Stem Cell Therapy of MS Requires IDO

View this message online Hello manoj kumar valluru, Although the majority of studies looking at stem cell mediated immune modulation have been focused on mesenchymal stem cells, a recent paper describes suppression of the mouse model of MS through administration of hematopoietic stem cells, and demonstrated that therapeutic effect was associated with upregulation of indolamine 2,3 deoxygenase in the dendritic cells.  Osiris continues to advance its patent portfolio, last week being issued patent # 7,491,388, which covers the use of fibroblasts for prevention of graft versus host disease.  A stunning example of creativity was patent #7,491,534 which teaches how to generate T cells from fibroblasts !! and as if that was not enough, teaches how to select the T cells for specific T cell receptors so that they may be used in immunotherapy.  Very Very Interesting !   Uses of fibroblasts or supernatants from fibroblasts for the suppression of immune responses in transplantation     Patent Number: 7,491,388 Assignee | Inventor We know that mesenchymal stem cells are immune modulatory through a variety of means such as secretion of HLA-G, expression of indolamine 2,3 deoxygenase, and production of immune suppressive cytokines.  What is relatively understudied is the immune...[Read More] Ask a question OR leave your comments.     Stem Cell Inhibition of Multiple Sclerosis by IDO Induction Sunday February 22nd, 2009 @ 23:52:52 EST Lodz, Poland - Video on bottom of page !  One of the very interesting things is trying to figure out how stem cells mediate their therapeutic effects in conditions such as multiple sclerosis.  In general there are three main ways: 1) Differentiation into neurons/oligodendrocytes; 2) [Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News   Media Partnerships (NEW)   RECENTLY ADDED PATENTS     Methods for altering cell fate to generate T-cells specific for an antigen of interest (7,491,534) Assignee | Inventor | Ask a question OR leave your comments     Uses of fibroblasts or supernatants from fibroblasts for the suppression of immune responses in transplantation (7,491,388) Assignee | Inventor | Ask a question OR leave your comments     Use of glycosylceramides as adjuvants for vaccines against infections and cancer (7,488,491) Assignee | Inventor | Ask a question OR leave your comments     Wound and cutaneous injury healing with a nucleic acid encoding perlecan (7,488,719) Assignee | Inventor | Ask a question OR leave your comments     PSCA: prostate stem cell antigen and uses thereof in pancreatic cancer (7,485,296) Assignee | Inventor | Ask a question OR leave your comments     Enhanced growth of adult stem cells with Dkk-1 (7,485,460) Assignee | Inventor | Ask a question OR leave your comments     Biomaterial derived from vertebrate liver tissue (7,482,025) Assignee | Inventor | Ask a question OR leave your comments     Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats (7,482,332) Assignee | Inventor | Ask a question OR leave your comments     Method of enhancing myogenesis by electrical stimulation (7,483,749) Assignee | Inventor | Ask a question OR leave your comments     In vivo assay and molecular markers for testing the phenotypic stability of cell populations and selected cell populations for autologous transplantation (7,479,367) Assignee | Inventor | Ask a question OR leave your comments     View all 1390 Stem Cell Patents on StemCellPatents.com     LATEST NEWS     Stem Cell Inhibition of Multiple Sclerosis by IDO Induction 14 hours ago     Resistance to Fas Induced Apoptosis in Glioma Stem Cells February 13th     Mesenchymal Stem Cells Inhibit Gamma Delta T Cell Proliferation February 10th     Endometrial Regenerative Cells Inhibit Glioma February 8th : 1 Comment     Periodontal Ligament Mesenchymals are Immune Suppressive February 1st     Read more news on StemCellPatents.com     LATEST JOBS POSTS     View the StemCellPatents.com Job Board   Thanks again for your help in supporting StemCellPatents.com. Media Partnerships (NEW) (BETA) ------------------------------------------------------------ To unsubscribe, click here. Delivered: Monday February 23rd, 2009 @ 14:15:26 EST