Stem Cells for Multiple Sclerosis: Part 2

View this message online Hello manoj kumar valluru, Last week an interesting news story about >20 Texan patients treated with stem cells suffering from multiple sclerosis came out.  We watch these developments with cautious optimism. Click here for the video. A recent paper describing TNF-alpha inhibiting SDF-1 secretion was published.  This may explain some of the osteoclastic effects seen in patients with chronic inflammation.  Another interesting finding was that EPO can inhibit the mouse model of multiple sclerosis through stimulation of Treg and inhibition of Th17.  Maybe this is why some cancer patients do worse if they are on chronic EPO? Two neat patents came out last week.  #7,494,644 covers the transfection of cells (myoblasts and mesenchymal) with connexin-43 to increase their ability to interact with myocardium.  This could be a great way of overcoming arrythmias seen with some myoblast-based approaches.  Irv Weissman continues his patent domination of the field of hematology, getting a patent on the megakaryocytic progenitor (#7,494,807).  He is inventor on the common myeloid progenitor, as well as common lymphoid progenitor patents.  Great job Irv ! Although the majority of studies looking at stem cell mediated immune modulation have been focused on mesenchymal stem cells, a recent paper describes suppression of the mouse model of MS through administration of hematopoietic stem cells, and demonstrated that therapeutic effect was associated with upregulation of indolamine 2,3 deoxygenase in the dendritic cells.    Methods and compositions for correction of cardiac conduction disturbances     Patent Number: 7,494,644 Assignee | Inventor It is known that bone marrow stem cells are mobilized after heart injury such as infarct, with presumable therapeutic effects mediated by the stem cells in terms of stimulating angiogenesis or even integrating into the damaged myocardium and transdifferentiating into de novo [Read More] Ask a question OR leave your comments.     Stem Cell Therapy for Multiple Sclerosis Monday March 2nd, 2009 @ 20:41:36 EST The use of stem cells for treatment of multiple sclerosis has the potential to address both the inflammatory aspects of the disease, as well as induce regeneration.  Below is a clip from a news release describing what appears to be a repeatedly successful treatment of multiple...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News   Media Partnerships (NEW)   PATENTS - WHAT'S GETTING ATTENTION?     Methods for altering cell fate to generate T-cells specific for... | 1 Comment(s)     NEWS - WHAT'S GETTING ATTENTION?     Bone Marrow Stem Cells for Renal Failure | 11 Comment(s)     Interferon gamma as a "danger signal" | 2 Comment(s)     RECENTLY ADDED PATENTS     Mammalian megakaryocyte progenitor cell (7,494,807) Assignee | Inventor | Ask a question OR leave your comments     Methods and compositions for correction of cardiac conduction disturbances (7,494,644) Assignee | Inventor | Ask a question OR leave your comments     Methods for altering cell fate to generate T-cells specific for an antigen of interest (7,491,534) Assignee | Inventor | 1 Comment     Uses of fibroblasts or supernatants from fibroblasts for the suppression of immune responses in transplantation (7,491,388) Assignee | Inventor | Ask a question OR leave your comments     Use of glycosylceramides as adjuvants for vaccines against infections and cancer (7,488,491) Assignee | Inventor | Ask a question OR leave your comments     Wound and cutaneous injury healing with a nucleic acid encoding perlecan (7,488,719) Assignee | Inventor | Ask a question OR leave your comments     PSCA: prostate stem cell antigen and uses thereof in pancreatic cancer (7,485,296) Assignee | Inventor | Ask a question OR leave your comments     Enhanced growth of adult stem cells with Dkk-1 (7,485,460) Assignee | Inventor | Ask a question OR leave your comments     Biomaterial derived from vertebrate liver tissue (7,482,025) Assignee | Inventor | Ask a question OR leave your comments     Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats (7,482,332) Assignee | Inventor | Ask a question OR leave your comments     View all 1392 Stem Cell Patents on StemCellPatents.com     LATEST NEWS     Stem Cell Therapy for Multiple Sclerosis 2 hours ago     TNF alpha inhibits SDF-1 increases osteoclast precursors 21 hours ago     EPO Protects from Mouse Multiple Sclerosis 4 days ago     Stem Cell Inhibition of Multiple Sclerosis by IDO Induction February 22nd     Resistance to Fas Induced Apoptosis in Glioma Stem Cells February 13th     Read more news on StemCellPatents.com     LATEST JOBS POSTS     View the StemCellPatents.com Job Board   Thanks again for your help in supporting StemCellPatents.com. 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