Signaling Gateway - 3 April 2009
http://links.ealert.nature.com/ctt?kn=32&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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ENERGY HOMEOSTASIS: AMPING UP SIRT1
AMPK responds to energy deprivation by increasing cellular NAD+
levels, which activates SIRT1 and stimulates transcription of genes
important for mitochondrial biogenesis and fatty-acid oxidation.
Original research paper: Nature advance online publication,
4 March 2009
http://links.ealert.nature.com/ctt?kn=24&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
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Molecule Pages
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Heme oxygenase 1
http://links.ealert.nature.com/ctt?kn=3&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
Heme oxygenase-1 (HO-1) is an enzyme originally classified as the
metabolic determinant of heme degradation, which oxidizes heme to
biliverdin, carbon monoxide and free iron. In addition to its
metabolic functions, HO-1 is involved in numerous physiological and
pathophysiologcal processes. HO-1 is the stress response isoform
inducible in all cells by an ever-increasing list of agents,
including heavy metals, oxidative stressors, bacterial endotoxins
and nitric oxide.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=22&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
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Selected Updates
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METASTASIS: CHIPPING AWAY AT TUMOUR PROGRESSION
Reduced levels of the ubiquitin ligase CHIP result in the
accumulation of SRC3, a transcriptional co-activator that controls
the transcription of proteins involved in the epithelial-mesenchymal
transition (EMT).
Original research paper: Nature Cell Biol. 11, 312-319 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
SIGNAL TRANSDUCTION: DELETING PTEN FOR BETTER OR WORSE
Two studies show that PTEN (phosphatase and tensin homolog) and its
downstream signaling pathway might be promising targets for
treatments aimed at boosting neural stem cell proliferation in
neurodegenerative diseases and at reversing the symptoms of some
neurodevelopmental disorders.
Original research paper: J. Neurosci. 29, 1773–1783 (2009)
http://links.ealert.nature.com/ctt?kn=21&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
INNATE IMMUNITY: NOT-SO-LUCKY 7 FOR WEST NILE VIRUS
Brain-resident macrophages detect West Nile virus single-stranded RNA
through Toll-like receptor 7 (TLR7), leading to the secretion of high
levels of interleukin-23 and the attraction of infiltrating
macrophages and other leukocytes that neutralize and clear the
infection.
Original research paper: Immunity 30, 242–253 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=15&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
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Research Library
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FUNCTION OF C/EBPdelta IN A REGULATORY CIRCUIT THAT DISCRIMINATES
BETWEEN TRANSIENT AND PERSISTENT TLR4-INDUCED SIGNALS
Nature Immunology 10, 437-443 (2009)
http://links.ealert.nature.com/ctt?kn=27&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
VALIDATION OF CANDIDATE CAUSAL GENES FOR OBESITY THAT AFFECT SHARED
METABOLIC PATHWAYS AND NETWORKS
Nature Genetics 41, 415-423 (2009)
http://links.ealert.nature.com/ctt?kn=18&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
DISCOVERING CHEMICAL MODIFIERS OF ONCOGENE-REGULATED HEMATOPOIETIC
DIFFERENTIATION
Nature Chemical Biology 5, 236-243 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
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Signaling News
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NATURE INSIGHT: THE UBIQUITIN SYSTEM
http://links.ealert.nature.com/ctt?kn=10&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
The ubiquitin system plays a central role in cell-cycle regulation,
DNA repair, cell growth, signaling and immune function.
Its dysfunction contributes to a range of disorders from cancer to
neurodegeneration. This FREE Nature Insight provides an update to
the most topical themes in ubiquitin research, including reviews on
the origin of the ubiquitin system and cancer therapy that targets
the ubiquitin pathway.
More news
http://links.ealert.nature.com/ctt?kn=20&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
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Gateway Updates
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PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - APRIL UPDATE
http://links.ealert.nature.com/ctt?kn=34&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative for
structural biologists to keep informed of the latest developments
in their field. This month's update features articles on:
The structure of the SARS unique domain
http://links.ealert.nature.com/ctt?kn=31&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
The eIF4A/4G/4H helicase complex
http://links.ealert.nature.com/ctt?kn=9&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
http://links.ealert.nature.com/ctt?kn=26&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
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Job of the Week
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Postdoctoral fellow
Employer: University of Cambridge
Location: Cambridge, United Kingdom
http://links.ealert.nature.com/ctt?kn=8&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
A postdoctoral position is available in the laboratory of
Prof. Dermott Cooper at the University of Cambridge. The successful
applicant will study cyclic AMP compartmentation and Ca2+-sensitive
adenylyl cyclases, and should have prior experience in cell biology
and cell signaling.
More Jobs:
http://links.ealert.nature.com/ctt?kn=11&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=19&m=32247162&r=MTc2ODc4NDI0MAS2&b=2&j=NDcwOTkzMDQS1&mt=1&rt=0
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