19 March 2009 Volume 458 Number 7236, pp 259-376
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EDITORIALS
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Turkey censors evolution p259
Turkey's government has done more for science than many. A row over
a censored magazine and a sacked editor could put the good work at risk.
doi:10.1038/458259a
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Health highway pp259-260
President Obama's funds for electronic health records should prompt
research -- and controversy.
doi:10.1038/458259b
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Filling the void p260
As science journalism declines, scientists must rise up and reach out.
doi:10.1038/458260a
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RESEARCH HIGHLIGHTS
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Planetary science: Fiery fountains p262
doi:10.1038/458262a
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Evolution: Painful pairing p262
doi:10.1038/458262b
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Chemistry: Buckyball expansion p262
doi:10.1038/458262c
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Cancer therapeutics: Socking it to melanoma p262
doi:10.1038/458262d
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Genomics: Staying in shape p262
doi:10.1038/458262e
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Sexual selection: Cheap flights pp262-263
doi:10.1038/458262f
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Genomics: Big is beautiful p263
doi:10.1038/458263a
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Molecular imaging: Nailing the molecule p263
doi:10.1038/458263b
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Evolution: Fishy fangs p263
doi:10.1038/458263c
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Materials: Five-star ice p263
doi:10.1038/458263d
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Correction p263
doi:10.1038/458263e
http://links.ealert.nature.com/ctt?kn=142&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
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JOURNAL CLUB
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Journal club p263
Ahmad M. Khalil
doi:10.1038/458263f
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NEWS
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Europe's green billions pp264-265
Clean-energy investments target eastern Europe, but it remains to be
seen whether they will create as many new jobs as hoped.
Quirin Schiermeier
doi:10.1038/458264a
http://links.ealert.nature.com/ctt?kn=13&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Society sues journal over right to reply pp264-265
Row between Max Planck Society and Wiley escalates.
Alison Abbott
doi:10.1038/458264b
http://links.ealert.nature.com/ctt?kn=66&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Scientists in bone battle p265
Native American lay claim to 10,000-year-old skeletons.
Rex Dalton
doi:10.1038/458265a
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America's long hard road to climate-change law pp266-267
What challenges lie ahead as the United States tries to construct a
working system for greenhouse-gas regulation? Jeff Tollefson reports.
Jeff Tollefson
doi:10.1038/458266a
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Big interest in heavy drugs p269
The drug industry is seeking profits by modifying hydrogen in
existing medications.
Katharine Sanderson
doi:10.1038/458269a
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Roche vows to keep Genentech culture p270
It will be business as usual despite merger, say bosses.
Erika Check Hayden
doi:10.1038/458270a
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Incoming chief to tackle woes of US food and drug agency p271
Obama nominates Margaret 'Peggy' Hamburg as FDA chief.
Meredith Wadman
doi:10.1038/458271a
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Yale climate-change institute launched p272
doi:10.1038/458272a
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NIH research to become permanently open access p272
doi:10.1038/458272b
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Maths mistake blamed for killing off 'clean coal' plant pp272-273
doi:10.1038/458272c
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Soundbites from Copenhagen p272
Views from the International Scientific Congress on Climate
Change, 10-12 March.
doi:10.1038/458272d
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Lighter Higgs boson harder to find p273
doi:10.1038/458273a
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Hospital investigation reveals long-running fraud p273
doi:10.1038/458273b
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NEWS FEATURES
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Science journalism: Supplanting the old media? pp274-277
Science journalism is in decline; science blogging is growing fast.
