May 2009 Volume 16 Number 5, pp 579 - 706
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Special Issue on Gene Therapy for Chronic Pain
Guest Editors: Joseph Glorioso and David Fink
Volume 16 Number 4
Chronic pain is a significant medical problem. Recent studies suggest that
employing gene transfer to release neuroactive peptides at targeted sites in
the pain pathway may be an effective means to reduce pain, while avoiding
off-target side effects that limit pharmacologic treatment. This issue surveys
results from preclinical animal studies using several different vector
technologies, and describes the first clinical trial of gene transfer for the
treatment of pain using an HSV-based vector that began enrolling patients in
December 2008.
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NEWS AND COMMENTARY
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Innate Immunity confounds the clinical efficacy of small interfering
RNAs (siRNAs)
J J Rossi
http://links.ealert.nature.com/ctt?kn=77&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
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REVIEW
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Progress and prospects: techniques for site-directed mutagenesis in animal
models
Z Yan, X Sun and J F Engelhardt
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
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ORIGINAL ARTICLES
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A 16-bp RBE element mediated Rep-dependent site-specific integration in
AAVS1 transgenic mice for expression of hFIX
Z X Xu, J Z Chen, Y B Yue, J Q Zhang, Z H Li, D M Feng, Z C Ruan, L
Tian, J L Xue, Q J Wang and W Jia
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and
CD8+ T cells for use in the adoptive immunotherapy of cancer
K Birkholz, A Hombach, C Krug, S Reuter, M Kershaw, E Kampgen, G Schuler,
H Abken, N Schaft and J Dorrie
Abstract: http://links.ealert.nature.com/ctt?kn=102&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Validation of a mutated PRE sequence allowing high and sustained transgene
expression while abrogating WHV-X protein synthesis: application to the gene
therapy of WAS
M A Zanta-Boussif, S Charrier, A Brice-Ouzet, S Martin, P Opolon, A J
Thrasher, T J Hope and A Galy
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Rapid [alpha][beta] TCR-mediated responses in [gamma][delta] T cells
transduced with cancer-specific TCR genes
A Hiasa, H Nishikawa, M Hirayama, S Kitano, S Okamoto, H Chono, S S
Yu, J Mineno, Y Tanaka, N Minato, I Kato and H Shiku
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=55&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Eight-year safety follow-up of coronary artery disease patients after
local intracoronary VEGF gene transfer
M Hedman, K Muona, A Hedman, A Kivela, M Syvanne, J Eranen, A Rantala,
J Stjernvall, M S Nieminen, J Hartikainen and S Yla-Herttuala
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=108&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Control by pulse parameters of DNA electrotransfer into solid tumors
in mice
M Cemazar, M Golzio, G Sersa, P Hojman, S Kranjc, S Mesojednik, M-P Rols
and J Teissie
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Intravenous transferrin, RGD peptide and dual-targeted nanoparticles
enhance anti-VEGF intraceptor gene delivery to laser-induced CNV
S R Singh, H E Grossniklaus, S J Kang, H F Edelhauser, B K Ambati and
U B Kompella
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Herpes simplex virus vector-mediated gene delivery of glutamic acid
decarboxylase reduces detrusor overactivity in spinal cord-injured rats
M Miyazato, K Sugaya, W F Goins, D Wolfe, J R Goss, M B Chancellor, W C
de Groat, J C Glorioso and N Yoshimura
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Oncolytic virus therapy for pancreatic cancer using the adenovirus library
displaying random peptides on the fiber knob
T Nishimoto, K Yoshida, Y Miura, A Kobayashi, H Hara, S Ohnami, K Kurisu,
T Yoshida and K Aoki
Abstract: http://links.ealert.nature.com/ctt?kn=69&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Targeting central serotonergic neurons with lentiviral vectors based on a
transcriptional amplification strategy
K Benzekhroufa, B-H Liu, A G Teschemacher and S Kasparov
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Dendritic cells and T cells deliver oncolytic reovirus for tumour killing
despite pre-existing anti-viral immunity
E J Ilett, R J Prestwich, T Kottke, F Errington, J M Thompson, K J
Harrington, H S Pandha, M Coffey, P J Selby, R G Vile and A A Melcher
Abstract: http://links.ealert.nature.com/ctt?kn=99&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
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SHORT COMMUNICATION
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Pseudotyping lentiviral vectors with the wild-type measles virus glycoproteins
improves titer and selectivity
S Funke, I C Schneider, S Glaser, M D Muhlebach, T Moritz, R Cattaneo,
K Cichutek and C J Buchholz
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
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CORRIGENDUM
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Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic
acid-specific, saturable and ion dependent
J Probst, B Weide, B Scheel, B J Pichler, I Hoerr, H-G Rammensee and S Pascolo
http://links.ealert.nature.com/ctt?kn=50&m=32935557&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTUzMzAS1&mt=1&rt=0
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*2007 Journal Citation Report (Thomson Reuters, 2008)
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