9 April 2009 Volume 458 Number 7239, pp 679 - 796
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FREE ARTICLE
Antibiotics and inhibition of fatty acid biosynthesis
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The importance of fatty acid biosynthesis to bacterial
survival has made the pathway fertile ground for antibiotic
targets, and at least three companies are pursuing compounds
that block the process. French researchers, however, have
challenged the approach with a paper in Nature that describes
how Gram-positive bacteria can assimilate host fatty acids
to ensure bacterial survival. What was the reaction of companies
developing inhibitors of the pathway?
Find out more by reading the first in-depth analysis of
the scientific and commercial potential of the work in
SciBX: Science-Business eXchange.
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EDITORIALS
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Early warnings p679
Screening programmes for cancer detection are not always as
effective at saving lives as might be hoped. Improving the
situation will require a concerted effort on a broad front.
doi:10.1038/458679a
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Tough climate pp679-680
The US National Academy of Sciences faces a difficult balancing act
over global warming.
doi:10.1038/458679b
http://links.ealert.nature.com/ctt?kn=161&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Welcome, Nature Chemistry p680
doi:10.1038/458680a
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RESEARCH HIGHLIGHTS
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Evolution: Flights of fancy p682
doi:10.1038/458682a
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Ecology: Equality in dirt p682
doi:10.1038/458682b
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Quantum dots: Pillars progress p682
doi:10.1038/458682c
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Atmospheric science: Bolt from the storm p682
doi:10.1038/458682d
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Astronomy: Slow and steady p682
doi:10.1038/458682e
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Biophysics: DNA made for walking pp682-683
doi:10.1038/458682f
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Immunology: Inflaming the problem p683
doi:10.1038/458683a
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Development: The trouble with alcohol p683
doi:10.1038/458683b
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Chemistry: Three in one p683
doi:10.1038/458683c
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Geology: Flooding on the Silk Road p683
doi:10.1038/458683d
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JOURNAL CLUB
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Journal club p683
Michael Heckenberger
doi:10.1038/458683e
http://links.ealert.nature.com/ctt?kn=144&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
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NEWS
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Obama's nuclear-weapons-free vision pp684-685
President extends US commitment to arms reduction.
Declan Butler
doi:10.1038/458684a
http://links.ealert.nature.com/ctt?kn=197&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Korean satellite misses orbit p685
Third time unlucky as payload plunges into the Pacific.
Geoff Brumfiel
doi:10.1038/458685a
http://links.ealert.nature.com/ctt?kn=63&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Cutting off cancer's supply lines pp686-687
Targeting the blood vessels that feed tumours is not the silver
bullet once hoped for, but refinements to the strategy may suggest
further ways to treat the disease. Erika Check Hayden reports.
doi:10.1038/458686b
http://links.ealert.nature.com/ctt?kn=71&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Volcanoes ignite monitoring efforts p689
Efforts intensify after eruptions in Alaska and Chile.
Rex Dalton
doi:10.1038/458689b
http://links.ealert.nature.com/ctt?kn=119&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Open-access policy flourishes at NIH pp690-691
Researchers, institutions and publishers have complied with the
mandate, but it still has its opponents.
Meredith Wadman
doi:10.1038/458690a
http://links.ealert.nature.com/ctt?kn=58&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Snapshot: Gapping the bridge p690
Radar image reveals damage to ice shelf.
Quirin Schiermeier
doi:10.1038/458690b
http://links.ealert.nature.com/ctt?kn=86&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Sagging economy clips clean tech's wings p692
doi:10.1038/458692a
http://links.ealert.nature.com/ctt?kn=113&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Europe revises animal-research proposals p692
doi:10.1038/458692b
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Skeleton transfer to Native Americans put on hold p692
doi:10.1038/458692c
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Italian laboratory escapes quake damage p693
doi:10.1038/458693a
http://links.ealert.nature.com/ctt?kn=77&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
US AIDS programme 'essential and expensive' p693
doi:10.1038/458693b
http://links.ealert.nature.com/ctt?kn=49&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Costs for airborne telescope spiral upwards p693
doi:10.1038/458693c
http://links.ealert.nature.com/ctt?kn=11&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
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NEWS FEATURES
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Evolution: Biology's next top model? pp695-698
From Antarctic icefish to Galapagos finches, there are some
interesting characters at the fringes of developmental biology.
