March 2009 Volume 10 Number 3
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This month's FEATURED article:
Epigenetic inheritance during the cell cycle
Aline V. Probst, Elaine Dunleavy and Genevieve Almouzni
p192 | doi:10.1038/nrm2640
http://links.ealert.nature.com/ctt?kn=35&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
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From the editors
p157 | doi:10.1038/nrm2649
http://links.ealert.nature.com/ctt?kn=4&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Development: Deciphering the Wingless gradient
p159 | doi:10.1038/nrm2644
http://links.ealert.nature.com/ctt?kn=58&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Cell cycle: Signalling to wait
p160 | doi:10.1038/nrm2643
http://links.ealert.nature.com/ctt?kn=42&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Membrane dynamics: Clamping complexin
p160 | doi:10.1038/nrm2650
http://links.ealert.nature.com/ctt?kn=51&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
IN BRIEF
Telomeres | DNA-damage response | Ageing | microRNA
p161 | doi:10.1038/nrm2647
http://links.ealert.nature.com/ctt?kn=22&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Cell signalling: NEMO keeps it straight
p162 | doi:10.1038/nrm2638
http://links.ealert.nature.com/ctt?kn=66&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
TECHNOLOGY WATCH
Take your PICh | SUMO goes global
p162 | doi:10.1038/nrm2648
http://links.ealert.nature.com/ctt?kn=2&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Mechanotransduction: Switch and stretch
p163 | doi:10.1038/nrm2642
http://links.ealert.nature.com/ctt?kn=46&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
JOURNAL CLUB
Blebbing: motility research moves in a new direction
p164 | doi:10.1038/nrm2604
http://links.ealert.nature.com/ctt?kn=20&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Cytoskeleton: The making of a filament
p164 | doi:10.1038/nrm2635
http://links.ealert.nature.com/ctt?kn=16&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
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REVIEWS
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Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
Hellmut G. Augustin, Gou Young Koh, Gavin Thurston and Kari Alitalo
p165 | doi:10.1038/nrm2639
Tie receptors and their angiopoietin ligands have important functions
during embryonic vessel assembly and maturation, and control adult vascular
homeostasis. The structural characteristics and the spatio-temporal
regulation of these receptors and ligands provide important insights
into their functions.
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Orchestrating nuclear envelope disassembly and reassembly during mitosis
Stephan Guttinger, Eva Laurell and Ulrike Kutay
p178 | doi:10.1038/nrm2641
The nuclear envelope is a dynamic structure that is disassembled and
reassembled during 'open' mitosis in higher eukaryotes. These mitotic
changes are subject to both spatial and temporal control mechanisms
that are embedded in the more general regulatory network that directs
cell division.
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Article series: Chromatin dynamics
http://links.ealert.nature.com/ctt?kn=39&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Epigenetic inheritance during the cell cycle
Aline V. Probst, Elaine Dunleavy and Genevieve Almouzni
p192 | doi:10.1038/nrm2640
Epigenetic inheritance concerns the mechanisms that ensure the transmission
of epigenetic marks from mother to daughter cell. Chromatin modifications
and nuclear organization are candidate epigenetic marks - whether they
fulfil the criterion of heritability and what mechanisms ensure their
propagation is an area of intensive research.
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Article series: Stem cells
http://links.ealert.nature.com/ctt?kn=70&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Epidermal homeostasis: a balancing act of stem cells in the skin
Cedric Blanpain and Elaine Fuchs
p207 | doi:10.1038/nrm2636
The proper establishment of the skin barrier during embryogenesis and
its maintenance during adult homeostasis is crucial for survival.
Interestingly, the molecular mechanisms that govern embryonic development
of the epidermis are reused during adult life to regulate skin homeostasis.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
ABC transporters: the power to change
Douglas C. Rees, Eric Johnson and Oded Lewinson
p218 | doi:10.1038/nrm2646
ATP-binding cassette (ABC) transporters are responsible for the
ATP-powered translocation of many substrates across membranes.
Structural similarities support a common mechanism by which ABC
transporters, both importers and exporters, couple the binding and
hydrolysis of ATP to substrate translocation.
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
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PERSPECTIVE
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OPINION
Single proteins might have dual but related functions in intracellular
and extracellular microenvironments
Derek C. Radisky, Melody Stallings-Mann, Yohei Hirai and Mina J. Bissell
p228 | doi:10.1038/nrm2633
Maintenance of organ homeostasis and control of appropriate responses to
environmental alterations requires the coordination of cellular functions
and tissue organization. This coordination could be achieved by proteins
that can have distinct but linked functions on both sides of the plasma membrane.
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
Erratum: Mechanisms of regulated unconventional protein secretion
Walter Nickel and Catherine Rabouille
p234 | doi:10.1038/nrm2645
http://links.ealert.nature.com/ctt?kn=32&m=31609032&r=MTc2NzYzNjQ2NgS2&b=2&j=NDYwMDgzNTYS1&mt=1&rt=0
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