January 2009 Volume 11 Number 1, pp 1 - 110
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EDITORIAL
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Credit where credit is due
Citations are an important component in the assessment of academic
performance. Yet, the growing literature, combined with format constraints
of journals, encourage citation of reviews in preference to
primary research. This diverts academic credit from the discoverer.
doi:10.1038/ncb0109-1
http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-1.html
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BOOK REVIEW
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TGF-beta signalling unfolds p2
Stefano Piccolo reviews The TGF-beta family by Rik Derynck and Kohei Miyazono
doi:10.1038/ncb0109-2
http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-2.html
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MEETING REPORT
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Shaping embryos in Barcelona pp3 - 6
Michel Labouesse and Lilianna Solnica-Krezel
doi:10.1038/ncb0109-3
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb0109-3.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-3.html
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NEWS AND VIEWS
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Membrane repair redux: redox of MG53 pp7 - 9
Most cells can rapidly repair extensive tears in their plasma membrane,
a response dependent on extracellular calcium. Entry of extracellular
oxidants through a membrane disruption oxidizes and thus activates
a newly discovered membrane repair protein, MG53, in skeletal muscle cells.
Paul McNeil
doi:10.1038/ncb0109-7
http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-7.html
Undressing a cellular corset: septins exposed pp9 - 10
Septins comprise a conserved family of cytoskeletal proteins distinct from
the microfilament, microtubule and intermediate filament systems. They
are GTPases that have been implicated in a number of cellular processes
ranging from mitosis to vesicular trafficking. A new study identifies a
previously undefined role for septins as cellular 'corsets', modulating
cell shape and providing cortical rigidity in T cells that allows for their
controlled migration.
Melissa C. Srougi and Keith Burridge
doi:10.1038/ncb0109-9
http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-9.html
Ran out of the nucleus for apoptosis pp11 - 12
Induction of apoptosis causes active dissipation of the RanGTP gradient
across an intact nuclear envelope by immobilizing RCC1, the guanine
nucleotide exchange factor for RanGTPase, on chromatin. The subsequent
reduction in nuclear trafficking prevents the movement of NF-kappaB into
the nucleus, thereby allowing apoptosis to proceed.
Andrew Wilde and Yixian Zheng
doi:10.1038/ncb0109-11
http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-11.html
sFRPs: a declaration of (Wnt) independence p13
Secreted Frizzled-related proteins (sFRPs) are signalling molecules
well-known as antagonists of the Wnt pathway, but recent studies
indicate that they may have additional functions unrelated to Wnt.
A new study demonstrates that mammalian sFRP2 can act as an
enhancer of collagen processing in vitro and in vivo, augmenting
myocardial injury-driven fibrosis. These findings underscore the
biological versatility of sFRP family members.
Elisha Nathan and Eldad Tzahor
doi:10.1038/ncb0109-13
http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-13.html
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RESEARCH HIGHLIGHTS
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Research highlights p15
Silvia Grisendi, Nathalie Le Bot, Christina Karlsson Rosenthal and
Sowmya Swaminathan
doi:10.1038/ncb0109-15
http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-15.html
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ARTICLES
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Amoeboid T lymphocytes require the septin cytoskeleton for cortical
integrity and persistent motility pp17 - 26
Septins are cytoskeletal proteins that form a ring at the cytokinetic
furrow. Now an analogous 'molecular corset' of septins is found to
be required for T lymphocyte migration.
Aaron J. Tooley et al.
doi:10.1038/ncb1808
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1808.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1808.html
Genome stability is ensured by temporal control of kinetochore-microtubule
dynamics pp27 - 35
Incorrectly oriented chromosomes in mitosis can lead to chromosome
instability and aneuploidy. The kinesins Kif2b and MCAK stimulate
kinetochore-microtubule dynamics to correct mis-orientations.
Samuel F. Bakhoum, Sarah L. Thompson, Amity L. Manning and Duane A. Compton
doi:10.1038/ncb1809
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1809.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1809.html
Apoptotic histone modification inhibits nuclear transport by regulating RCC1
pp36 - 45
The guanine nucleotide exchange factor for Ran, RCC1, dynamically binds
chromatin. During apoptosis, caspase-mediated activation of Mst1 induces
histone H2B phosphorylation, which immobilizes RCC1 on the chromatin,
leading to a reduction in nuclear RanGTP.
