Signaling Gateway - 1 May 2009
http://links.ealert.nature.com/ctt?kn=37&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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DEVELOPMENT: ABRUPT INHIBITION OF CELL MIGRATION
The protein Abrupt is a point of convergence for the ecdysone and
JAK-STAT pathways during border cell migration in the developing
Drosophila oocyte.
Original research paper: Nature Cell Biology 11, 569-579 (2009)
http://links.ealert.nature.com/ctt?kn=13&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
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Molecule Pages
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NKG2D
http://links.ealert.nature.com/ctt?kn=23&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
NKG2D is a type 2 transmembrane protein with an extracellular C-type
lectin-like domain. Murine NKG2D binds to a set of ligands that have
sequence and structural similarity to class 1 major
histocompatibility complex proteins. Binding of NKG2D to a ligand
triggers a signaling cascade that can promote the cytotoxic
destruction of the cell expressing the ligand for NKG2D by the cell
expressing NKG2D.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=6&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
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Selected Updates
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DNA DAMAGE RESPONSE: HIGHER-ORDER BRCA1 COMPLEXITY
MERIT40 was identified as a novel component of a BRCA1-containing
complex that is required for DNA damage resistance and G2-M
checkpoint control.
Original research paper: Genes Dev. 23, 719-728 (2009)
http://links.ealert.nature.com/ctt?kn=30&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
THERAPEUTICS: TWO FOR ONE
A variant of the monoclonal antibody trastuzumab (Herceptin) can bind
two distinct cancer-related proteins - vascular endothelial growth
factor A (VEGFA) and ERBB2 - and block the growth of breast and colon
cancer cell lines.
Original research paper: Science 323, 1610–1614 (2009)
http://links.ealert.nature.com/ctt?kn=39&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
NEURODEGENERATIVE DISEASE: AMYLOID-BETA AND PRPc: IT TAKES TWO
The cellular prion protein (PrPC) has been implicated in
the pathological actions of amyloid-beta oligomers at neuronal synapses.
Original research paper: Nature 457, 1128-1132 (2009)
http://links.ealert.nature.com/ctt?kn=7&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=31&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
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Research Library
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ORALLY DELIVERED siRNA TARGETING MACROPHAGE MAP4K4 SUPPRESSES
SYSTEMIC INFLAMMATION
Nature 458, 1180–1184 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
WIP1 PHOSPHATASE IS A NEGATIVE REGULATOR OF NF-[kappa]B SIGNALLING
Nature Cell Biology 11, 659–666 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
MOLECULAR DOCKING AND LIGAND SPECIFICITY IN FRAGMENT-BASED INHIBITOR
DISCOVERY
Nature Chemical Biology 5, 358–364 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS IMMUNOLOGY POSTER: ANTIGEN PROCESSING AND PRESENTATION
http://links.ealert.nature.com/ctt?kn=14&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
The process by which antigen-presenting cells digest proteins and
display the resulting antigenic fragments for recognition by T cells
is central to the body's ability to detect infection or abnormal cell
growth. This FREE poster provides an overview of the intracellular
pathways and mechanisms by which antigens are captured, processed and
loaded onto MHC class I, class II and CD1d molecules for presentation
to T cells.
http://links.ealert.nature.com/ctt?kn=27&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
More news
http://links.ealert.nature.com/ctt?kn=29&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
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Gateway Updates
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NATURE PRECEDINGS: PRE-PUBLICATION RESEARCH AND PRELIMINARY FINDINGS
Nature Precedings is a place for researchers to share pre-publication
research and other scientific documents.
http://links.ealert.nature.com/ctt?kn=38&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
Over fifty posters and presentations from the 3rd International
Biocuration Conference in Berlin, Germany are now available on Nature
Precedings.
http://links.ealert.nature.com/ctt?kn=36&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
This collection includes presentations and posters on:
Community curation on WikiPathways
http://links.ealert.nature.com/ctt?kn=15&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
The future of annotation/biocuration
http://links.ealert.nature.com/ctt?kn=3&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
The Eukaryotic Linear Motif (ELM) resource for investigating
candidate short functional motifs in eukaryotic proteins
http://links.ealert.nature.com/ctt?kn=22&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
Search for documents or browse recently posted manuscripts to stay
informed of the latest research in your field.
http://links.ealert.nature.com/ctt?kn=32&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
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Job of the Week
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Research Assistant
Employer: Medical Research Council Laboratory of Molecular Biology
Location: Cambridge, UK
http://links.ealert.nature.com/ctt?kn=12&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
A Research Assistant position is available at the Medical Research
Council Laboratory of Molecular Biology to investigate the
biophysical and structural properties of phosphoinostide 3-kinase
(PI3K)-dependent signaling pathways. Applicants should hold a Masters
degree in a relevant subject area and should have experience with
structural biology and biophysical techniques.
More Jobs:
http://links.ealert.nature.com/ctt?kn=4&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=25&m=32788257&r=MTc2ODc4NDI0MAS2&b=2&j=NDgzMDA0MTcS1&mt=1&rt=0
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