But can the one replace the other, asks Geoff Brumfiel.
doi:10.1038/458274a
http://links.ealert.nature.com/ctt?kn=138&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Clinical epidemiology: Archived answers pp278-280
The switch to electronic medical records opens up a potential wealth
of data for researchers, if major obstacles can be overcome, reports
Katharine Gammon.
doi:10.1038/458278a
http://links.ealert.nature.com/ctt?kn=253&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
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CORRESPONDENCE
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Diversity of funding sources and topics is key to survival p281
Brian Derby
doi:10.1038/458281a
http://links.ealert.nature.com/ctt?kn=229&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Grant-writing offices would let scientists get on with research p281
Cecile Perrault
doi:10.1038/458281b
http://links.ealert.nature.com/ctt?kn=104&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
We need more insight into what's worth paying for p281
William Gunn
doi:10.1038/458281c
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Backlogged system in Australia shuts out new investigators p281
Darren Saunders
doi:10.1038/458281d
http://links.ealert.nature.com/ctt?kn=139&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
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ESSAY
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Do nations go to war over water? pp282-283
Wendy Barnaby was asked to write a book about water wars -- then
the facts got in the way of her story.
Wendy Barnaby
doi:10.1038/458282a
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BOOKS AND ARTS
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When wise words are not enough pp284-285
Thomas Homer-Dixon argues that opinion-makers must demonstrate a
better grasp of how societies rise and fall if they are to steer
nations successfully through many of this century's major crises.
Thomas Homer-Dixon reviews Global Catastrophes and Trends: The Next
Fifty Years by Vaclav Smil
doi:10.1038/458284a
http://links.ealert.nature.com/ctt?kn=238&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Universe in a box pp285-286
Pedro Ferreira reviews Joseph Cornell and Astronomy: A Case for the
Stars by Kirsten Hoving
doi:10.1038/458285a
http://links.ealert.nature.com/ctt?kn=161&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
A romp through science fiction p286
Stefano Tonzani reviews Nanovision: Engineering the Future by Colin
Milburn
doi:10.1038/458286a
http://links.ealert.nature.com/ctt?kn=263&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Disturbing the Arkansas river p287
Laura Spinney reviews Over The River, A Work in Progress
doi:10.1038/458287a
http://links.ealert.nature.com/ctt?kn=195&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Not one to watch p287
Michael White reviews Watchmen
doi:10.1038/458287b
http://links.ealert.nature.com/ctt?kn=172&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
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NEWS AND VIEWS
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Spectroscopy: Handedness in quick time pp289-290
The handedness of chiral molecules can be probed spectroscopically,
but acquiring data can take hours, which is a problem for
time-resolved studies. The latest method records such data in a flash.
Patrick H. Vaccaro
doi:10.1038/458289a
http://links.ealert.nature.com/ctt?kn=44&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Cancer: The nuances of therapy pp290-292
Lee M. Ellis and David A. Reardon
doi:10.1038/458290a
http://links.ealert.nature.com/ctt?kn=141&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
50 & 100 years ago p291
doi:10.1038/458291a
http://links.ealert.nature.com/ctt?kn=57&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Geophysics: Hot blanket in Earth's deep crust pp292-293
Studies of rocks from Earth's crust suggest that the lower crust is
a good thermal insulator. The knock-on effects of this finding are
many -- one being the crust's increased potential to generate more
magma.
Jean Braun
doi:10.1038/458292a
http://links.ealert.nature.com/ctt?kn=237&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Dinosaurs: Fuzzy origins for feathers pp293-295
Cretaceous fossil deposits in China are famous for their feathered
dinosaurs. But the surprising discovery of a herbivorous dinosaur
with a filamentous coat raises fresh questions about the evolution
of feathers.
Lawrence M. Witmer
doi:10.1038/458293a
http://links.ealert.nature.com/ctt?kn=96&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Chemistry: Thinking outside the flask p294
Stephen Davey
doi:10.1038/458294a
http://links.ealert.nature.com/ctt?kn=235&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Global change: West-side story of Antarctic ice pp295-296
During the past five million years, the West Antarctic ice sheet has
waxed and waned in size. A two-pronged reconstruction of that history
provides clues to the ice sheet's future behaviour.
Philippe Huybrechts
doi:10.1038/458295a
http://links.ealert.nature.com/ctt?kn=12&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Neuroscience: Secret of synapse specificity pp296-297
How does the brain organize all of the information stored in memory?
On the basis of a state-of-the-art imaging study of neuronal activity
in real time, the answer seems to be, through specificity in space
and time.