Chi-Hang Wong et al.
doi:10.1038/ncb1810
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1810.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1810.html
Secreted Frizzled-related protein 2 is a procollagen C proteinase
enhancer with a role in fibrosis associated with myocardial infarction pp46 - 55
Secreted frizzled-related proteins (sFRPs) were reported to antagonise
Chordin processing by Sizzled, a tolloid-like metalloproteinase in Xenopus
and zebrafish. Surprisingly, mammalian sFRP2 enhances the activity of
tolloid-like metalloproteinases on procollagen C to modulate fibrosis
associated with cardiac injury.
Koichi Kobayashi et al.
doi:10.1038/ncb1811
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1811.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1811.html
MG53 nucleates assembly of cell membrane repair machinery pp56 - 64
A phosphatidylserine-binding protein, MG53, is shown to participate in
membrane repair. MG53 recruits vesicles to the repair site in an oxidation
dependent manner and MG53-null mice develop progressive myopathy
associated with defective membrane repair.
Chuanxi Cai et al.
doi:10.1038/ncb1812
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1812.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1812.html
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LETTERS
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Midbody ring disposal by autophagy is a post-abscission event of
cytokinesis pp65 - 70
The midbody ring connects two dividing cells at the end of cytokinesis.
Depletion of autophagy components or inhibition of lysosomal function
result in accumulation of midbody rings.
Christian Pohl and Stefan Jentsch
doi:10.1038/ncb1813
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1813.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1813.html
Regulation of cytokinesis by Rho GTPase flux pp71 - 77
In cytokinesis, formation of the contractile ring depends on localized
activation of RhoA at the cell equator. This study demonstrates that
GAP activity of MgcRacGAP is necessary throughout cytokinesis to
maintain a focused zone of Rho activity.
Ann L. Miller and William M. Bement
doi:10.1038/ncb1814
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1814.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1814.html
Auxin transport through non-hair cells sustains root-hair development pp78 - 84
As the root develops, auxin transport through non-hair cells sustains
root-hair outgrowth. Mathematical modelling and experimental data reveal
that auxin is transported through canals across the non-hair cells.
Angharad R. Jones et al.
doi:10.1038/ncb1815
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1815.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1815.html
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex
of the hypoxic response pp85 - 91
The ubiquitin ligase Siah2 targets HIPK2 kinase for degradation during
hypoxia. During normoxia, however, the kinase is stable, as phosphorylation
of Siah2 by HIPK2 weakens the interaction.
Marco A. Calzado et al.
doi:10.1038/ncb1816
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1816.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1816.html
Activation of ATM depends on chromatin interactions occurring before
induction of DNA damage pp92 - 96
Doubled-stranded DNA breaks activate ATM kinase, precipitating a DNA
damage response. The nucleosome-binding protein HMGN1 governs ATM
activation by inducing H3K14 acetylation, which regulates chromatin binding
of ATM both before and after DSB formation.
Yong-Chul Kim et al.
doi:10.1038/ncb1817
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1817.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1817.html
Essential role of Pin1 in the regulation of TRF1 stability and telomere
maintenance pp97 - 105
The prolyl isomerase Pin1 acts in various cellular processes. It has now
been implicated in telomere maintenance by regulating the stability of the
telomere binding protein TRF1.
Tae Ho Lee et al.
doi:10.1038/ncb1818
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1818.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1818.html
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BRIEF COMMUNICATION
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Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning pp106 - 109
Hiroshi Hanafusa, Kunihiro Matsumoto and Eisuke Nishida
doi:10.1038/ncb1820
Abstract: http://www.nature.com/ncb/journal/v11/n1/abs/ncb1820.html
Article: http://www.nature.com/ncb/journal/v11/n1/full/ncb1820.html
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ERRATUM
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X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility p110
Taner Dogan et al.
doi:10.1038/ncb0109-110
http://www.nature.com/ncb/journal/v11/n1/full/ncb0109-110.html
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Nature Reviews Molecular Cell Biology
Focus on Mechanotransduction
Cellular responses to mechanical forces drive morphogenesis, regulate normal physiology and contribute to pathogenesis of many diseases. This special Focus reflects our current understanding of mechanotransduction in processes such as cell adhesion, vascular physiology, development and neurosensing.
The Focus content is FREE during the month of January. To access the Focus articles, visit:
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