May 2009 Volume 10 Number 5
Visit Nature Reviews Molecular Cell Biology online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=10&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text access
to Nature Reviews Molecular Cell Biology online. To purchase a subscription,
please visit: http://links.ealert.nature.com/ctt?kn=44&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=64&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
*********************************************************************
Nature Reviews Molecular Cell Biology Impact Factor: 31.921*
(*Journal Citation Reports, Thomson, 2008)
*********************************************************************
=========================== ADVERTISEMENT ===========================
IT'S NOW FREE TO POST YOUR VACANCY ON
naturejobs.com
http://links.ealert.nature.com/ctt?kn=59&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
It's the breakthrough you've been waiting for. Naturejobs.com - the
scientific jobs board from Nature now lets you advertise your vacancy
completely FREE OF CHARGE
Go to http://links.ealert.nature.com/ctt?kn=38&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0 or telephone:
Europe: +44 (0) 20 78434961
US: + 1 800 9897718
=========================== ADVERTISEMENT ===========================
Nature Reviews Microbiology and Nature Cell Biology
Focus on Microbial Host Cell Subversion
To highlight advances in our understanding of the mechanisms by which
microorganisms tailor cellular pathways to their own needs, Nature Reviews
Microbiology and Nature Cell Biology present a set of specially commissioned
articles that focus on some of the key pathways in host cells that are
subverted by microorganisms during infection or colonization.
To access the articles from this Focus and the accompanying library,
visit http://links.ealert.nature.com/ctt?kn=46&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
=====================================================================
=====================================================================
This month's FEATURED article:
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream
signalling pathways
Brenda A. Schulman and J. Wade Harper
p319 | doi:10.1038/nrm2673
http://links.ealert.nature.com/ctt?kn=90&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
=====================================================================
From the editors
p299 | doi:10.1038/nrm2687
http://links.ealert.nature.com/ctt?kn=87&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
DNA damage response: Higher-order BRCA1 complexity
p301 | doi:10.1038/nrm2683
http://links.ealert.nature.com/ctt?kn=68&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Small RNAs: MicroRNAs get a boost
p302 | doi:10.1038/nrm2670
http://links.ealert.nature.com/ctt?kn=24&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Autophagy: Breaking and exiting
p302 | doi:10.1038/nrm2671
http://links.ealert.nature.com/ctt?kn=93&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Membrane trafficking: Earliest endosomes
p302 | doi:10.1038/nrm2676
http://links.ealert.nature.com/ctt?kn=56&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
IN BRIEF
Autophagy | Prions | RNA decay | Cell division
p303 | doi:10.1038/nrm2684
http://links.ealert.nature.com/ctt?kn=1&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Cytoskeleton: JMY: actin up in cell motility
p304 | doi:10.1038/nrm2678
http://links.ealert.nature.com/ctt?kn=81&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Epigenetics: A silent inheritance
p304 | doi:10.1038/nrm2682
http://links.ealert.nature.com/ctt?kn=91&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
DNA damage response: Change of guard at the checkpoint
p305 | doi:10.1038/nrm2677
http://links.ealert.nature.com/ctt?kn=27&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
STRUCTURE WATCH
Cyclin D-CDK4 finds form | Structural checkpoint
p305 | doi:10.1038/nrm2681
http://links.ealert.nature.com/ctt?kn=71&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
JOURNAL CLUB
A new ubiquitin chain, a new signal
p306 | doi:10.1038/nrm2685
http://links.ealert.nature.com/ctt?kn=26&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Technology: Structure provides clues
p306 | doi:10.1038/nrm2686
http://links.ealert.nature.com/ctt?kn=60&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
----------------------
REVIEWS
----------------------
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma and John Blenis
p307 | doi:10.1038/nrm2672
Cells have evolved complex mechanisms to control overall protein
synthesis and the translation of specific mRNAs. At the heart of
this process is the mammalian target of rapamycin (mTOR) signalling
pathway, which senses and responds to nutrient availability, energy
sufficiency, stress, hormones and mitogens to modulate protein synthesis.
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream
signalling pathways
Brenda A. Schulman and J. Wade Harper
p319 | doi:10.1038/nrm2673
The attachment of ubiquitin-like proteins (UBLs) to proteins is a
central mechanism of modulation of protein function. Enzymatic,
structural and genetic studies have elucidated how mechanistically
and structurally related E1 enzymes activate UBLs and selectively
direct them to downstream pathways.
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=90&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
The trip of the tip: understanding the growth cone machinery
Laura Anne Lowery and David Van Vactor
p332 | doi:10.1038/nrm2679
The journey of the growth cone is similar to a vehicle on a road.
Cytoskeletal elements form the 'motor' to move forward and provide
traction on the road, whereas a 'navigator' system guides the vehicle
to translate environmental signals into directional movement.
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Ion channels versus ion pumps: the principal difference, in principle
David C. Gadsby
p344 | doi:10.1038/nrm2668
Ions move across cell membranes through either ion channels or ion pumps.
Recently, atomic-resolution structures and high-resolution functional
measurements of examples from both channels and pumps have begun to
suggest that these molecules need not be as different as was once thought.
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
----------------------
PERSPECTIVES
----------------------
OPINION
Bringing up the rear: defining the roles of the uropod
Francisco Sanchez-Madrid and Juan M. Serrador
p353 | doi:10.1038/nrm2680
The uropod, a protrusion at the rear of amoeboid motile cells such as
leukocytes, exemplifies the importance of morphology in cell motility.
Although the signalling and structural requirements of uropod formation
are being characterized, a clear understanding of uropod function is
still lacking.
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
OPINION
The evolving understanding of COPI vesicle formation
Victor W. Hsu, Stella Y. Lee and Jia-Shu Yang
p360 | doi:10.1038/nrm2663
Coat proteins, such as coat protein I (COPI), couple vesicle formation
with cargo sorting to ensure the generation of correctly packaged
transport vesicles. Emerging evidence suggests that some long-held
views on how COPI vesicles are formed need to be revised.
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Corrigendum: Polo-like kinases: conservation and divergence in their
functions and regulation
Vincent Archambault and David M. Glover
p364 | doi:10.1038/nrm2675
http://links.ealert.nature.com/ctt?kn=13&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Nature Insight The Ubiquitin System
This Insight covers the most topical themes in cellular roles of the
ubiquitin system and highlights how an understanding of this system might
contribute to the development of novel therapies.
Access the Insight FREE online for 6 months
http://links.ealert.nature.com/ctt?kn=9&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
Produced with support from
Hybrigenics, ITI Life Sciences and Scil Proteins GmbH
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=28&m=32423489&r=MTc2NzYzNjQ2NgS2&b=2&j=NDc3Mjk3MzkS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
