Signaling Gateway - 9 April 2009
http://links.ealert.nature.com/ctt?kn=32&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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PROTEIN KINASE D1: A (SLING)SHOT AGAINST DIRECTED MIGRATION
PKD1 inhibits the activation of cofilin at the cell front via
slingshot phosphatases, thus blocking the formation of free
F-actin barbed ends and directed cell migration.
Original research paper: Nature Cell Biology advance online
publication, 29 March 2009
http://links.ealert.nature.com/ctt?kn=27&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
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Molecule Pages
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Scyl1
http://links.ealert.nature.com/ctt?kn=3&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
Scy1-like 1 (Scyl1) is a member of the Scy1-like family of proteins
that contain highly conserved serine/threonine kinase domains,
although the members of this family seem to be catalytically
inactive. Scyl1 binds coat proteins from clathrin- and COPI-coated
vesicles, suggesting a function in vesicle trafficking. Scyl1 was
identified as the protein mutated in a murine neurodegenerative
disease model, revealing a previously unappreciated link between
COPI trafficking and neurodegeneration.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=25&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
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Selected Updates
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MIGRATION: CALCIUM INFLUX IS MOVING
ORAI1 and STIM1 have a known role in regulating store-operated Ca2+
influx in non-excitable cells, and have now been shown to facilitate
cell migration by regulating focal adhesion turnover.
Original research paper: Cancer Cell. 15, 124-134 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
DEVELOPMENT: LINKING THE LOOPS FOR DIGIT IDENTITY
Researchers have used mathematical modeling to complement genetic
screening in a bid to understand the genetic interactions and
kinetics of feedback loops in mammalian limb development.
Original research paper: Science 323, 1050-1053 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
NEURODEGENERATIVE DISEASE: ORPHAN RECEPTOR COUPLED TO Abeta PRODUCTION
The orphan G-protein-coupled receptor GPR3 has been validated as a
potential new therapeutic target for the treatment of Alzheimer's
disease.
Original research paper: Science 323, 946–951 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=17&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
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Research Library
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TUMOURS WITH PI3K ACTIVATION ARE RESISTANT TO DIETARY RESTRICTION
Nature 458, 725-731 (2009)
http://links.ealert.nature.com/ctt?kn=30&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
p53-COFACTOR JMY IS A MULTIFUNCTIONAL ACTIN NUCLEATION FACTOR
Nature Cell Biology 11, 451-459 (2009)
http://links.ealert.nature.com/ctt?kn=19&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
A FEEDBACK REGULATORY LOOP INVOLVING MICRORNA-9 AND NUCLEAR RECEPTOR
TLX IN NEURAL STEM CELL FATE DETERMINATION
Nature Structural & Molecular Biology 16, 365-371 (2009)
http://links.ealert.nature.com/ctt?kn=10&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS CANCER FOCUS ON MIGRATION AND METASTASIS
http://links.ealert.nature.com/ctt?kn=20&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
Metastasis is the primary cause of mortality in most cancer patients.
The resurgence of interest in this topic has led to significant new
insights and translational developments. The research highlights and
review articles in this Focus on Migration and metastasis describe
our current understanding of this field.
More news
http://links.ealert.nature.com/ctt?kn=23&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
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Gateway Updates
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NATURE PRECEDINGS: PRE-PUBLICATION RESEARCH AND PRELIMINARY FINDINGS
http://links.ealert.nature.com/ctt?kn=34&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
Nature Precedings is a free online service that enables researchers
to openly share preliminary findings, solicit community feedback and
claim priority over discoveries by posting preprint manuscripts,
technical reports, posters and presentations.
Recent preprint manuscripts posted to Nature Precedings include:
Spontaneous development of gastric tumors in mice devoid of
suppressor of cytokine signaling-3 in the gastrointestinal
epithelium
http://links.ealert.nature.com/ctt?kn=12&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
Glucose-6-phosphate-dehydrogenase deficiency as a risk factor in
proliferative disorder development
http://links.ealert.nature.com/ctt?kn=36&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
Search for documents or browse recently posted manuscripts to stay
informed of the latest research in your field.
http://links.ealert.nature.com/ctt?kn=15&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
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Job of the Week
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Research Assistant Professor/Research Associate
Employer: The University of Chicago
Location: Chicago, Illinois, USA
http://links.ealert.nature.com/ctt?kn=8&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
A Senior Cell Biologist position is available in the Department of
Medicine at the University of Chicago. Ongoing studies are focused
on the signaling mechanisms involved in the cytoskeletal regulation
of lung vascular permeability under physiological and pathological
conditions. There is particular interest in understanding the
molecular mechanisms of protein-protein interactions that are
related to the regulation of cellular contacts.
More Jobs:
http://links.ealert.nature.com/ctt?kn=9&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=21&m=32257591&r=MTc2ODc4NDI0MAS2&b=2&j=NDcyNDQxNDYS1&mt=1&rt=0
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