Scott M. Thompson and Hayley A. Mattison
doi:10.1038/458296a
http://links.ealert.nature.com/ctt?kn=136&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
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BRIEF COMMUNICATIONS ARISING
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Hippopotamus and whale phylogeny ppE1-E4
Jonathan H. Geisler and Jessica M. Theodor
doi:10.1038/nature07776
Abstract: http://links.ealert.nature.com/ctt?kn=270&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=188&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Thewissen et al. reply pE5
J. G. M. Thewissen et al.
doi:10.1038/nature07775
Abstract: http://links.ealert.nature.com/ctt?kn=140&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=257&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
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ARTICLES
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Activation of CaMKII in single dendritic spines during long-term
potentiation pp299-304
This study has developed a new imaging technology to track the
activation of CaMKII locally within an individual dendritic spine.
CaMKII is transiently activated during synaptic potentiation and
does not spread to neighbouring dendritic domains, thus ensuring
that synaptic changes remain localized.
Seok-Jin R. Lee, Yasmin Escobedo-Lozoya, Erzsebet M. Szatmari and
Ryohei Yasuda
doi:10.1038/nature07842
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=193&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Design and engineering of an O2 transport protein pp305-309
The authors used de novo protein design to generate a simple unnatural
oxygen transport protein, akin to human neuroglobin; the design
strategy involved the assembly of a short helix-forming sequence into
a four-helix bundle that contained histidine residues at key positions.
The O2 on-rate, off-rate and dissociation constants are similar to
those of human neuroglobin and other naturally occurring globins.
Ronald L. Koder et al.
doi:10.1038/nature07841
Abstract: http://links.ealert.nature.com/ctt?kn=163&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=265&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
In April 2009 Nature Clinical Practice Rheumatology
will become Nature Reviews Rheumatology, with a new
look and additional content.
For more information visit:
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LETTERS
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Femtosecond characterization of vibrational optical activity of chiral
molecules pp310-313
Circular dichroism spectroscopy can determine optical activity in a
time-resolved manner, raising the exciting prospect of directly
mapping structural changes of important chemical or biological
processes involving chiral molecules. Rhee et al. have overcome
experimental difficulties to show that optical activity in the
infrared can be detected with femtosecond time-resolution by
heterodyned spectral interferometry, setting the stage for making
'molecular motion pictures' of fundamental processes from a chiral
perspective.
Hanju Rhee et al.
doi:10.1038/nature07846
Abstract: http://links.ealert.nature.com/ctt?kn=122&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=222&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Hybrid organic-inorganic rotaxanes and molecular shuttles pp314-318
Rotaxanes, in which ring-shaped subunits encircle the 'axles' of
molecular dumb-bells, have been mooted as possible components of
molecular machines. To date, most rotaxanes are organic, but David
Leigh and colleagues now report hybrid rotaxanes, which are
expected to offer a far wider range of useful physical properties
to molecular engineers than purely organic rotaxanes.
Chin-Fa Lee et al.
doi:10.1038/nature07847
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=247&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Temperature-dependent thermal diffusivity of the Earth's crust and
implications for magmatism pp319-321
The thermal evolution of planetary crust and lithosphere is governed
by the rate of heat transfer by conduction, which is determined by
the rock's thermal diffusivity, usually assumed to remain constant.
Alan Whittington and colleagues show that thermal diffusivity in fact
decreases strongly with increasing temperature, concluding that the
hot middle and lower crust is a much more effective thermal insulator
than previously thought; this removes the requirement for unusually
high radiogenic heat production to achieve crustal melting temperatures.
Alan G. Whittington, Anne M. Hofmeister and Peter I. Nabelek
doi:10.1038/nature07818
Abstract: http://links.ealert.nature.com/ctt?kn=65&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Obliquity-paced Pliocene West Antarctic ice sheet oscillations pp322-328
The response of the vast West Antarctic Ice Sheet (WAIS) to climate
shifts due to changes in Earth's orbit is uncertain, but there is
potential for several metres of sea level change. Naish and co-authors
extracted a sediment core from beneath the Ross Ice Shelf and found
evidence that the WAIS periodically collapsed during the early
Pliocene (3-5 million years ago); and the pattern of collapse suggests
an influence of ~40,000-year cycles in the tilt of Earth's rotational axis.