Brendan Maher explores a world of alternative model organisms.
doi:10.1038/458695a
http://links.ealert.nature.com/ctt?kn=207&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Greek research: Feast and famine pp700-701
While researchers in Greece starve for government support,
biomedicine is thriving at a lavish new centre in Athens, finds
Alison Abbott.
doi:10.1038/458700a
http://links.ealert.nature.com/ctt?kn=139&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
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CORRESPONDENCE
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Let's not reignite an unproductive controversy p702
John Dupre and Paul E. Griffiths
doi:10.1038/458702a
http://links.ealert.nature.com/ctt?kn=223&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
What does applying 'scientific values' mean in reality? p702
Mike Hulme
doi:10.1038/458702b
http://links.ealert.nature.com/ctt?kn=233&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Dialogue between the disciplines is thriving p702
Giovanni Frazzetto
doi:10.1038/458702c
http://links.ealert.nature.com/ctt?kn=104&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Widen the channels of communication with society p702
Stephen Curry
doi:10.1038/458702d
http://links.ealert.nature.com/ctt?kn=245&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
For anyone who ever said there's no such thing as a poetic gene p703
Claes Gustafsson
doi:10.1038/458703a
http://links.ealert.nature.com/ctt?kn=140&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Brain technologies raise unprecedented ethical challenges p703
Olaf Blanke and Jane E. Aspell
doi:10.1038/458703b
http://links.ealert.nature.com/ctt?kn=83&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
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BOOKS AND ARTS
----------------------
A clash of visual cultures pp704-705
Nick Hopwood applauds an account of how US scientists used images to
counter creationism and promote public understanding of evolution in
the 1920s.
Nick Hopwood reviews God - or Gorilla: Images of Evolution in
the Jazz Age by Constance Areson Clark
doi:10.1038/458704a
http://links.ealert.nature.com/ctt?kn=241&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Drawing from Darwin p705
Carl Zimmer reviews Endless Forms: Charles Darwin, Natural Science
and the Visual Arts.
doi:10.1038/458705a
http://links.ealert.nature.com/ctt?kn=167&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Shaking the tree of life p706
Ronald Jenner reviews Perspectives in Animal Phylogeny and Evolution.
doi:10.1038/458706a
http://links.ealert.nature.com/ctt?kn=266&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Q&A: The molecular master chef p707
Twenty-five years ago this week, food writer Harold McGee published
a Nature paper on the science of whipping egg whites in copper bowls.
Here he explains how he first developed an interest in science and
cooking.
Daniel Cressey
doi:10.1038/458707a
http://links.ealert.nature.com/ctt?kn=196&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Corrections p707
doi:10.1038/458707b
http://links.ealert.nature.com/ctt?kn=174&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
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NEWS AND VIEWS
----------------------
Drug discovery: Fresh target for cancer therapy pp709-710
The Byzantine system for degrading proteins inside cells is already
the target of a successful anticancer drug. A compound that inhibits
another part of this system also shows promise in models of cancer
in mice.
Raymond J. Deshaies
doi:10.1038/458709a
http://links.ealert.nature.com/ctt?kn=38&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Astrophysics: Hidden Universe uncovered pp710-711
An experiment flying on a balloon at the edge of the atmosphere
offers the deepest far-infrared view of the sky yet achieved,
revealing previously unidentified, dust-obscured, star-forming
galaxies in the early Universe.
Ian Smail
doi:10.1038/458710a
http://links.ealert.nature.com/ctt?kn=143&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Cancer: When restriction is good pp713-714
Dietary restriction can prolong life and delay the onset of cancer.
Suppressing the signalling pathway that is mediated by the hormone
insulin might be crucial for the anticancer effects of reduced
caloric intake.
Anne Brunet
doi:10.1038/458713a
http://links.ealert.nature.com/ctt?kn=120&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Biogeochemistry: Less nickel for more oxygen pp714-715
The availability (or lack) of oceanic trace elements is providing
fresh lines of explanation for turning points in Earth's history
- the Great Oxidation Event being one such momentous occasion.
