD) is increasing worldwide.
The best therapies currently available aim to control blood pressure
and maximize renin-angiotensin-aldosterone system blockade but are only
partially effective in humans. A number of emerging therapies have shown
benefit in animal models of CKD, and some have been tested to a limited
extent in humans. This Review examines these emerging pharmacological
strategies in the context of diabetic nephropathy, diabetic and nondiabetic
CKD and autosomal dominant polycystic kidney disease.
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=2&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Sexual dimorphism in the aging kidney: differences in the nitric oxide system
Chris Baylis
Published online: 02 June 2009
p384 | doi:10.1038/nrneph.2009.90
Glomerular filtration rate usually decreases with advancing age as a result
of structural and functional changes in the aging kidney, but women are
substantially protected against the age-dependent decline in renal function.
This sexual dimorphism is the product of differences in chromosomes,
perinatal programming and gonadal hormones (sex steroids) that create
sexual phenotype. In this Review, Chris Baylis focuses on the role of
the sex steroids, with a particular emphasis on the effects of sex and
age on the nitric oxide system.
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Integrating albuminuria and GFR in the assessment of diabetic nephropathy
George Jerums, Sianna Panagiotopoulos, Erosha Premaratne and
Richard J. MacIsaac
p397 | doi:10.1038/nrneph.2009.91
The evaluation of diabetic nephropathy from both research and clinical
viewpoints depends on the assessment of two continuous variables, albumin
excretion rate (AER) and glomerular filtration rate (GFR). Although
increases in AER generally precede a decline in GFR, some patients follow
a non-albuminuric pathway to renal impairment. In this Review, George
Jerums and colleagues explain why serial assessments of both AER and GFR
should be performed at an early stage in patients being evaluated for
diabetic nephropathy.
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Circadian sleep-wake rhythm disturbances in end-stage renal disease
Birgit C. P. Koch, J. Elsbeth Nagtegaal, Gerard A. Kerkhof and
Piet M. ter Wee
Published online: 26 May 2009
p407 | doi:10.1038/nrneph.2009.88
Sleep disturbances are much more prevalent in the dialysis population
than in the general population, and have a major effect on the vitality
and general health of these patients. In this Review, Koch and colleagues
discuss circadian sleep-wake rhythm disturbances in individuals with
end-stage renal disease. The possible external and internal influences
on sleep-wake rhythmicity in such patients-such as the effect of dialysis,
medications, melatonin and biochemical parameters-are presented, and
possible approaches for strengthening the synchronization of the circadian
sleep-wake rhythm are explored.
Abstract: http://links.ealert.nature.com/ctt?kn=97&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
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CASE STUDY
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Malacoplakia presenting with obstructive nephropathy with bilateral ureter
involvement
Lorin M. Sanchez, Sean I. Sanchez and James L. Bailey
p418 | doi:10.1038/nrneph.2009.86
The lesions associated with the rare granulomatosus disease malacoplakia,
which can result in serious complications, are often mistaken for renal
abscesses or malignant growths. Sanchez and colleagues describe the
presentation of a woman whose malacoplakia involved both ureters and
the bladder and required the placement of bilateral percutaneous
nephrostomy tubes.
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Weibel-Palade bodies[mdash]sentinels of acute stress
Michael S. Goligorsky, Daniel Patschan and Mei-Chuan Kuo
p423 | doi:10.1038/nrneph.2009.87
Weibel-Palade bodies, organelles of storage and secretion in endothelial
cells, harbor a range of bioactive substances, including von Willebrand
factor, angiopoietin 2, and interleukin 8. The authors of this Perspectives
article examine the biogenesis and exocytosis of Weibel-Palade bodies and
propose that these organelles could have key roles in the development of
endothelial dysfunction and as a first-line response to acute stressors
such as ischemia.
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=33471331&r=MTc2NDE4ODIzOQS2&b=2&j=NTIxNDYwNjcS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Hot article from Journal of Human Hypertension:
A community based study explores the association between the RAS gene
polymorphisms and essential hypertension.
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