1 January 2009 Volume 457 Number 7225, pp 7 - 122
Visit Nature online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=100&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text access to
Nature online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=24&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=48&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
EDITORIALS
----------------------
Starry messages p7
The first scientific observations with telescopes displaced Earth from the centre
of the Universe. Modern technology continues to humble us but should not distance
us from the cosmos itself.
doi:10.1038/457007a
http://links.ealert.nature.com/ctt?kn=168&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Experts still needed pp7-8
There are good reasons to be suspicious of metric-based research assessment.
doi:10.1038/457007b
http://links.ealert.nature.com/ctt?kn=116&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
A public service p8
The Christmas bird count is a model to be emulated in distributed, volunteer science.
doi:10.1038/457008a
http://links.ealert.nature.com/ctt?kn=25&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Announcement: Evolutionary gems p8
doi:10.1038/457008b
http://links.ealert.nature.com/ctt?kn=114&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
NEWS
----------------------
Obama's picks underline climate focus pp10-11
Strong roles for biologists as the president-elect chooses his science and
technology team.
Eric Hand and Alexandra Witze
doi:10.1038/457010a
http://links.ealert.nature.com/ctt?kn=115&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Universities struggle as value of endowments falls pp11-12
Tough decisions need to be made about how to cut costs.
Eric Hand
doi:10.1038/457011a
http://links.ealert.nature.com/ctt?kn=176&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Good grades, but who gets the cash? p13
Britain's Research Assessment Exercise finds excellence more widespread than a
focus on elite institutions would suggest.
Natasha Gilbert
doi:10.1038/457013a
http://links.ealert.nature.com/ctt?kn=214&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Single fund for African science aid p14
Cash pool could break power struggles between competing agencies on the continent.
Linda Nordling
doi:10.1038/457014a
http://links.ealert.nature.com/ctt?kn=178&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Medical charity folds after investment losses pp16-16
doi:10.1038/457016a
http://links.ealert.nature.com/ctt?kn=185&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Spanish solar companies slammed over subsidy fraud p16
doi:10.1038/457016b
http://links.ealert.nature.com/ctt?kn=47&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
US firms power up to build advanced batteries pp16-16
doi:10.1038/457016c
http://links.ealert.nature.com/ctt?kn=82&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Health organization lays plans for major biobank p16
doi:10.1038/457016d
http://links.ealert.nature.com/ctt?kn=42&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
NASA awards contracts to supply space station pp16-16
Ashley Yeager
doi:10.1038/457016e
http://links.ealert.nature.com/ctt?kn=123&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
First antenna switches on in the Atacama pp16-16
Geoff Brumfiel
doi:10.1038/457016f
http://links.ealert.nature.com/ctt?kn=172&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
CORRECTION
----------------------
Correction pp16-16
doi:10.1038/457016g
http://links.ealert.nature.com/ctt?kn=74&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
COLUMN
----------------------
The new boss in town pp17-17
Barack Obama's transition team is hitting the ground running, and its speed
and openness are winning praise, as David Goldston reports.
doi:10.1038/457017a
http://links.ealert.nature.com/ctt?kn=202&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
NEWS FEATURE
----------------------
Year of astronomy: New eyes, new skies pp18-25
The next 40 years will see telescopes that far outstrip any ever seen before.
Jeff Kanipe profiles four of them; illustrations by Lynette Cook.
doi:10.1038/457018a
http://links.ealert.nature.com/ctt?kn=207&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
Obama must match science rhetoric with action p26
Lisa Borghesi
doi:10.1038/457026a
http://links.ealert.nature.com/ctt?kn=33&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Problems with anti-plagiarism database p26
Mauno Vihinen
doi:10.1038/457026b
http://links.ealert.nature.com/ctt?kn=137&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Honeybee and the Phoenix analysing instrument p26
William V. Boynton
doi:10.1038/457026c
http://links.ealert.nature.com/ctt?kn=96&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
COMMENTARY
----------------------
Time to turn off the lights p27
Cities needlessly shine billions of dollars directly into the sky each year
and, as a result, a fifth of the world's population cannot see the Milky Way.
