There are often two sides to a story in scientific research, yet the forum for debate can be limited. Outsiders who have developed their own ideas or methods may have trouble publishing in journals that set the tone for the field. EMBO reports hopes to open up debates in difficult fields of research and on topics of social relevance with its Talking Point articles. Find out more at http://links.ealert.nature.com/ctt?kn=11&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
The EMBO Journal
Table of contents
Volume 27, Number 24 (17 December 2008)
In this issue...
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P<SUB>2</SUB> in yeast and mouse
PI(3,5)P2 plays important roles in intracellular membrane trafficking ? in particular in retrograde trafficking from the late endosome/lysosome to the trans-Golgi network. Lois Weisman and colleagues now implicate Vac14 in its control, acting as a scaffold to bring together and organise a large protein complex required for the regulation of PI(3,5)P2 metabolism.
http://links.ealert.nature.com/ctt?kn=58&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Control of WHITE COLLAR localization by phosphorylation is a critical step in the circadian negative feedback process
Yi Liu and colleagues identify protein phosphatase 4 as a novel key component of the Neurospora circadian oscillator, and show the localization of the circadian transcriptional activator, the WHITE COLLAR complex, to be regulated by an interplay of kinases and phosphatases.
http://links.ealert.nature.com/ctt?kn=53&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Articles
VAC14 nucleates a protein complex essential for the acute
interconversion of PI3P and PI(3,5)P2 in yeast and mouse.
Natsuko Jin, Clement Y Chow, Li Liu, Sergey N Zolov, Roderick
Bronson, Muriel Davisson, Jason L Petersen, Yanling Zhang, Sujin
Park, Jason E Duex, Daniel Goldowitz, Miriam H Meisler and Lois S
Weisman
The EMBO Journal (2008) 27, 24, 3221-3234
http://links.ealert.nature.com/ctt?kn=58&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 27 November 2008
Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome
separation during bipolar spindle assembly.
Marvin E Tanenbaum, Libor Macurek, Niels Galjart and René H Medema
The EMBO Journal (2008) 27, 24, 3235-3245
http://links.ealert.nature.com/ctt?kn=49&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 20 November 2008
Control of WHITE COLLAR localization by phosphorylation is a critical
step in the circadian negative feedback process.
Joonseok Cha, Shwu-Shin Chang, Guocun Huang, Ping Cheng and Yi Liu
The EMBO Journal (2008) 27, 24, 3246-3255
http://links.ealert.nature.com/ctt?kn=53&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 20 November 2008
Mammalian Elongin A complex mediates DNA-damage-induced
ubiquitylation and degradation of Rpb1.
Takashi Yasukawa, Takumi Kamura, Shigetaka Kitajima, Ronald C
Conaway, Joan W Conaway and Teijiro Aso
The EMBO Journal (2008) 27, 24, 3256-3266
http://links.ealert.nature.com/ctt?kn=34&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 27 November 2008
Common thiolation mechanism in the biosynthesis of tRNA thiouridine
and sulphur-containing cofactors.
Naoki Shigi, Yuriko Sakaguchi, Shin-ichi Asai, Tsutomu Suzuki and
Kimitsuna Watanabe
The EMBO Journal (2008) 27, 24, 3267-3278
http://links.ealert.nature.com/ctt?kn=63&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 27 November 2008
Impediment of E. coli UvrD by DNA-destabilizing force reveals a
strained-inchworm mechanism of DNA unwinding.
Bo Sun, Kong-Ji Wei, Bo Zhang, Xing-Hua Zhang, Shuo-Xing Dou, Ming Li
and Xu Guang Xi
The EMBO Journal (2008) 27, 24, 3279-3287
http://links.ealert.nature.com/ctt?kn=17&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 13 November 2008
A synaptic DEG/ENaC ion channel mediates learning in C. elegans by
facilitating dopamine signalling.
Giannis Voglis and Nektarios Tavernarakis
The EMBO Journal (2008) 27, 24, 3288-3299
http://links.ealert.nature.com/ctt?kn=10&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 27 November 2008
microRNA-122 stimulates translation of hepatitis C virus RNA.
Jura Inga Henke, Dagmar Goergen, Junfeng Zheng, Yutong Song,
Christian G Schüttler, Carmen Fehr, Christiane Jünemann and Michael
Niepmann
The EMBO Journal (2008) 27, 24, 3300-3310
http://links.ealert.nature.com/ctt?kn=64&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 20 November 2008
Interferon-inducible protein, P56, inhibits HPV DNA replication by
binding to the viral protein E1.
Fulvia Terenzi, Paramananda Saikia and Ganes C Sen
The EMBO Journal (2008) 27, 24, 3311-3321
http://links.ealert.nature.com/ctt?kn=13&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 13 November 2008
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed
by cryo-EM.
Wen Li, Xabier Agirrezabala, Jianlin Lei, Lamine Bouakaz, Julie L
Brunelle, Rodrigo F Ortiz-Meoz, Rachel Green, Suparna Sanyal, Mans
Ehrenberg and Joachim Frank
The EMBO Journal (2008) 27, 24, 3322-3331
http://links.ealert.nature.com/ctt?kn=29&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Published online: 20 November 2008
Corrigenda
EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane
curvature-dependent actin polymerization.
Kazunori Takano, Kiminori Toyooka and Shiro Suetsugu
The EMBO Journal (2008) 27, 24, 3332
http://links.ealert.nature.com/ctt?kn=38&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in
postnatal neuronal migration.
Sophia M Blake, Vera Strasser, Nuno Andrade, Sarah Duit, Reinhold
Hofbauer, Wolfgang J Schneider and Johannes Nimpf
The EMBO Journal (2008) 27, 24, 3332
http://links.ealert.nature.com/ctt?kn=28&m=30713313&r=MTQ1Nzc1OTA4OQS2&b=2&j=NDQwNTY0OTUS1&mt=1&rt=0
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