Mak A. Saito
doi:10.1038/458714a
http://links.ealert.nature.com/ctt?kn=249&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Stem cells: Low-risk reprogramming pp715-716
New techniques circumvent a roadblock to the production of
embryonicstem-cell-like lines from adult tissue. Such reprogrammed
cell lines should be much safer to use for therapy.
Martin F. Pera
doi:10.1038/458715a
http://links.ealert.nature.com/ctt?kn=132&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
50 & 100 years ago p716
doi:10.1038/458716a
http://links.ealert.nature.com/ctt?kn=9&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Physical chemistry: How to improve your image pp716-717
The technique of second harmonic generation microscopy is used to
obtain pictures of living systems, but the dyes required provide
only modest imaging contrast per molecule. The latest dyes give a
much better picture.
Michael J. Therien
doi:10.1038/458716b
http://links.ealert.nature.com/ctt?kn=251&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Obituary: Hidesaburo Hanafusa (1929-2009) p718
Inspiration and innovation in molecular cancer research.
David A. Foster and James E. Darnell Jr
doi:10.1038/458718a
http://links.ealert.nature.com/ctt?kn=43&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
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REVIEW
----------------------
The cancer genome pp719-724
Michael R. Stratton, Peter J. Campbell and P. Andrew Futreal
doi:10.1038/nature07943
Abstract: http://links.ealert.nature.com/ctt?kn=209&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=189&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
----------------------
ARTICLES
----------------------
Tumours with PI3K activation are resistant to dietary restriction
pp725-731
The authors show that mouse or human tumours in which the PI3K/Akt
pathway is constitutively activated are resistant to dietary
restriction whereas other tumours are sensitive. The authors also
implicate the Akt target gene FOXO1 in the response to dietary
restriction.
Nada Y. Kalaany and David M. Sabatini
doi:10.1038/nature07782
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=208&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
An inhibitor of NEDD8-activating enzyme as a new approach to treat
cancer pp732-736
This study has developed the first small molecule NEDD8-activating
enzyme (NAE) inhibitor, which induces cancer cell death and exerts
anti-tumour activity in preclinical mouse models. This work
establishes NAE as an anti-cancer target and may lead to new
anti-cancer therapeutics.
Teresa A. Soucy et al.
doi:10.1038/nature07884
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
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Nature Collections Cancer
This week, Nature updates the Nature Collection on
Cancer with a series of research papers and review
material on some of the recent advances in cancer research.
Access selected content from the updated collection
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Produced with support from Boehringer Ingelheim GmbH,
Asterand, Cephalon, Genentech, and Biogen Idec
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LETTERS
----------------------
Over half of the far-infrared background light comes from galaxies
at z [ge] 1.2 pp737-739
Submillimetre surveys have discovered a population of luminous,
high-redshift, dusty starburst galaxies, which go through a phase
of very rapid star formation, resulting in approximately equal
extragalactic optical and far infrared backgrounds (FIRB). Devlin
et al. report an extragalactic survey at 250, 350 and 500 [micro]m;
they determine that all of the FIRB comes from individual galaxies,
with galaxies at redshift z [ge] 1.2 accounting for 70 per cent of
it.
Mark J. Devlin et al.
doi:10.1038/nature07918
Abstract: http://links.ealert.nature.com/ctt?kn=130&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Interdimensional universality of dynamic interfaces pp740-742
Despite the complexity and diversity of nature, universality exists
in the form of critical scaling laws for dissimilar systems such as
stock markets, lung inflation and earthquakes. This universality
seems to depend only on the symmetry and dimension of the system.
Kab-Jin Kim and co-authors demonstrate that in ferromagnetic
nanowires, the magnetic domain wall dynamics are universal even
when the system changes from two dimensional to one.
Kab-Jin Kim et al.
doi:10.1038/nature07874
Abstract: http://links.ealert.nature.com/ctt?kn=126&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=227&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Enhancement of the Nernst effect by stripe order in a high-Tc
superconductor pp743-745
The Nernst effect in metals is sensitive to superconductivity and
density-wave order. The large positive Nernst signal observed in
hole-doped high-transition-temperature superconductors has been
attributed to fluctuating superconductivity but Olivier
Cyr-Choiniere and colleagues report that the Nernst signal can be
caused by stripe order. In LSCO doped with Nd or Eu, the onset of
stripe order causes the Nernst signal to go from small and negative
to large and positive.
