Nature Reviews Microbiology contents February 2009 Volume 7 Number 2 pp 89-171

TABLE OF CONTENTS
February 2009 Volume 7 Number 2
Impact Factor 14.959 * Subscribe to Nature Reviews Microbiology Recommend to your library	In this issue Research Highlights News and Analysis Reviews Perspective Also this month Article Series: Systems Microbiology  Featured article: Pyroptosis: host cell death and inflammation Tessa Bergsbaken, Susan L. Fink & Brad T. Cookson
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In this issue p89 | doi:10.1038/nrmicro2089 Full Text
Editorial: If you build it, they might come Roy Welch & Laura Welch p90 | doi:10.1038/nrmicro2086 Roy and Laura Welch examine why researchers seem reluctant to be more directly involved in the annotation of microbial genomes. Full Text | PDF
RESEARCH HIGHLIGHTS Top Pathogenesis: Sacre bleu — un assassin de nematode! p92 | doi:10.1038/nrmicro2076 PDF IN BRIEF Plant pathogens | Viral pathogenesis | Innate immunity p92 | doi:10.1038/nrmicro2079 PDF Environmental microbiology: Freezing energizes bacterial metabolism p93 | doi:10.1038/nrmicro2075 PDF Fungal genetics: Good things come to those who wait p93 | doi:10.1038/nrmicro2083 PDF Cellular microbiology: Breaking up (the Golgi) is hard to do p93 | doi:10.1038/nrmicro2084 PDF Host genetics: Opening the door to TB p94 | doi:10.1038/nrmicro2081 PDF Parasitology: The fatty liver stage of malaria parasites p94 | doi:10.1038/nrmicro2082 PDF Viral pathogenesis: IRES knocks out rabies p95 | doi:10.1038/nrmicro2078 PDF Microbiology JOBS of the week Research Fellow / Food Technology Istituto Agrario di San Michele All'Adige San Michele all'Adige Italy Professor ETH Zurich, Switzerland Assistant Professor Stanford University School of Medicine Stanford, CA 94305-5124 United States Senior Research Fellowship St. John's College Oxford Oxford United Kingdom Assistant / Associate / Project Scientist UCSD La Jolla, CA 92039-0739 United States More Science jobs from Microbiology EVENT MicroRNA in Human Disease and Development 23.-25.03.09 Boston, US More science events from
NEWS AND ANALYSIS		Top
DISEASE WATCH In the news p96 | doi:10.1038/nrmicro2088 PDF
REVIEWS		Top
Pyroptosis: host cell death and inflammation Tessa Bergsbaken, Susan L. Fink & Brad T. Cookson p99 | doi:10.1038/nrmicro2070 Microorganism- and host-derived signals can stimulate formation of a multiprotein complex called the inflammasome, which activates the cysteine protease caspase 1. In turn, caspase 1 triggers an inflammatory programmed cell death pathway known as pyroptosis. Numerous pathogens have evolved a mechanism to subvert pyroptosis and persist within infected cells. Abstract | Full Text | PDF
Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea V. K. Viswanathan, Kim Hodges & Gail Hecht p110 | doi:10.1038/nrmicro2053 Bacterial diarrhoea is caused by toxins that are secreted by a variety of bacterial species. These toxins target different host factors and cause loss of fluid and electrolytes, leading to diarrhoea. In addition, the host innate immune response plays an important part in modulating fluid loss. Abstract | Full Text | PDF
Prospects for improved bluetongue vaccines Polly Roy, Mark Boyce & Robert Noad p120 | doi:10.1038/nrmicro2052 Bluetongue virus is a substantial health risk to sheep and other ruminants. Livestock can be protected by vaccination, but as described in this Review, current vaccines can have severe drawbacks. New molecular techniques will provide safer and more effective vaccines and allow for better surveillance of the spread of vaccine strains. Abstract | Full Text | PDF
Article series: Systems Microbiology Reconstruction of biochemical networks in microorganisms Adam M. Feist, Markus J. Herrgård, Ines Thiele, Jennie L. Reed & Bernhard Ø. Palsson p129 | doi:10.1038/nrmicro1949 In this Review, Bernhard Palsson and colleagues describe the steps that are necessary for reconstruction of genomic-scale biochemical reaction networks based on systems analysis of microorganisms. This article provides guidelines for the reconstruction of metabolic, transcription and translation and transcriptional regulatory networks. Abstract | Full Text | PDF | Supplementary information
Apoptosis in animal models of virus-induced disease Penny Clarke & Kenneth L. Tyler p144 | doi:10.1038/nrmicro2071 Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes morbidity and mortality. Animal models of virus-induced diseases provide insights into the role of apoptosis in pathogenesis, the pathways involved and potential therapeutic implications. Abstract | Full Text | PDF
Organophosphorus-degrading bacteria: ecology and industrial applications Brajesh K. Singh p156 | doi:10.1038/nrmicro2050 Many environments are contaminated with organophosphate (OP) compounds, and OP use has resulted in a public health hazard, as approximately 3 million individuals are poisoned and 300,000 die owing to OP ingestion each year. Bioremediation of OPs is therefore of prime importance. This Review discusses the microbiology, biochemistry, genetics and evolution of the industrially important OP-degrading bacteria. Abstract | Full Text | PDF
PERSPECTIVE		Top
OPINION Intracellular pathogenic bacteria and fungi — a case of convergent evolution? James B. Bliska & Arturo Casadevall p165 | doi:10.1038/nrmicro2049 Similarities between the intracellular pathogenic strategies of the bacterium Yersinia pestis and the fungus Cryptococcus neoformans are used to illustrate the author's proposal that these pathogens acquired their intracellular survival strategies by a process of convergent evolution, possibly in response to interactions with other hosts in the environment, such as amoebae. Abstract | Full Text | PDF
Erratum: The curious case of the tumour virus: 50 years of Burkitt's lymphoma David A. Thorley-Lawson & Martin J. Allday p172 | doi:10.1038/nrmicro2068 Full Text | PDF
Erratum: How do bacterial cells ensure that metalloproteins get the correct metal? Kevin J. Waldron & Nigel J. Robinson p172 | doi:10.1038/nrmicro2074 Full Text | PDF
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