April 9 2009
Visit Nature Reports Stem Cells online.
Now available at http://links.ealert.nature.com/ctt?kn=9&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
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OUR TOP STORIES
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Q&A
John Dick: careful assays for cancer stem cells
The University of Toronto scientist describes how researchers can know what they know
http://links.ealert.nature.com/ctt?kn=26&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Feature
Stem cell research: After Obama's executive order
The US president's executive order does not spell the end to the problems facing ES cell research
http://links.ealert.nature.com/ctt?kn=14&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Related story: New stem cell regulations: By whose authority?
Some think the US should adopt a UK regulatory structure for embryo research
http://links.ealert.nature.com/ctt?kn=7&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Special feature
Neural stem cells: testing gaps between scientific study and biotech product
Overview: Questions you can ask almost any study
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Stem cell-studded scaffolding fills holes left by simulated strokes in rat brains
Bible, E. et al. Biomaterials doi:10.1016/j.biomaterials.2009.02.012 (published online 9 March 2009).
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Human motor neurons engraft in a rat model of Lou Gehrig's disease
Xu, L., Ryugo, D. K., Pongstaporn, T., Johe, K. & Koliatsos, V. E. J. Comp. Neurol. 514, 297-309 (2009).
http://links.ealert.nature.com/ctt?kn=19&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Eight spinal cord injury patients report improvement after surgery that included infusions of their own bone marrow stem cells
Geffner, L. F. et al. Cell Transplant. 17, 1277-1293 (2008).
http://links.ealert.nature.com/ctt?kn=17&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Carbon dating shows humans make new heart cells
The cold war helps settle a hot debate about how hearts grow
Bergmann, O. et al. Science 324, 98-102 (2009)
http://links.ealert.nature.com/ctt?kn=12&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Look now! Human iPS cells with no genetic integration
Six reprogramming factors in a plasmid reach a holy grail
Yu, J. et al. Science doi:10.1126/science.1172482 (published online 26 March 2009).
http://links.ealert.nature.com/ctt?kn=16&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
How tissue-specific stem cells keep their fate
Epidermal stem cells stay skin even if alternative programs aren't suppressed
Ezhkova, E. et al. Cell doi:10.1016/j.cell.2008.12.043 (published online 20 March 2009).
http://links.ealert.nature.com/ctt?kn=23&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Many intestinal villi from a single stem cell, in culture
Even without a supporting niche, intestinal stem cells can self-organize into a mini-organ in a dish
Sato, T. et al. Nature advance online publication, doi:10.1038/nature07935 (29 March 2009).
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G-protein signalling is needed for stem cell homing
G-alpha is vital for engrafting of haematopoeitic stem cells
Adams, G. et al. Nature advance online publication, doi:10.1038/nature07859 (26 March 2009).
http://links.ealert.nature.com/ctt?kn=6&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Noncoding DNA copy number variation links to gene expression in stem cells
A genome-wide study reveals an association between CNVs and gene activity in haematopoietic stem cells
Cahan, P. et al. Nature Genet. advance online publication, doi:10.1038/ng.350 (8 March 2009).
http://links.ealert.nature.com/ctt?kn=10&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
A sort of beta-cell magic: transdetermination seems easier than transdifferentiation
A single added gene prompts liver progenitor cells to make insulin and reverse diabetes
Yechoor, V. et al. Dev. Cell 16, 358-373 (2009)
http://links.ealert.nature.com/ctt?kn=8&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Aberrant as well as embryonic pathways in leukaemic stem cells
Two papers point to how cancer cells go astray
Majeti, R. et al. Proc. Natl Acad. Sci. USA 106, 3396-3401 (2009).
Somervaille, T. C. P. et al. Cell Stem Cell 4, 129-140 (2009).
http://links.ealert.nature.com/ctt?kn=15&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Efficient ES cell differentiation: the right tweak at the right time
Strategies for moving embryonic stem cells toward pancreatic or blood cells
Chen, S. et al. Nature Chem. Biol. advance online publication, doi:10.1038/nchembio.154 (15 March 2009).
Vijayaragavan, K. et al. Cell Stem Cell, 4, 248-262 (2009).
http://links.ealert.nature.com/ctt?kn=2&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
Embryonic stem cells have their own way to deal with viruses
A new zinc finger protein, perhaps the first of many, silences integrated viruses
Wolf, D. & Goff S. Nature advance online publication, doi:10.1038/nature07844 (8 March 2009).
http://links.ealert.nature.com/ctt?kn=13&m=32258339&r=MTc2NjM3NTc5MQS2&b=2&j=NDcyNTA3NDkS1&mt=1&rt=0
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