T. Naish et al.
doi:10.1038/nature07867
Abstract: http://links.ealert.nature.com/ctt?kn=69&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=159&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Modelling West Antarctic ice sheet growth and collapse through the
past five million years pp329-332
If the West Antarctic Ice Sheet (WAIS) melted, sea levels would rise
by about 5 m; such changes are thought to have occurred in the past
but could not be simulated by models. Pollard and DeConto combine
ice-sheet with ice-shelf modelling, and show that over the past 5
million years, the WAIS transitioned among full, intermediate, and
collapsed states in only a few thousand years, suggesting possible
disintegration of the WAIS if ocean temperatures in the area rise
by 5 [deg]C.
David Pollard and Robert M. DeConto
doi:10.1038/nature07809
Abstract: http://links.ealert.nature.com/ctt?kn=216&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=230&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
An Early Cretaceous heterodontosaurid dinosaur with filamentous
integumentary structures pp333-336
All the dinosaurs with feathers or similar integumentary structures
have been theropods, and such feathery appurtenances have been absent
among the distantly related ornithischian dinosaurs, with the possible
exception of Psittacosaurus. In this paper the authors describe an
ornithischian, belonging to a group of primitive ornithischian
dinosaurs called heterodontosaurs, that has an all-over covering of
feather-like structures, much more like those seen in theropods.
Xiao-Ting Zheng, Hai-Lu You, Xing Xu and Zhi-Ming Dong
doi:10.1038/nature07856
Abstract: http://links.ealert.nature.com/ctt?kn=200&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Population genomics of domestic and wild yeasts pp337-341
By sequencing over seventy isolates of the domesticated baker's yeast
Saccharomyces cerevisiae and its closest relative, S. paradoxus, this
study describes variation in gene content, SNPs, indels, copy numbers
and transposable elements, providing insights into the evolution of
different lineages, phenotypic variation, domestication and population
structure of Saccharomyces.
Gianni Liti et al.
doi:10.1038/nature07743
Abstract: http://links.ealert.nature.com/ctt?kn=213&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=214&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Comprehensive polymorphism survey elucidates population structure of
Saccharomyces cerevisiae pp342-345
This study provides a nucleotide-level survey of genome variation in
63 Saccharomyces cerevisiae strains sampled from different ecological
niches and geographical locations. The analysis of genome-wide patterns
of the nucleotide polymorphism and deletion variants discovered lays
the foundation for genome-wide association studies in yeast.
Joseph Schacherer, Joshua A. Shapiro, Douglas M. Ruderfer and
Leonid Kruglyak
doi:10.1038/nature07670
Abstract: http://links.ealert.nature.com/ctt?kn=184&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Antiviral immunity in Drosophila requires systemic RNA interference
spread pp346-350
RNA silencing is an important player in antiviral defence mechanisms.
This paper provides evidence that RNA silencing possesses a systemic
arm not only in plants but also in insects; systemic spread of dsRNA
from cell to cell is an important component of the antiviral immune
response in Drosophila.
Maria-Carla Saleh et al.
doi:10.1038/nature07712
Abstract: http://links.ealert.nature.com/ctt?kn=202&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=211&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Regulatory T-cell suppressor program co-opts transcription factor
IRF4 to control TH2 responses pp351-356
This paper shows that regulatory T (Treg) cells express the
transcription factor IRF4, which is essential for the differentiation
of TH2 effector cells. IRF4 depletion in Treg cells induces
TH2-driven autoimmune disease, leading the authors to suggest that
IRF4 directs a module within Treg cells that selectively suppresses
TH2 responses.
Ye Zheng et al.
doi:10.1038/nature07674
Abstract: http://links.ealert.nature.com/ctt?kn=150&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Defensin-like polypeptide LUREs are pollen tube attractants secreted
from synergid cells pp357-361
In this study, Higashiyama and colleagues examine pollen tube guidance
in Torenia fournieri and identify the secreted guidance factors. These
are cysteine-rich polypeptides belonging to the subgroup of
defensin-like proteins (designated as LUREs), which are predominantly
expressed in synergid cells and are required for pollen tube guidance.
