Signaling Gateway - 29 May 2009
http://links.ealert.nature.com/ctt?kn=34&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=25&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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IMMUNE SIGNALING: FUNGUS MAKES CELLS SYK
Following fungal infection, Syk signaling activates Nlrp3-containing
inflammasomes to produce the interleukin IL-1beta.
Original research paper: Nature 459, 433-436 (2009)
http://links.ealert.nature.com/ctt?kn=13&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
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Selected Updates
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AUTOPHAGY: BREAKING AND EXITING
Autophagy contributes to the establishment of Ras-induced senescence
in part by facilitating the rapid turnover of the pro-senescent
cytokines interleukin 6 (IL-6) and IL-8.
Original research paper: Genes Dev. 23, 798–803 (2009)
http://links.ealert.nature.com/ctt?kn=35&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
ANTIPLATELET DRUGS: IMPROVING THE THERAPEUTIC WINDOW
A ligand-based design strategy targeting a G-protein-coupled receptor
(GPCR) expressed on platelets has been used to identify a novel
antiplatelet agent that does not prolong bleeding.
Original research paper: ACS Chem. Biol. 4, 115-126 (2009)
http://links.ealert.nature.com/ctt?kn=5&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
VIRAL IMMUNE EVASION: INTERFERON INTERFERENCE
A Kaposi's sarcoma-associated herpesvirus (KSHV) protein called RIF
inhibits interferon signaling by decreasing interferon-stimulated
phosphorylation of STAT1, STAT2, JAK and LTK.
Original research paper: J. Virol. 83, 5056-5066 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=16&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=26&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
IRREVERSIBILITY OF MITOTIC EXIT IS THE CONSEQUENCE OF SYSTEMS-LEVEL
FEEDBACK
Nature 459, 592-595 (2009)
http://links.ealert.nature.com/ctt?kn=32&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
KRAB-TYPE ZINC-FINGER PROTEIN APAK SPECIFICALLY REGULATES
p53-DEPENDENT APOPTOSIS
Nature Cell Biology 11, 580-591 (2009)
http://links.ealert.nature.com/ctt?kn=21&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
ADJUVANT IL-7 ANTAGONIZES MULTIPLE CELLULAR AND MOLECULAR INHIBITORY
NETWORKS TO ENHANCE IMMUNOTHERAPIES
Nature Medicine 15, 528-536 (2009)
http://links.ealert.nature.com/ctt?kn=36&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
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Signaling News
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A CHANGE OF STRATEGY IN THE WAR ON CANCER
http://links.ealert.nature.com/ctt?kn=11&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
Patients and politicians anxiously await and increasingly demand
a 'cure' for cancer. But Robert A. Gatenby suggests that trying to
control the disease may prove a better plan than striving to cure it.
More news
http://links.ealert.nature.com/ctt?kn=29&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
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Gateway Updates
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NATURE REPORTS STEM CELLS – MAY UPDATE
http://links.ealert.nature.com/ctt?kn=12&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
Nature Reports Stem Cells aims to enlighten and promote communication
in stem cell research by delivering stem cell science and news to
your desktop.
This month's update includes an interview with Elaine Fuchs on the
secrets of skin renewal and a feature on the role of microRNA in
repression of pluripotency.
http://links.ealert.nature.com/ctt?kn=12&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
Sign up to receive the monthly newsletter from
Nature Reports Stem Cells
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Job of the Week
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Career Development Fellow
Employer: MRC Protein Phosphorylation Unit
Location: Dundee, UK
http://links.ealert.nature.com/ctt?kn=10&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
Applications are invited for the position of Career Development
Fellow at the Medical Research Council (MRC) Protein Phosphorylation
Unit. The successful candidate will work with Professor Dario Alessi
on understanding the functions of protein kinases such as LKB1, WNK
and LRRK2 that are mutated in inherited disorders, and how to exploit
this information to develop improved treatments for disease.
More Jobs:
http://links.ealert.nature.com/ctt?kn=2&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=23&m=33291713&r=MTc2ODc4NDI0MAS2&b=2&j=NTA0MDkwMDIS1&mt=1&rt=0
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