Signaling Gateway - 20 February 2009
http://links.ealert.nature.com/ctt?kn=33&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
STRUCTURAL BIOLOGY: DEATH CLUSTERS
The structure of the Fas-FADD death domain complex reveals how it
switches on apoptosis solely through oligomerization and clustering.
Original research paper: Nature 457, 1019-1022 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
------------------------
Molecule Pages
------------------------
RIP140
http://links.ealert.nature.com/ctt?kn=3&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
Receptor interacting protein 140 (RIP140) is a transcriptional
co-regulator of many nuclear receptors and several transcription
factors. Studies of RIP140 knockout animals and various cell-culture
models demonstrate the function of RIP140 in a wide variety of
biological processes, such as metabolism, cell proliferation and
carcinogenesis. RIP140 represses target gene expression in most
experimental systems examined; it acts in a ligand-dependent manner
for nuclear receptors and, therefore, belongs to the ligand-dependent
co-repressor category.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=24&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
-------------------
Selected Updates
-------------------
MECHANISMS OF DISEASE: HOW STRESS AFFECTS FAT
Cellular stress induced by a high-fat diet activates JNK1 in
adipocytes, which contributes to the development of hepatic insulin
resistance by increasing interleukin 6 expression.
Original research paper: Science 322, 1539–1543 (2008)
http://links.ealert.nature.com/ctt?kn=34&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
ONCOGENE REPRESSION: CDYL AND REST - A SILENT TEAM
A trimeric CDYL-G9a-REST complex suppresses expression of the
neurotrophic tyrosine kinase receptor type 3 (NTRK3, also known as
TRKC) and prevents cellular transformation.
Original research paper: Mol. Cell 32, 718–726 (2008)
http://links.ealert.nature.com/ctt?kn=23&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
MICROSCOPY: IMAGING GOES LABEL-FREE
A new technology based on stimulated Raman scattering allows
three-dimensional imaging of specific, unlabelled molecular species
and could be particularly useful for visualizing lipids and small
molecules such as drugs.
Original research paper: Science 322, 1857–1861 (2008)
http://links.ealert.nature.com/ctt?kn=27&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=16&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
------------------------
Research Library
------------------------
INTERACTION BETWEEN TAK1-TAB1-TAB2 AND RCAN1-CALCINEURIN DEFINES A
SIGNALLING NODAL CONTROL POINT
Nature Cell Biology 11, 154-161 (2009)
http://links.ealert.nature.com/ctt?kn=29&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
AdPLA ABLATION INCREASES LIPOLYSIS AND PREVENTS OBESITY INDUCED BY
HIGH-FAT FEEDING OR LEPTIN DEFICIENCY
Nature Medicine 15, 159-168 (2009)
http://links.ealert.nature.com/ctt?kn=20&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
A GENETICALLY ENCODED FLUORESCENT REPORTER OF ATP:ADP RATIOS
Nature Methods 6, 161–166 (2009)
http://links.ealert.nature.com/ctt?kn=30&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
------------------------
Signaling News
------------------------
MEDICAL RESEARCH SCORES BIG IN US STIMULUS BILL
http://links.ealert.nature.com/ctt?kn=14&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
US President Barack Obama has signed the economic stimulus package
into law. The package contains some $21.5 billion for scientific
research and development across all federal agencies. See 'The
stimulus bill: who got what' for a breakdown of stimulus funding
by agency.
http://links.ealert.nature.com/ctt?kn=4&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
More news
http://links.ealert.nature.com/ctt?kn=22&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
-------------------------
Gateway Updates
-------------------------
PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - MARCH UPDATE
http://links.ealert.nature.com/ctt?kn=35&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative for
structural biologists to keep informed of the latest developments
in their field. This month's update features articles on:
Anthrax stealth molecule
http://links.ealert.nature.com/ctt?kn=32&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
Protein nanopores
http://links.ealert.nature.com/ctt?kn=10&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
http://links.ealert.nature.com/ctt?kn=28&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
-----------------------------
Job of the Week
-----------------------------
Manager, High-throughput Screening Facility
Employer: German Cancer Research Center
Location: Heidelberg, Germany
http://links.ealert.nature.com/ctt?kn=9&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
The Division of Signaling and Functional Genomics at the German
Cancer Research Center in Heidelberg seeks a manager for their
high-throughput screening facility. The successful applicant will
support on-going screens, develop new cell-based assays, perform
high-throughput RNAi and compound screens, and analyze data.
More Jobs:
http://links.ealert.nature.com/ctt?kn=11&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=21&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://links.ealert.nature.com/ctt?kn=6&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://links.ealert.nature.com/ctt?kn=31&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
For further technical assistance or any other enquiries, please click here:
http://links.ealert.nature.com/ctt?kn=1&m=31546534&r=MTc2ODc4NDI0MAS2&b=2&j=NDU5NTkzMjES1&mt=1&rt=0
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2009 Nature Publishing Group
---------------------------------------------------------------------