Malcolm Smith explains why a dark sky has much to offer everyone.
doi:10.1038/457027a
http://links.ealert.nature.com/ctt?kn=90&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
ESSAY
----------------------
Year of astronomy: Mankind's place in the Universe pp28-29
Technological developments in astronomy have long helped to answer some of the
greatest questions tackled by humanity, recounts Owen Gingerich.
doi:10.1038/457028a
http://links.ealert.nature.com/ctt?kn=153&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
BOOKS AND ARTS
----------------------
Year of astronomy: Visions of ourselves p30
The view of our planet from space is beautiful and humbling, yet this shift in
human perspective has not altered how we care for our environment, argues
Charles Cockell.
Charles Cockell reviews Earthrise: How Man First Saw the Earth by Robert Poole
doi:10.1038/457030a
http://links.ealert.nature.com/ctt?kn=91&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Year of astronomy: Q&A: One giant leap for art p31
Astronaut Alan Bean stepped down onto the lunar surface during the 1969 Apollo 12
mission, but left NASA in 1981 to devote himself to painting. With exhibitions of
his work taking place this year to celebrate the 40th anniversary of the first
Moon landing, he tells Nature how he attempts to convey his lunar experience.
Daniel Cressey
doi:10.1038/457031a
http://links.ealert.nature.com/ctt?kn=30&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Year of astronomy: Voyaging to discovery, alone pp31-32
David Bodanis reviews The Age of Wonder: How the Romantic Generation Discovered the
Beauty and Terror of Science by Richard Holmes
doi:10.1038/457031b
http://links.ealert.nature.com/ctt?kn=77&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Year of astronomy: Star poetry p32
doi:10.1038/457032a
http://links.ealert.nature.com/ctt?kn=132&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Year of astronomy: Hidden treasures: the Paris Observatory p33
Giovanni Domenico Cassini helped to create an institution that pinpointed Neptune,
showed that light had a finite speed -- and even mapped France, explains Alison Abbott.
Alison Abbott
doi:10.1038/457033a
http://links.ealert.nature.com/ctt?kn=83&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Quantum physics: Squeeze until it hurts pp35-36
Quantum systems are uncertain by nature. By 'squeezing' this uncertainty, physicists
can make better measurements of quantities such as distance. But overdoing it makes
things burst out all over the place.
Geoff J. Pryde
doi:10.1038/457035a
http://links.ealert.nature.com/ctt?kn=93&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
50 & 100 years ago p36
doi:10.1038/457036a
http://links.ealert.nature.com/ctt?kn=66&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Cancer: Inflaming metastasis pp36-37
Cancer can be defined by six hallmarks, including uncontrollable growth, immortality and
the ability to invade other tissues. Increasing evidence suggests that a seventh feature
should make this list -- inflammation.
Alberto Mantovani
doi:10.1038/457036b
http://links.ealert.nature.com/ctt?kn=84&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Astrophysics: Star formation branches out pp37-39
Deciphering how stars form within turbulent, dense clouds of molecular gas has been a
challenge. An innovative technique that uses a tree diagram provides insight into the process.
Ralph E. Pudritz
doi:10.1038/457037a
http://links.ealert.nature.com/ctt?kn=110&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Game theory: How to treat those of ill repute pp39-40
A much-needed theoretical analysis deals with whether the principle known as 'costly punishment'
helps to maintain cooperation in human society. It will prompt a fresh wave of experiments
and theory.
Bettina Rockenbach and Manfred Milinski
doi:10.1038/457039a
http://links.ealert.nature.com/ctt?kn=127&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Darwin 200: A natural selection p40
doi:10.1038/457040a
http://links.ealert.nature.com/ctt?kn=217&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
REVIEW
----------------------
18 years of science with the Hubble Space Telescope pp41-50
No colour figure form or editor's summary needed.
Julianne J. Dalcanton
doi:10.1038/nature07621
Abstract: http://links.ealert.nature.com/ctt?kn=200&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
ARTICLES
----------------------
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells pp51-56
After expression of the PML-RAR oncogene in haematopoietic stem cells, p21 is necessary to limit
cell cycle progression and thus limit the accumulation of DNA damage which would otherwise limit
the self-renewal of leukaemic stem cells and prevent the development of leukaemia
Andrea Viale et al.
doi:10.1038/nature07618
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=194&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity pp57-62
An early cellular response to the occurrence of DNA double-strand breaks in mammals is the
phosphorylation of the specialized histone variant H2A.X at Ser 139. The chromatin remodelling
factor WSTF is found to phosphorylate H2A.X at another site, Tyr 142. Tyrosine phosphorylation
has not been observed previously on histones.
