June 2009 Volume 6 Number 6
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RESEARCH HIGHLIGHTS
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BPH: Diathermy vaporization a more cost-effective initial intervention
than TURP
p291 | doi:10.1038/nrurol.2009.70
http://links.ealert.nature.com/ctt?kn=37&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Imaging: ERC impacts on prostate radiotherapy
p292 | doi:10.1038/nrurol.2009.85
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Prostate cancer: Hormonal therapy for life?
p292 | doi:10.1038/nrurol.2009.90
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Adjuvant radiotherapy: no survival benefit?
p293 | doi:10.1038/nrurol.2009.69
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Sexual dysfunction: Topical spray treatment for premature ejaculation
p294 | doi:10.1038/nrurol.2009.88
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IN BRIEF
Male factor infertility | Stones | BPH | Imaging
p294 | doi:10.1038/nrurol.2009.91
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Sexual dysfunction: T-shunt relieves priapism
p295 | doi:10.1038/nrurol.2009.86
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Testicular cancer: RPLND an effective first-line alternative to chemotherapy
p295 | doi:10.1038/nrurol.2009.87
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Promising new antiandrogens
p296 | doi:10.1038/nrurol.2009.67
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Andrology: Potential for diagnostic errors in men taking statins
p296 | doi:10.1038/nrurol.2009.89
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NEWS AND VIEWS
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Clinical trials: 'Clinical integration': laudable, but challenging
E. David Crawford and Catherine M. Tangen
p297 | doi:10.1038/nrurol.2009.97
We need a fresh approach to conducting clinical trials. Our present system
is in serious need of an overhaul. Regulatory guidelines need to be
re-evaluated, as they present significant barriers and cause delays.
http://links.ealert.nature.com/ctt?kn=55&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Infectious disease: Male circumcision for preventing HPV infection
Ronald H. Gray
p298 | doi:10.1038/nrurol.2009.96
The role of male circumcision in reducing sexually transmitted infections
is controversial. A series of recently published papers add to the growing
body of evidence that male circumcision might reduce carriage of penile
human papillomavirus (HPV).
http://links.ealert.nature.com/ctt?kn=70&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Prostate cancer: To screen or not to screen?
Urs E. Studer and Laurence Collette
p299 | doi:10.1038/nrurol.2009.92
Unfortunately, interim analyses of the long-awaited ERSPC and PLCO trial
data have generated conflicting conclusions. Here, two European authors
speculate as to the reasons underlying this contradiction, while highlighting
clinically relevant points that are supported by both studies. Particular
attention is paid to the potential consequences of overdiagnosis and
overtreatment.
http://links.ealert.nature.com/ctt?kn=38&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Prostate cancer: Estimating the benefits of PSA screening
Andrew J. Vickers and Hans Lilja
p301 | doi:10.1038/nrurol.2009.95
Two groundbreaking trials have this year reported conflicting results
as to the benefit of screening for prostate cancer. Careful interpretation
in the light of contemporary data is needed to reveal the value of this
intervention.
http://links.ealert.nature.com/ctt?kn=86&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Prostate cancer: WHO standardization of PSA tests: clinical consequences
Carsten Stephan
p303 | doi:10.1038/nrurol.2009.94
The introduction of WHO standards for PSA assays is a step forward for
improving the comparability of these tests. Our current clinical decision
limits, however, were validated using traditional calibrators. The threshold
for biopsy must be adjusted when using the new standards.
http://links.ealert.nature.com/ctt?kn=73&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Prostate cancer: Is PSA velocity useful?
Stacy Loeb
p305 | doi:10.1038/nrurol.2009.93
When a patient presents for assessment of prostate cancer risk, do serial
measurements of PSA provide more-useful information than determination
of a single PSA concentration? The authors of a new systematic review
contend that the answer to this question is 'no'. Stacy Loeb cautions
against hasty abandonment of PSA kinetics.
http://links.ealert.nature.com/ctt?kn=81&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
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REVIEWS
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Management of duplex system ureteroceles in neonates and infants
Marco Castagnetti and Alaa El-Ghoneimi
p307 | doi:10.1038/nrurol.2009.82
The variable nature of duplex system ureteroceles, combined with the
lack of controlled trials assessing their treatment, makes them a
challenging prospect to urologists. Balancing potential risks of treatment
against predicted outcomes is paramount, with the aim of minimizing the
likelihood of urinary tract infections, preserving existing functionality,
and preventing bladder dysfunction and incontinence.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Molecular imaging of prostate cancer with 18F-fluorodeoxyglucose PET
Hossein Jadvar
Published online: 12 May 2009
p317 | doi:10.1038/nrurol.2009.81
Molecular evidence indicates that 18F-labeled 2-fluoro-2-deoxy-D-glucose
(FDG) accumulates in prostate tumors. Hossein Jadvar from the University
of Southern California summarizes these data, and provides an overview of
imaging techniques currently used to evaluate various aspects of prostate
cancer, before outlining current clinical experience of FDG-PET for the
evaluation of this disease.
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Proton radiation for localized prostate cancer
John J. Coen and Anthony L. Zietman
Published online: 12 May 2009
p324 | doi:10.1038/nrurol.2009.83
Drawing on their own considerable experience, Coen and Zietman from Harvard
Medical School assess the current clinical utility of proton beam therapy
for prostatic malignancy. Comparison with other approaches such as
intensity-modulated radiation therapy highlights the potential of this
promising but expensive modality.
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
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CASE STUDIES
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A case of adult acute idiopathic scrotal edema
Desmond G. S. Ooi, Mui Teng Chua and Lincoln G. L. Tan
p331 | doi:10.1038/nrurol.2009.80
Here, Ooi and co-workers present a 40-year-old man who developed acute-onset
bilateral painless swelling of the scrotum, and was diagnosed with acute
idiopathic scrotal edema. Although rare in adult males, this condition
should be considered in the differential diagnosis of acute scrotal
swellings, in order to avoid unnecessary surgery.
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=9&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Endovascular management of grade V blunt renal trauma with associated
splenic injury
Arun Sahai, Faye Cuthbert, Ramon Niekrash, Midhat Siddiqui and Manpreet
Singh Gulati
p335 | doi:10.1038/nrurol.2009.79
In this Case Study, Sahai and colleagues report on a 15-year-old boy
who sustained grade V renal trauma, with associated splenic injury and
renal vein thrombosis. The authors use the case to illustrate that
conservative management of grade V blunt renal trauma is possible in a
hemodynamically stable patient.
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Laparoscopic radical nephrectomy after shrinkage of a caval tumor thrombus
with sunitinib
Lauren C. Harshman, Sandy Srinivas, Aya Kamaya and Benjamin I. Chung
p338 | doi:10.1038/nrurol.2009.84
The authors present a 57-year-old woman with advanced renal cell carcinoma
(RCC) and a tumor thrombus extending into the vena cava. She received
neoadjuvant sunitinib, which shrank the tumor thrombus, and enabled
laparoscopic radical nephrectomy to be performed. The case highlights the
potential of targeted agents before surgery in RCC.
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=33359013&r=MTc2NDg0NjM5NAS2&b=2&j=NTA4ODcxOTAS1&mt=1&rt=0
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