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World Stem Cell Summit 2010

Monday, December 1, 2008

Potentiating MSC by Serum Starvation

 

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Hello manoj kumar valluru,

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Last week an interesting paper was published describing how serum starvation of mesenchymal stem cells increases IGF-1 production by up to 200-fold.  This may be an easy method of potentiating therapeutic effects of MSC in existing experimental scenarios.  Perhaps more exciting was that the process of starvation was associated with epigenetic changes.

3 patents were issued of interest to our field.

The first one, #7,455,962, teaches how to isolate hemangioblasts by selection for a CD34-like molecule called podocalyxin-like protein 1 (PCLP-1).

The second patent, #7,455,983, covers methods of screening cultures of embryonic stem cells for media that can maintain the embryonic stem cells in an undifferentiated state, while allowing for their propagation.  This is one of the few "methods of screening" patents that we have come across.

The third patent, #7,456,333, discloses a transgenic mouse model of chronic myeloid leukemia (CML). This mouse has the leukemia-causing bcr-abl oncogene expressed selectively in cells positive for the stem cell antigen (SCA-1). The model resembles human CML pathology.  Too bad these sorts of patents cant be issued in Canada.

 

 


Method for preparing cell fraction containing hemangioblasts
 
 
Patent Number: 7,455,962

Therapeutic angiogenesis offers the possibility of treating a variety of diseases associated with ischemia.  For example, autologous bone marrow stem cells were used at Indiana University for the treatment of critical limb ischemia patients.  Although several studies have used various [Read More]

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  Stressed Mesenchymals Make More IGF-1

Sunday November 30th, 2008 @ 20:53:23 EST

New Orleans, Louisiana -

We at StemCellPatents.com have been stating for a while now that one of the future areas of our field will be not simply determining if stem cell therapies work, but how to optimize them.  For example, bone marrow derived MSC are already in Phase III clinical trials, and numerous...[Read More]

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Stem Cells World Congress

The Stem Cell Meeting 

RMSC 2008 World Congress (2-4 December 2008)
The 3rd Annual Stem Cells World Congress (20-22 January 2009)
The Stem Cell Meeting (March 2009)

 


  RECENTLY ADDED PATENTS  
  Transgenic non-human mammals as models for human pathologies of stem cell origin (7,456,333)
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  Medium for growing human embryonic stem cells (7,455,983)
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  Method for preparing cell fraction containing hemangioblasts (7,455,962)
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  Direct differentiation method for making cardiomyocytes from human embryonic stem cells (7,452,718)
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  Transluminal application of adult stem cells for body organ tissue repair (7,452,532)
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  Treatment of muscular dystrophy with cord blood cells (7,452,529)
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  Method of expanding and differentiating cord blood cells by hyperthermic incubation (7,452,662)
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  Methods and compositions for tissue regeneration (7,449,333)
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  Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies (7,449,186)
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  Compositions and methods for enrichment of neural stem cells using ceramide analogs (7,445,931)
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  View all 1361 Stem Cell Patents on StemCellPatents.com  


  LATEST NEWS  
  Stressed Mesenchymals Make More IGF-1
18 hours ago
 
  Fat Stem Cells Against Brain Damage
November 23rd
 
  Caloric Restriction Stimulates Angiogenesis Through Adiponectin
November 16th
 
  Mesenchymal Stem Cells Treating Pig Diabetes
November 4th
 
  Angiogenesis requires endogenous stem cells
November 3rd
 
  Read more news on StemCellPatents.com  


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E-mail: manojhind2001us@gmail.com
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