Andrew Xiao et al.
doi:10.1038/nature07668
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
LETTERS
----------------------
A role for self-gravity at multiple length scales in the process of star formation pp63-66
Self-gravity plays a decisive role in the final stages of star formation, where dense cores
inside molecular clouds collapse to form star-plus-disk systems. But the role of self-gravity
at earlier times is unclear. This paper reports a dendogram analysis that reveals that
self-gravity plays a significant role over the full range of scales traced by 13CO observations
in L1448, but not everywhere in the observed region.
Alyssa A. Goodman et al.
doi:10.1038/nature07609
Abstract: http://links.ealert.nature.com/ctt?kn=101&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Squeezing and over-squeezing of triphotons pp67-70
Quantum measurements are subject to an uncertainty that is usually distributed equally between
pairs of complementary properties (such as position and momentum). However, a technique known
as 'squeezing' can be used to reduce the uncertainty of one desired property at the expense of
increasing that of the other. Squeezing may have a critical role in high precision applications
such as atomic clocks and optical communications. This paper demonstrates the ultimate squeezing
limit for the polarization of a composite optical system.
L. K. Shalm, R. B. A. Adamson and A. M. Steinberg
doi:10.1038/nature07624
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides pp71-75
This paper describes the combination of near-field optical forces (such as those used in optical traps)
to confine nanoscopic matter inside a liquid core-slot waveguide and photon scattering forces to
transport them. The waveguide overcomes the diffraction limits of conventional optical trapping
systems to manipulate objects down to tens of nanometres in scale. As the waveguide is linear, it
can also manipulate extended biomolecules demonstrated by trapping and transporting DNA molecules.
Allen H. J. Yang et al.
doi:10.1038/nature07593
Abstract: http://links.ealert.nature.com/ctt?kn=205&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=136&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Seismic evidence for overpressured subducted oceanic crust and megathrust fault sealing pp76-78
This study models converted teleseismic waves to constrain the seismological properties of
subducted oceanic crust from the Cascadia continental margin to its intersection with the
forearc mantle. The observations suggest that water is pervasively present in fluid form at
high pore pressures, indicating that the megathrust is a low-permeability boundary. These
results may hold important implications for our understanding of seismogenesis, subduction-zone
structure and the mechanism of episodic tremor and slip.
Pascal Audet, Michael G. Bostock, Nikolas I. Christensen and Simon M. Peacock
doi:10.1038/nature07650
Abstract: http://links.ealert.nature.com/ctt?kn=144&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Indirect reciprocity provides only a narrow margin of efficiency for costly punishment pp79-82
In human societies, altruistic behaviour can evolve because those who fail to co-operate are
lumbered with a bad reputation. This study explores the circumstances under which punishment
is favoured using a game theory model in which all individuals observe the interactions between
others and assess their reputation under various social norms. It is shown that punishment is
only a successful strategy under a narrow set of parameters, including the relative costs of
punishment and cooperation, the reliability of reputations and the spread of gossip.
Hisashi Ohtsuki, Yoh Iwasa and Martin A. Nowak
doi:10.1038/nature07601
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Emergence of complex cell properties by learning to generalize in natural scenes pp83-86
Complex visual scenes are made up of many component features, such as edges and textures.
Neurons in early stages of the visual system are sensitive to individual features, and it
is implicitly believed that the nervous system must put them back together to signal
conjunctions of different features, but how this is achieved is unknown. This paper proposes
a model in which neural activity encodes statistical variations of features in images,
thereby allowing the visual system to generalize across variable images.
Yan Karklin and Michael S. Lewicki
doi:10.1038/nature07481
Abstract: http://links.ealert.nature.com/ctt?kn=173&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys pp87-91
Vaccine elicted Gag specific cellular immune responses are shown to provide a measure of
protection from disease in Mamu-A ast 01-negative rhesus monkeys challenged with SIVMAC251.
