April 2009 Volume 6 Number 4
Visit Nature Reviews Gastroenterology & Hepatology online to browse the
journal.
Now available at
http://links.ealert.nature.com/ctt?kn=34&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text access
to Nature Reviews Gastroenterology & Hepatology online. To purchase a
subscription, please visit:
http://links.ealert.nature.com/ctt?kn=45&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=68&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
*********************************************************************
Nature Reviews Gastroenterology & Hepatology Impact Factor: 4.415*
(*Journal Citation Reports, Thomson, 2005)
*********************************************************************
=========================== ADVERTISEMENT ===========================
Nature Clinical Practice Gastroeneterology and Hepatology is now
Nature Reviews Gastroeneterology and Hepatology.
Nature Reviews Gastroeneterology and Hepatology brings the distinguished
reputation of the Nature Reviews series into the clinical sciences. The
journal will remain dedicated to publishing the latest clinical advances
in Gastroeneterology and Hepatology.
For more information visit
http://links.ealert.nature.com/ctt?kn=75&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
=====================================================================
----------------------
EDITORIAL
----------------------
Outsourcing clinical trials
Stephen B. Hanauer
p191 | doi:10.1038/nrgastro.2009.57
http://links.ealert.nature.com/ctt?kn=72&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Dyspepsia: Time to step down?
p193 | doi:10.1038/nrgastro.2009.22
http://links.ealert.nature.com/ctt?kn=26&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Transplantation: Liver-transplantation outcomes poor for IFN-treated
patients with HCV
p194 | doi:10.1038/nrgastro.2009.24
http://links.ealert.nature.com/ctt?kn=91&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Infectious Disease: Diagnosis of C. difficile-associated diarrhea in
immunosuppressed patients
p194 | doi:10.1038/nrgastro.2009.25
http://links.ealert.nature.com/ctt?kn=59&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Hepatitis C: Latino ethnicity influences response to therapy
p195 | doi:10.1038/nrgastro.2009.23
http://links.ealert.nature.com/ctt?kn=22&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Targeted cancer therapy
p195 | doi:10.1038/nrgastro.2009.28
http://links.ealert.nature.com/ctt?kn=79&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Hepatocellular carcinoma: Promising results of dendritic cell-based
immunotherapy
p195 | doi:10.1038/nrgastro.2009.29
http://links.ealert.nature.com/ctt?kn=14&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Nutrition: Obesity increases risk of diverticulitis and diverticular bleeding
p196 | doi:10.1038/nrgastro.2009.26
http://links.ealert.nature.com/ctt?kn=88&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Primary sclerosing cholangitis: Minocycline treatment improves some
biochemical markers of disease
p196 | doi:10.1038/nrgastro.2009.27
http://links.ealert.nature.com/ctt?kn=18&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Infectious disease: A germy world-food-borne infections in 2009
Lawrence R. Schiller
p197 | doi:10.1038/nrgastro.2009.40
The recent outbreak of Salmonella typhimurium, associated with peanut
butter and products containing it in the US and Canada, highlights our
ongoing susceptibility to food-borne infections despite advanced food
production systems. As the globalization of food resources continues,
how can we control outbreaks and minimize their effect on health?
http://links.ealert.nature.com/ctt?kn=39&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Transplantation: Steroid use in HCV-infected liver transplant recipients
Bruno Roche and Didier Samuel
p198 | doi:10.1038/nrgastro.2009.38
The recurrence of hepatitis C in HCV-infected, orthotopic liver transplant
recipients is a major problem that can influence the survival of both
grafted tissue and patients. Yet the effects of immunosuppression
strategies, in particular those of steroids, on disease recurrence remain
unclear.
http://links.ealert.nature.com/ctt?kn=78&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Crohn's disease: Adalimumab improves quality of life
Konstantinos A. Papadakis
p200 | doi:10.1038/nrgastro.2009.39
Antibodies against tumor necrosis factor are a highly effective treatment
for Crohn's disease, as measured by disease-activity indices. But what
influence does this type of therapy have on the health-related quality
of life of patients with Crohn's disease?
http://links.ealert.nature.com/ctt?kn=44&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Colonoscopy: Oral sodium phosphate may worsen kidney dysfunction
Anand Khurana
p201 | doi:10.1038/nrgastro.2009.41
A retrospective, comparative study that focuses on patients with already
impaired kidney function adds to the body of evidence that links
administration of oral sodium phosphate bowel-preparation solutions for
colonoscopy with a decrease in renal function. When possible, a polyethylene
glycol solution should be used instead.
