April 2009 Volume 16 Number 4, pp 453 - 578
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Special Issue on Gene Therapy for Chronic Pain
Guest Editors: Joseph Glorioso and David Fink
Volume 16 Number 4
Chronic pain is a significant medical problem. Recent studies suggest
that employing gene transfer to release neuroactive peptides at targeted
sites in the pain pathway may be an effective means to reduce pain,
while avoiding off-target side effects that limit pharmacologic
treatment. This issue surveys results from preclinical animal studies
using several different vector technologies, and describes the first
clinical trial of gene transfer for the treatment of pain using an
HSV-based vector that began enrolling patients in December 2008.
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EDITORIAL
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Gene therapy for pain: Introduction to the special issue
J C Glorioso and D J Fink
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
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REVIEWS
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A human trial of HSV-mediated gene transfer for the treatment of chronic
pain
D Wolfe, M Mata and D J Fink
Abstract: http://links.ealert.nature.com/ctt?kn=65&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
AAV for pain: steps towards clinical translation
A S Beutler and M Reinhardt
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Long-term control of neuropathic pain in a non-viral gene therapy paradigm
E M Sloane, R G Soderquist, S F Maier, M J Mahoney, L R Watkins and E D
Milligan
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Lentiviral vectors for gene transfer into the spinal cord glial cells
A Meunier and M Pohl
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Gene therapy for pancreatitis pain
K N Westlund
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
HSV vector-mediated modification of primary nociceptor afferents: an
approach to inhibit chronic pain
J R Goss, M S Gold and J C Glorioso
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Herpes virus-based recombinant herpes vectors: gene therapy for pain
and molecular tool for pain science
D C Yeomans and S P Wilson
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Efficient gene delivery to the adult and fetal CNS using pseudotyped
non-integrating lentiviral vectors
A A Rahim, A M S Wong, S J Howe, S M K Buckley, A D Acosta-Saltos, K
E Elston, N J Ward, N J Philpott, J D Cooper, P N Anderson, S N Waddington,
A J Thrasher and G Raivich
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Cellular tropism and transduction properties of seven adeno-associated
viral vector serotypes in adult retina after intravitreal injection
M Hellstrom, M J Ruitenberg, M A Pollett, E M E Ehlert, J Twisk, J
Verhaagen and A R Harvey
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Gene delivery to human adult and embryonic cell-derived stem cells using
biodegradable nanoparticulate polymeric vectors
F Yang, J J Green, T Dinio, L Keung, S-W Cho, H Park, R Langer and D
G Anderson
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Human adipose tissue-derived mesenchymal stromal cells as vehicles for
tumor bystander effect: a model based on bioluminescence imaging
M Vilalta, I R Degano, J Bago, E Aguilar, S S Gambhir, N Rubio and J
Blanco
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
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SHORT COMMUNICATIONS
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Herpes simplex virus vector-mediated gene delivery for the treatment
of lower urinary tract pain
W F Goins, J R Goss, M B Chancellor, W C de Groat, J C Glorioso and N
Yoshimura
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Reduced proliferation of CD34+ cells from patients with acute myeloid
leukemia after gene transfer of INPP5D
A Metzner, C Precht, B Fehse, W Fiedler, C Stocking, A Gunther, G W
Mayr and M Jucker
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Co-expression of p21Waf1//Cip1 in adenovirus vectors improves expression
of a second transgene
A Schumacher, S Horvat, C Woischwill, G Wolff and C Witt
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=48&m=32933750&r=MTc2MTA1MzIyNwS2&b=2&j=NDk0OTI4MDQS1&mt=1&rt=0
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Nature Reviews Goes Clinical!
In April 2009, Nature Clinical Practice Rheumatology was completely
redesigned and became Nature ReviewsRheumatology, bringing all the
qualities of thetop-ranked* life science review series to the clinical
sciences.
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*2007 Journal Citation Report (Thomson Reuters, 2008)
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