Signaling Gateway - 17 April 2009
http://links.ealert.nature.com/ctt?kn=32&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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NEURAL DEVELOPMENT: PROTEOGLYCANS GO FORTH TO MULTIPLY
Sonic hedgehog requires interactions with proteoglycans to achieve
cell proliferation, but not tissue patterning.
Original research paper: Nature Neuroscience 12, 409-417 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
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Selected Updates
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PLANT CELL BIOLOGY: WHEN AUTUMN FALLS
Age-dependent senescence in Arabidopsis thaliana leaves is regulated
by three components of a feed-forward loop — ORESARA 1 (ORE1),
ETHYLENE INSENSITIVE 2 (EIN2) and the microRNA miR164.
Original research paper: Science 323, 1053-1057 (2009)
http://links.ealert.nature.com/ctt?kn=3&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
DEVELOPMENT AND DISEASE: ALZHEIMER'S PROTEIN IN EMBRYONIC PRUNING
Embryonic neuronal connections are refined by amyloid precursor
protein (APP) signaling through the death receptor DR6, which may
also have a role in the development of Alzheimer's disease.
Original research paper: Nature 457, 981–989 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
MUSCULAR DYSTROPHY: FIXING THE LEAK
A defect in the skeletal muscle ryanodine receptor (RYR1) may
contribute to the deregulated Ca2+ homeostasis and muscle
damage typical of Duchenne muscular dystrophy (DMD), suggesting that
it could be a new therapeutic target for this disease.
Original research paper: Nature Med. 15, 325-330 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=23&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
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Research Library
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STAT3 INHIBITION OF GLUCONEOGENESIS IS DOWNREGULATED BY SIRT1
Nature Cell Biology 11, 492-500 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
STIMULATION OF TUMOR GROWTH AND ANGIOGENESIS BY LOW CONCENTRATIONS
OF RGD-MIMETIC INTEGRIN INHIBITORS
Nature Medicine 15, 392-400 (2009)
http://links.ealert.nature.com/ctt?kn=20&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
ANALYSIS OF THE EUKARYOTIC PRENYLOME BY ISOPRENOID AFFINITY TAGGING
Nature Chemical Biology 5, 227-235 (2009)
http://links.ealert.nature.com/ctt?kn=29&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
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Signaling News
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NATURE IMMUNOLOGY FOCUS ON IMMUNE SIGNALING CROSS-TALK
http://links.ealert.nature.com/ctt?kn=21&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
Nature Immunology presents a Focus issue on the complex interplay
between the signaling pathways that operate within immune cells.
These Focus pieces were specially commissioned with the intention of
bolstering the concept that many influential immune cell signaling
pathways actually engage in complex, often bidirectional,
cross-talk with heterologous pathways.
More news
http://links.ealert.nature.com/ctt?kn=14&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - APRIL UPDATE
http://links.ealert.nature.com/ctt?kn=9&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
This month's update features:
Polo-like kinase signaling events in the cell cycle
http://links.ealert.nature.com/ctt?kn=30&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
E-cadherin signaling in keratinocytes
http://links.ealert.nature.com/ctt?kn=13&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
An introduction to the PANTHER Pathway resource
http://links.ealert.nature.com/ctt?kn=11&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
Sign up here to receive the monthly update alert for the NCI-Nature
Pathway Interaction Database.
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Job of the Week
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Faculty Positions in Mitochondrial Biology and Cell Metabolism
Employer: University of Washington
Location: Washington, Seattle, USA
http://links.ealert.nature.com/ctt?kn=8&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
The Mitochondria and Metabolism Center at the University of
Washington School of Medicine seeks to fill multiple faculty
positions at the level of Assistant or Associate Professor.
Applications will be considered in all areas of mitochondria and
metabolism research, including biology and genetics of mitochondria,
signaling mechanisms, systems biology and translational research.
More Jobs:
http://links.ealert.nature.com/ctt?kn=10&m=32273912&r=MTc2ODc4NDI0MAS2&b=2&j=NDc0MzAzMzQS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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