http://links.ealert.nature.com/ctt?kn=74&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Pancreas: A new model to predict mortality in acute pancreatitis
Albert B. Lowenfels and Patrick Maisonneuve
p203 | doi:10.1038/nrgastro.2009.36
A promising new scoring system has stratified mortality risk in a large
group of patients with acute pancreatitis. This new model is more practical
than APACHE II, but needs to be validated in patients in whom the diagnosis
of acute pancreatitis can be verified from detailed clinical records.
http://links.ealert.nature.com/ctt?kn=5&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Celiac disease: Assessment of quality of life
Jolanda M. W. van de Water and Chris J. J. Mulder
p204 | doi:10.1038/nrgastro.2009.37
Adolescents with celiac disease who adhere to a gluten-free diet have a
better quality of life than those who do not comply with the diet, according
to a new study. Adolescents who are diagnosed as having this disease at a
young age also have improved quality of life.
http://links.ealert.nature.com/ctt?kn=53&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
----------------------
REVIEWS
----------------------
A guide to enteral access procedures and enteral nutrition
Stephen J. D. O'Keefe
p207 | doi:10.1038/nrgastro.2009.20
This review discusses advances in enteral access procedures that have
considerably broadened the indications for tube feeding and have led to
a substantial reduction in the need for total parenteral nutrition. Enteral
feeding can now be given to most patients in the intensive care, and is
associated with improved outcomes.
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Mechanisms of HCV survival in the host
Ella H. Sklan, Prista Charuworn, Philip S. Pang and Jeffrey S. Glenn
p217 | doi:10.1038/nrgastro.2009.32
HCV infection is a key cause of liver disease and a worldwide health
problem. The authors of this Review discuss the HCV life cycle and the
mechanisms that enable the virus to evade host immune mechanisms and persist
within the host. Improved understanding of HCV survival strategies should
facilitate the development of effective antiviral therapies.
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=2&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Intestinal fibrosis in IBD-a dynamic, multifactorial process
Florian Rieder and Claudio Fiocchi
p228 | doi:10.1038/nrgastro.2009.31
Intestinal fibrosis is a common and potentially serious complication of IBD.
The traditional view that the development of fibrosis in these patients is
inevitable and irreversible is progressively changing with improved
understanding of the pathogenic mechanisms of fibrosis. This Review discusses
the complex general mechanisms of fibrosis and addresses specific issues
related to intestinal fibrosis in the setting of IBD, including the potential
implications of novel treatments.
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Endocrine and liver interaction: the role of endocrine pathways in NASH
Paola Loria, Lucia Carulli, Marco Bertolotti and Amedeo Lonardo
p236 | doi:10.1038/nrgastro.2009.33
Several endocrine disorders are thought to have a role in the etiology of
chronic liver disease and the development of nonalcoholic steatohepatitis.
This Review discusses the evidence that causally links hormonal disorders,
including thyroid disorders, growth hormone and adrenal insufficiency and
polycystic ovary syndrome with liver disease. The role of hormone replacement
to normalize liver function in some patients is also discussed.
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
----------------------
CASE STUDY
----------------------
A case of biliopleural fistula in a patient with hepatocellular carcinoma
Jeffrey R. Lewis, Helen S. Te, Brian Gehlbach, Aytekin Oto, Jennifer Chennat
and Smruti R. Mohanty
p248 | doi:10.1038/nrgastro.2009.34
This article considers the case of a 66-year-old white man who presented
with a productive cough and pleuritic chest pain on his right side 6
months after undergoing transarterial chemoembolization for hepatocellular
carcinoma. The patient was diagnosed with a biliopleural fistula, and this
Case Study explores the diagnosis and management of this patient.
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
SUBMIT TODAY to the #1 clinical journal covering gastroenterology
& hepatology: The American Journal of Gastroenterology (AJG). New features
include a new look, more color for charts and graphs, a newly designed
website, early online publication, and much more. Check out the author
benefits today!
Visit http://links.ealert.nature.com/ctt?kn=57&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
to learn more.
=====================================================================
You have been sent this Table of Contents Alert because you have opted
in to receive it. You can change or discontinue your e-mail alerts at
any time, by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=25&m=32247053&r=MTc2OTYyOTQ2MwS2&b=2&j=NDcwOTgxNDkS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
