June 2009 Volume 9 Number 6
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This month's FEATURED article:
Autoimmune T cell responses in the central nervous system
Joan Goverman
p393 | doi:10.1038/nri2550
http://links.ealert.nature.com/ctt?kn=20&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
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From the editors
p385 | doi:10.1038/nri2585
http://links.ealert.nature.com/ctt?kn=55&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Neuroimmunology: Finding a way into the brain
p386 | doi:10.1038/nri2549
http://links.ealert.nature.com/ctt?kn=52&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
T cell differentiation: The TH1 two step
p387 | doi:10.1038/nri2571
http://links.ealert.nature.com/ctt?kn=4&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
IN THE NEWS
Cladribine hope for multiple sclerosis
p387 | doi:10.1038/nri2579
http://links.ealert.nature.com/ctt?kn=18&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
T cells: Helper cell metamorphosis
p388 | doi:10.1038/nri2577
http://links.ealert.nature.com/ctt?kn=32&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Tumour immunology: Attacking the enabler
p388 | doi:10.1038/nri2581
http://links.ealert.nature.com/ctt?kn=42&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
IN BRIEF
Immunogenetics | Parasite immunity | Neuroimmunology
p388 | doi:10.1038/nri2583
http://links.ealert.nature.com/ctt?kn=10&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
IN BRIEF
Parasite immunity | Autoimmunity | Lymphocyte migration
p389 | doi:10.1038/nri2584
http://links.ealert.nature.com/ctt?kn=15&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Autoimmunity: A new target in multiple sclerosis?
p390 | doi:10.1038/nri2574
http://links.ealert.nature.com/ctt?kn=38&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Inflammation: Targeting TNF
p390 | doi:10.1038/nri2578
http://links.ealert.nature.com/ctt?kn=95&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Neuroimmunology: Basement membrane laminins guard the CNS
p391 | doi:10.1038/nri2576
http://links.ealert.nature.com/ctt?kn=35&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
T cell memory: A new resting place
p392 | doi:10.1038/nri2573
http://links.ealert.nature.com/ctt?kn=24&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Antiviral immunity: IL-21: in it for the long run
p392 | doi:10.1038/nri2582
http://links.ealert.nature.com/ctt?kn=9&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
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Focus on: Neuroimmunology
http://links.ealert.nature.com/ctt?kn=89&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
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REVIEWS
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Autoimmune T cell responses in the central nervous system
Joan Goverman
p393 | doi:10.1038/nri2550
Our understanding of the role of T cells in the induction of
autoimmune disease in the central nervous system has progressed
rapidly in recent years. Here, Joan Goverman provides us with a
comprehensive overview of this field and discusses the controversies
that remain.
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
From genes to function: the next challenge to understanding multiple
sclerosis
Lars Fugger, Manuel A. Friese and John I. Bell
p408 | doi:10.1038/nri2554
With recent studies revealing the genetic determinants of multiple
sclerosis, our attention must now turn to defining the function of
the candidate genes in disease pathogenesis. This Review describes
our progress so far and the approaches required to tease out the
contribution made by multiple genetic and environmental factors.
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Reflex control of immunity
Kevin J. Tracey
p418 | doi:10.1038/nri2566
Work in the past decade has revealed the role of neural circuits in
modulating inflammatory conditions. Here, Kevin Tracey discusses the
inflammatory reflex, and in particular the efferent arc of this
reflex, which is known as the cholinergic anti-inflammatory pathway.
In this pathway, acetylcholine activity suppresses the release of
pro-inflammatory cytokines.
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Regulation of innate immune responses in the brain
Serge Rivest
p429 | doi:10.1038/nri2565
In this Review article, Serge Rivest discusses how microglial cells
(the resident innate immune cells of the central nervous system) are
activated during infection and injury, whether microglial cell
activation is neurodestructive or neuroprotective, and how targeting
these cells could be a therapeutic approach for the treatment of
Alzheimer's disease.
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
A molecular trio in relapse and remission in multiple sclerosis
Lawrence Steinman
p440 | doi:10.1038/nri2548
The relapsing-remitting form of multiple sclerosis affects around two
thirds of patients with this disease. This Review discusses the roles
of three key molecules - [alpha]4[beta]1 integrin, its binding
partner osteopontin and the chaperone protein [alpha]B crystallin -
in the biology of relapse and remission.
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=2&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
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Focus on: Neuroimmunology
http://links.ealert.nature.com/ctt?kn=89&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Losing your nerves? Maybe it's the antibodies
Betty Diamond, Patricio T. Huerta, Paola Mina�Osorio, Czeslawa Kowal
and Bruce T. Volpe
p449 | doi:10.1038/nri2529
In this Opinion article, Betty Diamond and colleagues propose that
common serum antibodies that crossreact with brain antigens might be
responsible for many acquired changes or congenital impairments in
cognition and behaviour in the absence of overt brain inflammation.
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=33136567&r=MTc2NzU2Mjg3MwS2&b=2&j=NDk5NTUzNjYS1&mt=1&rt=0
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