Satohiro Okuda et al.
doi:10.1038/nature07882
Abstract: http://links.ealert.nature.com/ctt?kn=160&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
The DNA-encoded nucleosome organization of a eukaryotic genome
pp362-366
This study tests the importance of the intrinsic DNA sequence
preferences of nucleosomes by measuring the genome-wide occupancy of
nucleosomes assembled on purified yeast genomic DNA. The resulting
map is similar to in vivo nucleosome maps, indicating that the
organization of nucleosomes in vivo is largely governed by the
underlying genomic DNA sequence.
Noam Kaplan et al.
doi:10.1038/nature07667
Abstract: http://links.ealert.nature.com/ctt?kn=220&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=55&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Transmembrane passage of hydrophobic compounds through a protein
channel wall pp367-370
In this paper Hearn et al. present the structure of an Escherichia
coli long-chain fatty acid importer, FadL, which reveals an opening
in the wall of its transmembrane beta-barrel. They further show that
a mutant in which this opening is constricted is unable to transport
substrate, and conclude that importers, like exporters, may exploit
lateral diffusion for the transport of hydrophobic substrates.
Elizabeth M. Hearn et al.
doi:10.1038/nature07678
Abstract: http://links.ealert.nature.com/ctt?kn=137&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=179&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Prospects
Stem cell recruits p371
Lifting the stem-cell ban has repercussions that go beyond science
ethics and disease cures.
Gene Russo
doi:10.1038/nj7236-371a
http://links.ealert.nature.com/ctt?kn=225&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Special Report
Personnel dilemma p372
The hiring of US science faculty members has slowed considerably.
Karen Kaplan tracks the administrators who are trying to keep
programmes intact.
Karen Kaplan
doi:10.1038/nj7236-372a
http://links.ealert.nature.com/ctt?kn=50&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Career View
Louise Ryan, chief, mathematical and information sciences,
Commonwealth Scientific and Industrial Research Organisation,
Sydney, Australia p374
Biostatistician seeks to boost statistics research posts in
Australia.
Virginia Gewin
doi:10.1038/nj7236-374a
http://links.ealert.nature.com/ctt?kn=100&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
A bill to care for carers p374
Congresswoman seeks legislation to provide grant extensions for
federally funded scientists who need extended family leave.
Heidi Ledford
doi:10.1038/nj7236-374b
http://links.ealert.nature.com/ctt?kn=178&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
As simple as possible p374
Is my marketability more important than my curiosity?
Sam Walcott
doi:10.1038/nj7236-374c
http://links.ealert.nature.com/ctt?kn=41&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Takeaway p376
A word to the wise.
Tony Ballantyne
doi:10.1038/458376a
http://links.ealert.nature.com/ctt?kn=227&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
18 March 2009
Histone modifications at human enhancers reflect global
cell-type-specific gene expression
Nathaniel D. Heintzman et al.
doi:10.1038/nature07829
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=146&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Directional Delta and Notch trafficking in Sara endosomes during
asymmetric cell division
F. Coumailleau, M. Furthauer, J. A. Knoblich and M. Gonzalez-Gaitan
doi:10.1038/nature07854
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Temporally precise in vivo control of intracellular signalling
Raag D. Airan et al.
doi:10.1038/nature07926
Abstract: http://links.ealert.nature.com/ctt?kn=128&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=262&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
15 March 2009
Gene regulatory logic of dopamine neuron differentiation
Nuria Flames and Oliver Hobert
doi:10.1038/nature07929
Abstract: http://links.ealert.nature.com/ctt?kn=123&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=260&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Broad diversity of neutralizing antibodies isolated from memory B
cells in HIV-infected individuals
Johannes F. Scheid et al.
doi:10.1038/nature07930
Abstract: http://links.ealert.nature.com/ctt?kn=264&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=233&m=32044198&r=MjA1NTkxMDA2MAS2&b=2&j=NDY2MjQzMjUS1&mt=1&rt=0
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