Signaling Gateway - 22 May 2009
http://links.ealert.nature.com/ctt?kn=35&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=37&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
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In Signaling Update this week:
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Featured Article
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IMMUNE SIGNALING: PLAYING TAG IN THE ENDOSOMES
TAG, a splice variant of the Toll-like receptor (TLR) adaptor protein
TRAM, negatively regulates TLR4 signaling in late endosomes.
Original research paper: Nature Immunology 10, 579-586 (2009)
http://links.ealert.nature.com/ctt?kn=13&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
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Molecule Pages
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Pak2
http://links.ealert.nature.com/ctt?kn=19&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
Pak2 is a member of the Pak family of serine-threonine kinases.
Pak proteins are activated by the small GTPases Rac and Cdc42 in
response to growth factors or chemotactic agents. Pak2 is unique
among the Pak isoforms because it is activated as a full-length
enzyme and as a proteolytic Pak2p34 fragment in response to stress
stimuli. Activation of full-length Pak2 stimulates cell survival,
whereas activation of Pak2p34 is involved in programmed cell death.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=5&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
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Selected Updates
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DNA DAMAGE RESPONSE: CHANGE OF GUARD AT THE CHECKPOINT
Resectioning double-stranded DNA breaks (DSBs) promotes a switch
between the activation of ATM and the subsequent activation of ATR.
Original research paper: Mol. Cell 13, 547–558 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
IMMUNOTHERAPY: A HIDDEN TARGET
Tumor-associated epidermal growth factor receptor (EGFR) is
specifically targeted by antibodies that recognize a cryptic epitope
that is not accessible on EGFR derived from wild-type cells.
Original research paper: Proc. Natl Acad. Sci. USA 106,
5082-5087 (2009)
http://links.ealert.nature.com/ctt?kn=36&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
NEUROSCIENCE: DAWN ON THE MICE
Light-gated ion channels and modified G-protein-coupled receptors can
be activated by directly delivering light deep into the brain.
Original research paper: Nature 458, 1025-1029 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=29&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=16&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
PEP1 REGULATES PERENNIAL FLOWERING IN ARABIS ALPINA
Nature 459, 423-427 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
BRAFV600E COOPERATES WITH PTEN LOSS TO INDUCE METASTATIC MELANOMA
Nature Genetics 41, 544-552 (2009)
http://links.ealert.nature.com/ctt?kn=20&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
EMBRYONIC STEM CELL-SPECIFIC MICRORNAs PROMOTE INDUCED PLURIPOTENCY
Nature Biotechnology 27, 459-461 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
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Signaling News
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WHY DOWN'S PATIENTS SUFFER FEWER CANCERS
http://links.ealert.nature.com/ctt?kn=30&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
The extra copy of chromosome 21 in people with Down's syndrome
causes the developmental disabilities associated with the disease.
However, the additional third copy of the genes Dscr1
(also known as Rcan1) and Dyrk1a on chromosome 21 can suppress
angiogenesis by attenuating VEGF-calcineurin-NFAT signaling.
This finding could help explain the lower incidence of many cancers
in individuals with Down's syndrome.
More news
http://links.ealert.nature.com/ctt?kn=24&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - MAY UPDATE
http://links.ealert.nature.com/ctt?kn=18&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update includes features on GlcNAcylation and
chondroitin sulfate.
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=32&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
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Job of the Week
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Postdoctoral fellow position
Employer: Chinese Academy of Sciences
Location: Shanghai, China
http://links.ealert.nature.com/ctt?kn=12&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
A postdoctoral fellow position is available in Dr. Chenqi Xu's
laboratory at the Institute of Biochemistry and Cell Biology in the
Chinese Academy of Sciences to study the structure and function of
key immunoreceptors in T-cell signaling. The successful candidate
should have a strong background in protein chemistry or immunology.
More Jobs:
http://links.ealert.nature.com/ctt?kn=3&m=33136614&r=MTc2ODc4NDI0MAS2&b=2&j=NDk5NTY0MjcS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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