Olivier Cyr-Choiniere et al.
doi:10.1038/nature07931
Abstract: http://links.ealert.nature.com/ctt?kn=267&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Low-temperature oxidation of CO catalysed by Co3O4 nanorods pp746-749
Tricobalt tetraoxide (Co3O4) is a potential catalyst for
low-temperature oxidation of carbon monoxide (required in automotive
emission control) but although it is active even at subzero
temperatures, it is highly sensitive to moisture. By forming Co3O4
into nanorods, Xiaowei Xie and colleagues make it more active and
also stable in the presence of water; they attribute these
improvements to the high density of catalytically active Co3+ sites
exposed on the nanorod surface.
Xiaowei Xie et al.
doi:10.1038/nature07877
Abstract: http://links.ealert.nature.com/ctt?kn=135&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Oceanic nickel depletion and a methanogen famine before the Great
Oxidation Event pp750-753
A decrease in atmospheric methane levels might have triggered the
progressive rise of atmospheric oxygen about 2.4 billion years ago,
but the cause of this methane decrease remains uncertain. Kurt
Konhauser and colleagues report a decline in the oceanic
nickel-to-iron ratio about 2.7 billion years ago, which they
attribute to a reduced flux of nickel to the oceans; this decline
would have stifled the activity of methane-producing organisms that
require nickel to function.
Kurt O. Konhauser et al.
doi:10.1038/nature07858
Abstract: http://links.ealert.nature.com/ctt?kn=255&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=220&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Phylogenetic biome conservatism on a global scale pp754-756
How constrained is the ecology of a species by its phylogenetic
history? The authors assess the extent of biome conservatism - the
tendency of a species to occupy the same niche as its ancestors - in
over 11,000 Southern Hemisphere plants, 15% of the total flora of
the Southern Hemisphere continents. They show that only 3.6% of the
evolutionary divergences in their study involved a shift of biome,
demonstrating the strong influence of biome conservatism.
Michael D. Crisp et al.
doi:10.1038/nature07764
Abstract: http://links.ealert.nature.com/ctt?kn=166&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=204&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Role of Jhdm2a in regulating metabolic gene expression and obesity
resistance pp757-761
The histone demethylase Jhdm2a (also known as Kdm3a) has an important
role in nuclear hormone receptor-mediated gene activation and male
germ cell development. Here the authors disrupt the Jhdm2a gene in
mice to demonstrate that Jhdm2a also regulates expression of
metabolic genes such as Ppara and Ucp1; the obese phenotype of the
knockout mice indicates the demethylase is involved in regulation
of weight control.
Keisuke Tateishi, Yuki Okada, Eric M. Kallin and Yi Zhang
doi:10.1038/nature07777
Abstract: http://links.ealert.nature.com/ctt?kn=111&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=218&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase
expression and glutamine metabolism pp762-765
This paper shows that c-Myc regulates the microRNAs miR-23a and
miR-23b to increase the expression of the mitochondrial enzyme
glutaminase. This leads to enhanced glutamine metabolism and
contributes to the metabolic changes in c-Myc-driven cancers.
Ping Gao et al.
doi:10.1038/nature07823
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
piggyBac transposition reprograms fibroblasts to induced pluripotent
stem cells pp766-770
This paper uses the piggyBac transposon to generate stable iPS cells
from human and mouse fibroblasts; the individual piggyBac insertions
can then be removed from established iPS cell lines. The study also
demonstrates removal of reprogramming factors joined with
2A sequences (described in an accompanying paper;
doi:10.1038/nature07864) delivered by a single transposon from
murine iPS lines.
Knut Woltjen et al.
doi:10.1038/nature07863
Abstract: http://links.ealert.nature.com/ctt?kn=183&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=191&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Virus-free induction of pluripotency and subsequent excision of
reprogramming factors pp771-775
This paper presents a technique to reprogram mouse and human
fibroblasts to induce pluripotency. The authors show that the
transgene can be removed once reprogramming has been achieved with
a piggyBac transposon (described in an accompanying paper;
doi:10.1038/nature07863). This system minimizes genome modification
in induced pluripotent stem cells and enables complete elimination
of exogenous reprogramming factors.
