March 2009 Volume 9 Number 3
Visit Nature Reviews Immunology online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=82&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text
access to Nature Reviews Immunology online. To purchase a
subscription, please visit:
http://links.ealert.nature.com/ctt?kn=18&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please
visit http://links.ealert.nature.com/ctt?kn=29&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
*********************************************************************
Nature Reviews Immunology Impact Factor: 28.3*
(*Journal Citation Reports, Thomson, 2007)
*********************************************************************
=========================== ADVERTISEMENT ===========================
IT'S NOW FREE TO POST YOUR VACANCY ON
naturejobs.com
http://links.ealert.nature.com/ctt?kn=83&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
It's the breakthrough you've been waiting for. Naturejobs.com - the
scientific jobs board from Nature now lets you advertise your vacancy
completely FREE OF CHARGE
Go to http://links.ealert.nature.com/ctt?kn=14&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0 or telephone:
Europe: +44 (0) 20 78434961
US: + 1 800 9897718
=====================================================================
=========================== ADVERTISEMENT ===========================
Nature Network New York is here!
Nature Network New York is the online meeting place where you can
connect with NYC-based scientists. Join the community on Nature
Network New York today to showcase your work, link up with
like-minded researchers and discuss issues that matter to you. It is
part of Nature Network, the professional networking website for
scientists.
Go to http://links.ealert.nature.com/ctt?kn=21&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0 to visit and join Nature
Network New York.
=====================================================================
=========================== ADVERTISEMENT ===========================
A Focus and Poster on CD4+ T-cell diversity
This Focus issue, produced with support from Schering-Plough, covers
the latest research on how the differentiation of TH-cell subsets and
regulatory T cells is controlled.
The Focus content is freely available for 6 months at
http://links.ealert.nature.com/ctt?kn=19&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
The accompanying poster, produced with support from UCB, shows the
signalling pathways that mediate the differentiation, survival,
function and plasticity of CD4+ T cells.
Download the poster for free at
http://links.ealert.nature.com/ctt?kn=95&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
=====================================================================
This month's FEATURED article:
Myeloid-derived suppressor cells as regulators of the immune system
Dmitry I. Gabrilovich and Srinivas Nagaraj
p162 | doi:10.1038/nri2506
http://links.ealert.nature.com/ctt?kn=5&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
=====================================================================
From the editors
p143 | doi:10.1038/nri2523
http://links.ealert.nature.com/ctt?kn=34&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
T-cell memory: The road not taken
p145 | doi:10.1038/nri2514
http://links.ealert.nature.com/ctt?kn=76&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Lymphocyte migration: 'Guided' tour of the brain
p146 | doi:10.1038/nri2509
http://links.ealert.nature.com/ctt?kn=69&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Innate immunity: Unfolding antiviral defences
p146 | doi:10.1038/nri2516
http://links.ealert.nature.com/ctt?kn=2&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Inflammation: Taking AIM in the cytoplasm
p147 | doi:10.1038/nri2511
http://links.ealert.nature.com/ctt?kn=15&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Tissue-specific immunity: Balancing act
p148 | doi:10.1038/nri2518
http://links.ealert.nature.com/ctt?kn=89&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Granulocyte development: Vitamin B3: a neutrophil supplement
p148 | doi:10.1038/nri2521
http://links.ealert.nature.com/ctt?kn=32&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Tumour immunology: Multi-tasking by STAT3
p149 | doi:10.1038/nri2517
http://links.ealert.nature.com/ctt?kn=90&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Antigen presentation: Parasite hijacking
p150 | doi:10.1038/nri2512
http://links.ealert.nature.com/ctt?kn=75&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Regulatory T cells: Suppression dissected
p150 | doi:10.1038/nri2513
http://links.ealert.nature.com/ctt?kn=31&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
IN BRIEF
Natural killer cells | Neuroimmunology | T-cell responses
p150 | doi:10.1038/nri2520
http://links.ealert.nature.com/ctt?kn=7&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
IN BRIEF
Haematopoiesis | T-cell responses | Cell migration
p151 | doi:10.1038/nri2519
http://links.ealert.nature.com/ctt?kn=39&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
----------------------
REVIEWS
----------------------
Article series: Tissue-specific immune responses
http://links.ealert.nature.com/ctt?kn=59&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Migration, maintenance and recall of memory T cells in peripheral
tissues
David L. Woodland and Jacob E. Kohlmeier
p153 | doi:10.1038/nri2496
Memory T cells in non-lymphoid tissues provide an important early
line of defence against secondary pathogen infection. In this
article, the mechanisms involved in the migration, maintenance and
function of memory T cells at these peripheral sites are discussed.
