March 2009 Volume 9 Number 3
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This month's FEATURED article:
Cell cycle, CDKs and cancer: a changing paradigm
Marcos Malumbres and Mariano Barbacid
p153 | doi:10.1038/nrc2602
http://links.ealert.nature.com/ctt?kn=56&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
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From the editors
p145 | doi:10.1038/nrc2616
http://links.ealert.nature.com/ctt?kn=4&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Cancer stem cells: Survival skills
p147 | doi:10.1038/nrc2614
http://links.ealert.nature.com/ctt?kn=46&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Signalling: Need for a CUL?
p148 | doi:10.1038/nrc2611
http://links.ealert.nature.com/ctt?kn=68&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Cancer stem cells: Killing hedgehog to treat CML
p148 | doi:10.1038/nrc2613
http://links.ealert.nature.com/ctt?kn=21&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
IN THE NEWS
Cannabis and cancer link
p148 | doi:10.1038/nrc2617
http://links.ealert.nature.com/ctt?kn=53&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Genetics: The importance of networking
p149 | doi:10.1038/nrc2612
http://links.ealert.nature.com/ctt?kn=34&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Tumorigenesis: Disconnecting Hedgehog from GLI
p150 | doi:10.1038/nrc2609
http://links.ealert.nature.com/ctt?kn=49&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Genetics: Networking on the fly
p150 | doi:10.1038/nrc2610
http://links.ealert.nature.com/ctt?kn=16&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Signalling: Pinning down Notch activation
p151 | doi:10.1038/nrc2606
http://links.ealert.nature.com/ctt?kn=76&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
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REVIEWS
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Cell cycle, CDKs and cancer: a changing paradigm
Marcos Malumbres and Mariano Barbacid
p153 | doi:10.1038/nrc2602
Misregulation of cyclin-dependent kinases (CDKs) can induce unscheduled
proliferation and genomic and chromosomal instability. How has recent genetic
evidence changed our understanding of the roles of CDKs in the cell cycle of
normal and tumour cells?
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Beyond chemotherapy: targeted therapies in ovarian cancer
Timothy A. Yap, Craig P. Carden and Stan B. Kaye
p167 | doi:10.1038/nrc2583
Relapse remains almost inevitable for patients with advanced ovarian
cancer. Can the introduction of novel targeted therapies affect the
management of this disease?
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=79&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Regulation of nitric oxide signalling by thrombospondin 1: implications
for anti-angiogenic therapies
Jeff S. Isenberg, Gema Martin-Manso, Justin B. Maxhimer and David D. Roberts
p182 | doi:10.1038/nrc2561
Thrombospondin 1, an endogenous angiogenesis inhibitor, affects nitric
oxide signalling and therefore haemostasis and blood flow. What is the
role of thrombospondin 1 in cancer and what can it teach us about
therapeutic inhibition of angiogenesis?
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
Hildegard M. Schuller
p195 | doi:10.1038/nrc2590
Neurotransmitters released through the activation of nicotinic acetylcholine
receptors (nAChRs) regulate the synthesis and release of growth, angiogenic
and neurotrophic factors. Evidence suggests that smoking and possibly other
factors increase the activity of certain nAChRs, and might therefore
contribute to tumour development.
Abstract: http://links.ealert.nature.com/ctt?kn=51&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
The molecular programme of tumour reversion: the steps beyond malignant
transformation
Adam Telerman and Robert Amson
p206 | doi:10.1038/nrc2589
The question of how cells become malignant has occupied scientists for
over a century. However, the converse question - are tumour cells
capable of reverting from their malignant state - is also valid,
as discussed in this article.
Abstract: http://links.ealert.nature.com/ctt?kn=65&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
OPINION
Palindromic gene amplification - an evolutionarily conserved role
for DNA inverted repeats in the genome
Hisashi Tanaka and Meng-Chao Yao
p216 | doi:10.1038/nrc2591
Gene amplification is an essential process in several organisms including
the ciliate Tetrahymena thermophila. What can amplification in this model
system teach us about mechanisms of amplification in cancer cells?
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
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CORRESPONDENCE
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Correspondence: The interaction between pro-inflammatory cytokines and
the nervous system
Alessio Molfino, Filippo Rossi-Fanelli and Alessandro Laviano
p224 | doi:10.1038/nrc2507-c1
http://links.ealert.nature.com/ctt?kn=63&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
Erratum: Insulin and insulin-like growth factor signalling in neoplasia
(Erratum)
Michael Pollak
p224 | doi:10.1038/nrc2605
http://links.ealert.nature.com/ctt?kn=78&m=31650030&r=MTc2Njc4NzkyNgS2&b=2&j=NDYwMzU4NTgS1&mt=1&rt=0
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