Keisuke Kaji et al.
doi:10.1038/nature07864
Abstract: http://links.ealert.nature.com/ctt?kn=257&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Hedgehog signalling is essential for maintenance of cancer stem
cells in myeloid leukaemia
Here it is shown that Hedgehog signalling is important in chronic
myeloid leukaemia (CML), where it acts to maintain leukaemia stem
cells by regulating the expression of Numb. CML stem cells can be
depleted when Hedgehog signalling is inhibited, including cells
that are resistant to the drug imatinib that is used to treat CML.
Chen Zhao et al.
doi:10.1038/nature07737
Abstract: http://links.ealert.nature.com/ctt?kn=164&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=164&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Association of reactive oxygen species levels and radioresistance
in cancer stem cells
This study shows that cancer stem cell in breast tumours have lower
levels of reactive oxygen species (ROS) than the rest of the tumour
cells. This property renders cancer stem cells less sensitive to
radiation therapy, which may cause radioresistance in breast cancer.
Maximilian Diehn et al.
doi:10.1038/nature07733
Abstract: http://links.ealert.nature.com/ctt?kn=225&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=225&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Structure and function of the 5'[rarr]3' exoribonuclease
Rat1 and its activating partner Rai1 pp784-788
This study reports the structures of two complexes: Rat1-Rai1 and
Dom3Z (the mouse Rat1 homologue)-Rai1. These structures reveal the
mechanism of exonuclease activity and define the catalytic
differences with another class of nucleases containing a PIN domain.
The work also reveals that Rai1 has pyrophosphohydrolase activity,
the first such activity found in eukaryotes.
Song Xiang et al.
doi:10.1038/nature07731
Abstract: http://links.ealert.nature.com/ctt?kn=114&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=138&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
--------------------------------------------------------------------------------
NATUREJOBS
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News
Early intervention p791
Awards allow young scientists to pursue risky research.
Karen Kaplan
doi:10.1038/nj7239-791a
http://links.ealert.nature.com/ctt?kn=229&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Postdoc journal
Kidding around p791
Bryan Venters
doi:10.1038/nj7239-791b
http://links.ealert.nature.com/ctt?kn=264&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
In Brief
Vietnam pay complaints p791
Vietnamese science struggles.
doi:10.1038/nj7239-791c
http://links.ealert.nature.com/ctt?kn=222&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Bioscience park launched p791
Research park planned in Minnesota.
doi:10.1038/nj7239-791d
http://links.ealert.nature.com/ctt?kn=210&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
BP Solar cuts 620 jobs p791
Solar power firm downsizing.
doi:10.1038/nj7239-791e
http://links.ealert.nature.com/ctt?kn=165&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Careers and Recruitment
Prevention by numbers p792
Researchers who study environmental influences on cancer tend to
receive a fraction of the funds available to those researching
cancer cures. But career opportunities exist — and may even be
expanding. Heidi Ledford reports.
doi:10.1038/nj7239-792a
http://links.ealert.nature.com/ctt?kn=59&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Manifesto p796
The sin of self.
Joao Ramalho-Santos
doi:10.1038/458796a
http://links.ealert.nature.com/ctt?kn=169&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
08 April 2009
Discovery of dual function acridones as a new antimalarial chemotype
Jane X. Kelly et al.
doi:10.1038/nature07937
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair
pathway throughout the cell cycle
Maximina H. Yun and Kevin Hiom
doi:10.1038/nature07955
Abstract: http://links.ealert.nature.com/ctt?kn=184&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=184&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
06 April 2009
A hub-and-spoke circuit drives pheromone attraction and social
behaviour in C. elegans
Evan Z. Macosko et al.
doi:10.1038/nature07886
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Snowdrift game dynamics and facultative cheating in yeast
Jeff Gore, Hyun Youk and Alexander van Oudenaarden
doi:10.1038/nature07921
Abstract: http://links.ealert.nature.com/ctt?kn=248&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=248&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Genetic analysis of radiation-induced changes in human gene
expression
Denis A. Smirnov et al.
doi:10.1038/nature07940
Abstract: http://links.ealert.nature.com/ctt?kn=105&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=105&m=32255668&r=MjA1NTkxMDA2MAS2&b=2&j=NDcyMTUwMDUS1&mt=1&rt=0
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