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Myeloid-derived suppressor cells as regulators of the immune system
Dmitry I. Gabrilovich and Srinivas Nagaraj
p162 | doi:10.1038/nri2506
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous
population of cells that expands during cancer, inflammation and
infection. Here, the authors discuss the mechanisms of MDSC expansion
and suppression of T-cell function in vivo, and describe how these
cells might be targeted for therapeutic purposes.
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
E and ID proteins branch out
Barbara L. Kee
p175 | doi:10.1038/nri2507
Haematopoiesis is driven by complex networks of transcriptional
regulators. Among them are the E and inhibitor of DNA binding (ID)
proteins, which have important roles in early B- and T-cell
development, as well as emerging roles in haematopoietic stem cells
and other lymphoid and myeloid lineages.
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=41&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
B-cell responses to vaccination at the extremes of age
Claire-Anne Siegrist and Richard Aspinall
p185 | doi:10.1038/nri2508
Infant and elderly humans and mice have a similar vulnerability to
common pathogens as a result of the decreased quantity and
persistence of antibody responses. This Review looks at the B-cell
intrinsic factors and microenvironmental determinants in lymphoid
tissue and bone marrow that limit protective B-cell responses in
these age groups.
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Regulation of B-cell proliferation and differentiation by pre-B-cell
receptor signalling
Sebastian Herzog, Michael Reth and Hassan Jumaa
p195 | doi:10.1038/nri2491
Signalling through the pre-B-cell receptor is an important checkpoint
in B-cell development. But, what are the molecular mechanisms that
regulate cell proliferation, immunoglobulin light chain gene
recombination and cell differentiation downstream of this receptor?
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
----------------------
PERSPECTIVES
----------------------
OPINION
Affinity threshold for thymic selection through a
T-cell receptor-co-receptor zipper
Ed Palmer and Dieter Naeher
p207 | doi:10.1038/nri2469
How the T-cell receptor translates ligand affinity to an appropriate
cellular response has puzzled immunologists for decades. In this
Opinion article, the authors propose a new model to explain this,
which is based on the duration of receptor-ligand binding and on a
'zipper' mechanism that mediates receptor-co-receptor interactions.
Abstract: http://links.ealert.nature.com/ctt?kn=80&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
SCIENCE AND SOCIETY
Maintaining protection against invasive bacteria with
protein-polysaccharide conjugate vaccines
Andrew J. Pollard, Kirsten P. Perrett and Peter C. Beverley
p213 | doi:10.1038/nri2494
In the light of the introduction of conjugate vaccines against
Haemophilus influenzae type B and group C meningococcal and
pneumococcal diseases over the past two decades, this Science &
Society article discusses the ways in which long-term protection
against these encapsulated bacteria might best be maintained at a
population level.
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
15 Evolutionary Gems
As the concepts and realities of Darwinian evolution are still
challenged, albeit rarely by biologists, Nature provides a succinct
empirically validated principle useful for people to have to hand. We
offer here 15 examples from over the past decade or so to illustrate
the breadth, depth and power of evolutionary thinking.
Access this resource from Nature, for those wishing to spread
awareness of evidence for evolution by natural selection FREE online
today!
http://links.ealert.nature.com/ctt?kn=51&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
=====================================================================
You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your nature.com
account at:
http://links.ealert.nature.com/ctt?kn=12&m=31717364&r=MTc2NzU2Mjg3MwS2&b=2&j=NDYxMTkyMTAS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration
department: registration@nature.com
For print subscription enquiries, please contact our subscription
department: subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
