Signaling Gateway - 19 December 2008
http://links.ealert.nature.com/ctt?kn=38&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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NF-KAPPAB SIGNALING: BRIDGING THE NONCANONICAL GAP
Cellular inhibitors of apoptosis (cIAPs) ubiquitylate TRAF3 in a
TRAF2-dependent manner, leading to NF-kappaB-inducing kinase (NIK)
stabilization and the activation of the noncanonical NF-kappaB
pathway.
Original research paper: Nature Immunology, 9, 1364-1370 (2008)
http://links.ealert.nature.com/ctt?kn=18&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
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Molecule Pages
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2008: The year in Molecule Pages
In 2008, we published 101 Molecule Pages on signaling proteins
ranging from G-protein-coupled receptors to E2 SUMO conjugating
enzymes. The top five most popular Molecule Pages published this year
were Vav2, Integrin alphaL, mTOR, PTP1B and Rab8a. We also added new
links to external databases in our Automated Data section to the
Pathway Interaction Database, GEO and ArrayExpress. Thanks to our
authors, reviewers and readers for your support and interest in the
Molecule Pages over 2008. We look forward to another successful year
with many new publications in 2009!
http://links.ealert.nature.com/ctt?kn=14&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=40&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=24&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=12&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=30&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=22&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
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Selected Updates
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IMMUNOTHERAPY: DESIGNER SIRNA
A short interfering RNA (siRNA) has been designed that acts as a
potent antitumor agent not only by silencing the expression of the
anti-apoptotic gene Bcl2 (B-cell lymphoma 2) but also by triggering
the innate immune receptor RIG-I (retinoic-acid-inducible gene I) to
induce an antitumor immune response.
Original research paper: Nature Med. 14, 1256-1263 (2008)
http://links.ealert.nature.com/ctt?kn=27&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
GLIOBLASTOMA: STOP ACTING SO IMMATURE
In humans, PTEN mutations are typically found in high-grade primary
glioblastoma multiforme (GBM), whereas TP53 mutations are more common
in secondary GBM; however, tumors in mice lacking both Pten and Trp53
in the CNS bear a striking resemblance to primary GBM in humans.
Original research paper: Nature 455, 1129-1133 (2008)
http://links.ealert.nature.com/ctt?kn=35&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
TECHNOLOGY: COMPUTING IN A CELL
A synthetic RNA device has been constructed that can integrate into
and act on various molecular signals in a yeast system.
Original research paper: Science 322, 456-460 (2008)
http://links.ealert.nature.com/ctt?kn=3&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=26&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
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Research Library
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MICRORNA-21 CONTRIBUTES TO MYOCARDIAL DISEASE BY STIMULATING MAP
KINASE SIGNALLING IN FIBROBLASTS
Nature 456, 980-984 (2008)
http://links.ealert.nature.com/ctt?kn=32&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
EFFECTIVE USE OF PI3K AND MEK INHIBITORS TO TREAT MUTANT KRAS G12D
AND PIK3CA H1047R MURINE LUNG CANCERS
Nature Medicine 14, 1351-1356 (2008)
http://links.ealert.nature.com/ctt?kn=31&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
MICROPATTERNING FOR QUANTITATIVE ANALYSIS OF PROTEIN-PROTEIN
INTERACTIONS IN LIVING CELLS
Nature Methods 5, 1053-1060 (2008)
http://links.ealert.nature.com/ctt?kn=23&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
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Signaling News
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WEB FOCUS: CANCER STEM CELLS
http://links.ealert.nature.com/ctt?kn=28&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
Cancer stem cells are defined as those cells within a tumor that can
self-renew and drive tumorigenesis. The cancer stem-cell concept has
important implications for cancer therapy. However, the generality
of the cancer stem-cell hypothesis has also been challenged.
This Nature web focus presents a selection of current research in
the field as well as a special pod cast.
More News
http://links.ealert.nature.com/ctt?kn=34&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - DECEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=17&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Neu5Gc: Consequences of dietary ingestion of non-human glycans
http://links.ealert.nature.com/ctt?kn=21&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
Modulating immune cell development: Polysialic acid sticks out
http://links.ealert.nature.com/ctt?kn=39&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=33&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
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Job of the Week
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Postdoctoral Research Fellows
Employer: Genentech
Location: South San Francisco, CA, USA
http://links.ealert.nature.com/ctt?kn=9&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
The Peter Jackson Lab/Cell Regulation lab at Genentech is currently
recruiting postdoctoral candidates at their facilities in South
San Francisco. These positions are open to study the regulation of
signaling through the primary cilium, cell cycle control, and
ubiquitin-proteasome pathways.
More Jobs:
http://links.ealert.nature.com/ctt?kn=2&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=19&m=30736099&r=MTQ4Nzg3MTk2NQS2&b=2&j=NDQxNDY5MTkS1&mt=1&rt=0
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