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TABLE OF CONTENTS |
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February 2009 Volume 9 Number 2 |
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Impact Factor 28.3 * | In this issue Research Highlights Foreword Focus on: CD4+ T-cell diversity
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A Focus and Poster on CD4+ T-cell diversity This Focus issue, produced with support from Schering-Plough, covers the latest research on how the differentiation of TH-cell subsets and regulatory T cells is controlled. The Focus content is freely available for 6 months at www.nature.com/nri/focus/cd4t-celldiversity The accompanying poster, produced with support from UCB, shows the signalling pathways that mediate the differentiation, survival, function and plasticity of CD4+ T cells. Download the poster for free at www.nature.com/nri/posters/cd4t-celldiversity | |
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From the editors p71 | doi:10.1038/nri2492 PDF |
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FOREWORD
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Decision making during the conception and career of CD4+ T cells Steven L. Reiner p81 | doi:10.1038/nri2490 Abstract | Full Text | PDF |
Focus on: CD4+ T-cell diversity | PROGRESS | Top | Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Jochen Huehn, Julia K. Polansky & Alf Hamann p83 | doi:10.1038/nri2474 Regulatory T (TReg) cells are crucial for immune homeostasis, and manipulation of their suppressive functions is a possible avenue for immunotherapy. Here, the authors discuss recent advances in our understanding of how the expression of forkhead box P3 (FOXP3), a TReg-cell-specifying transcription factor, is controlled at the molecular level. Abstract | Full Text | PDF |
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Focus on: CD4+ T-cell diversity | REVIEWS | Top | Epigenetic control of T-helper-cell differentiation Christopher B. Wilson, Emily Rowell & Masayuki Sekimata p91 | doi:10.1038/nri2487 Numerous lineage-specific transcription factors have been linked with T-helper-cell subset specification. But, as discussed here, epigenetic modifications at the gene regulatory elements where these factors bind can also contribute to the regulation of T-helper-cell differentiation and function. Abstract | Full Text | PDF
| RUNX proteins in transcription factor networks that regulate T-cell lineage choice Amélie Collins, Dan R. Littman & Ichiro Taniuchi p106 | doi:10.1038/nri2489 In this Review, the authors discuss how RUNX (runt-related transcription factor) proteins and other key transcription factors work together to direct T-cell lineage choice and CD4+ T-cell differentiation. Abstract | Full Text | PDF
| The different faces of Notch in T-helper-cell differentiation Derk Amsen, Andrey Antov & Richard A. Flavell p116 | doi:10.1038/nri2488 Recent research indicates that the Notch signalling pathway is important for directing T helper (TH)-cell differentiation. In this Review, the authors discuss contrasting results showing that Notch can have a role in both TH1- and TH2-cell differentiation, and highlight how this information might help to better understand the pathology of T-cell-mediated diseases. Abstract | Full Text | PDF
| GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation I-Cheng Ho, Tzong-Shyuan Tai & Sung-Yun Pai p125 | doi:10.1038/nri2476 The transcription factor GATA-binding protein 3 (GATA3) is best known as a master regulator of T-helper-2-cell differentiation. However, as part of a network of other transcription factors, GATA3 is also important in determining cell fate at earlier stages of haematopoiesis and lymphoid-cell development. Abstract | Full Text | PDF
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Focus on: CD4+ T-cell diversity | PERSPECTIVE | Top | OPINION Regulation of T-helper-cell lineage development by osteopontin: the inside story Harvey Cantor & Mari L. Shinohara p137 | doi:10.1038/nri2460 Here, Harvey Cantor and Mari Shinohara propose that the secreted and intracellular isoforms of osteopontin differentially regulate the development of distinct T-helper-cell subsets and, consequently, adaptive immune responses to foreign and self antigens. Abstract | Full Text | PDF
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Special Issue on TGF? Signaling Cell Research is delighted to bringing you a Special Issue on TGF? Signaling. Highlighting the latest on the molecular mechanisms, regulation and biological functions of TGF? signaling, this issue and accompanying web focus features articles spanning the NPG portfolio including Cell Research, Nature, Nature Cell Biology and Nature Immunology. Take advantage of this Special Issue on TGF? Signaling today! | |
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