Signaling Update contents for 16 January 2009

	Signaling Update — 16 January 2009 Signaling Update is a one-stop online resource designed to keep you in touch with the latest and most exciting research in cell signaling. New content is uploaded every Friday.
	New in Signaling Update this week:
	featured article  Insulin signaling: Arrestin type 2 diabetes Insulin signaling elicits PI(3)K-independent activation of Akt by promoting the formation of an insulin receptor/β-arrestin-2/Src/Akt complex. Original paper: Nature advance online publication, 4 January 2009 (DOI 10.1038/nature07617) previous featured articles selected updates  Cell cycle: Destruct and arrest Two studies provide insight into how the activity of the ubiquitin-ligase anaphase-promoting complex (APC/C) is regulated during the cell cycle. Original research paper: Nature Cell Biol. 10, 1411-1420 (2008) Metastasis: Moved to act Differential activation of the small GTPases Rac and Rho determines whether tumor cells migrate using amoeboid-like or mesenchymal-like motion. Original research paper: Science 322, 963-966 (2008) Analgesia: Uncoupling NMDA receptor interactions Disrupting the interaction between N-methyl-D-aspartate receptors (NMDARs) and the protein tyrosine kinase Src blocks pain without causing respiratory and locomotory side effects. Original research paper: Nature Med. 14, 1325-1332 (2008) more updates research library  The Research Library brings together all recent signaling-related research published in the Nature Publishing Group journals. Divided up into subject categories or by date, you can be guaranteed to find what you are looking for. Here is a selection of the newest and hottest research published this week. A tunable synthetic mammalian oscillator Nature 457, 309-312 (2009) Subscribe to this journal Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy Nature Biotechnology 27, 77-83 (2008) Subscribe to this journal miR-29 miRNAs activate p53 by targeting p85[alpha] and CDC42 Nature Structural & Molecular Biology 16, 23-29 (2008) Subscribe to this journal signaling news  Handover: New opportunities, new obligations This week's issue of Nature contains special coverage of the challenges and opportunities faced by US president-elect Barack Obama. In ' Your inbox, Mr President', six advisers comment on key policy issues, from biosecurity to stem cell research. The News pages contain details of the planned economic stimulus package, and historical sound bites from Obama's nominees for top federal positions. more news gateway updates  NCI-Nature Pathway Interaction Database - January Update The Pathway Interaction Database is a free, high-quality resource of signaling pathways in human cells for biologists and bioinformaticians to explore, visualize and mine signaling events. Recently added molecular networks include Arf6 signaling events and the regulation of androgen receptor activity. Sign up here to receive the monthly update alert for the NCI-Nature Pathway Interaction Database. job of the week  from naturejobs the scientific careers resource Research Assistant/Associate Employer: University of Bristol Location: Bristol, United Kingdom A research assistant or research associate position is available at the University of Bristol in the laboratory of Dr. Ingeborg Hers. The successful applicant will apply biochemical, cell and molecular biology techniques to identify the kinases and/or signaling pathways that regulate phosphodiesterase 3A (PDE3A) function in human platelets. more jobs To advertise a job in this spot, please contact Naturejobs.
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