Jinyan Liu et al.
doi:10.1038/nature07469
Abstract: http://links.ealert.nature.com/ctt?kn=191&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche pp92-96
High resolution combined confocal and two-photon video imaging of individual haematopoietic
cells is performed in the bone marrow of living animals, examining their relationship to blood
vessels, osteoblasts and endosteal surface as they home and engraft. It is found that
osteoblasts were enmeshed in microvessals and different populations of haematopoeitic cells
were localized in different areas according to their stage of differentiation. In settings of
engraftment as well as expansion, marrow stem/progenitor cells were in closer
proximity to bone and osteoblasts.
Cristina Lo Celso et al.
doi:10.1038/nature07434
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=208&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Detection of functional haematopoietic stem cell niche using real-time imaging pp97-101
Recently haematopoietic stem cell niches have been shown to comprise osteoblastic and vascular
microenvironments. This study describes a newly developed ex vivo real-time imaging technology
and immunoassaying to trace the homing of highly purified GFP-expressing haematopoietic stem cells
in response to irradiation.
Yucai Xie et al.
doi:10.1038/nature07639
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis pp102-106
Lung carcinoma cells were found to secrete the extracellular matrix proteoglycan versican.
Versican directly activates the TLR2 receptor complex on macrophages, which in turn promotes
tumour metastasis by producing TNF-?. Thus cancer cells utilize signalling pathways of the
innate immune system to support metastatic spread.
Sunhwa Kim et al.
doi:10.1038/nature07623
Abstract: http://links.ealert.nature.com/ctt?kn=152&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Chaperonin complex with a newly folded protein encapsulated in the folding chamber pp107-110
This study presents the structure of gp23-chaperonin complexes showing gp23 encapsulated in
the folding chamber. The folding chamber is distorted to enclose a large substrate, and this
is the first study that visualizes of a newly folded physiological substrate trapped inside
the folding chamber of GroEL.
D. K. Clare et al.
doi:10.1038/nature07479
Abstract: http://links.ealert.nature.com/ctt?kn=138&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=147&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation pp111-114
Recently, the first crystal structure of a pentameric ligand-gated ion channel known as GLIC
was published, which represented a closed state of the channel. In two papers in this issue,
presumptive open states of a related channel -- ELIC -- have been crystallized and show
significant tilting of the M2 and M3 alpha-helices from the
closed state.
Nicolas Bocquet et al.
doi:10.1038/nature07462
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=193&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel pp115-118
Recently, the first crystal structure of a pentameric ligand-gated ion channel known as GLIC
was published, which represented a closed state of the channel. In two papers in this issue,
presumptive open states of a related channel -- ELIC -- have been crystallized and show
significant tilting of the M2 and M3 alpha-helices from the
closed state.
Ricarda J. C. Hilf and Raimund Dutzler
doi:10.1038/nature07461
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=120&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
Naturejobs
----------------------
Prospects
Journey's end p119
The Postdoc Journal keepers of 2008 offer parting thoughts on a year of personal and professional milestones.
Gene Russo
doi:10.1038/nj7225-119a
http://links.ealert.nature.com/ctt?kn=190&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Gravitational astronomy 101 p122
It's a bit of a shock.
David Blair
doi:10.1038/457122a
http://links.ealert.nature.com/ctt?kn=112&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
31 December 2008
Calcium flickers steer cell migration
Chaoliang Wei et al.
doi:10.1038/nature07577
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=203&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
The Fas-FADD death domain complex structure unravels signalling by receptor clustering
Fiona L. Scott et al.
doi:10.1038/nature07606
Abstract: http://links.ealert.nature.com/ctt?kn=209&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=146&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Pyrrolysyl-tRNA synthetase-tRNAPyl structure reveals the molecular basis of orthogonality
Kayo Nozawa et al.
doi:10.1038/nature07611
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Casein kinase 1 agr governs antigen-receptor-induced NF- kgr B activation and human
lymphoma cell survival
Nicolas Bidere et al.
doi:10.1038/nature07613
Abstract: http://links.ealert.nature.com/ctt?kn=126&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=159&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Photon capture and signalling by melanopsin retinal ganglion cells
Michael Tri H. Do et al.
doi:10.1038/nature07682
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=22&m=30815630&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ2MzI1NDgS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2009 Nature Publishing Group
=====================================================================
