Signaling Gateway - 28 November 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0M40EW
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
ESTROGEN SIGNALING: ERBB2 HANGS IN THE BALANCE
The sensitivity of breast cancer tumors to tamoxifen depends upon
the inhibition and activation of ERBB2 gene expression, which is
controlled by the competitive binding of PAX2 and AIB-1 to a
cis-regulatory element.
Original research paper: Nature advance online publication,
12 November 2008 (DOI 10.1038/nature07483)
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0vP0Ef
------------------------
Molecule Pages
------------------------
The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Lcmt2
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoQ0En
Leucine carboxyl methyltransferase-2 (LCMT-2) is a homolog of LCMT-1,
which catalyzes reversible carboxyl methylation of protein
phosphatase 2A (PP2A). Although LCMT-2 is highly similar to LCMT-1,
existing data from yeast studies suggest that LCMT-2 may not be a
PP2A methyltransferase. The yeast homolog of LCMT-2 was recently
shown to be involved in the biosynthesis of wybutosine, a modified
nucleoside in yeast phenylalanine tRNA.
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0BUuz0Er
-------------------
Selected Updates
-------------------
CALCIUM: AN EFFECTIVE GET-TOGETHER
The ER transmembrane protein STIM1 (stromal interaction molecule-1)
assembles and opens the ORAI1 tetrameric ion channel.
Original research paper: Nature 456, 116-120 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoR0Eo
LIPID METABOLISM: TREASURE HUNT IN FAT
The adipose tissue-derived hormone palmitoleate enhances insulin
signaling in muscle cell lines by inducing insulin-stimulated AKT
phosphorylation, and suppresses inflammatory alterations in adipose
tissue.
Original research paper: Cell 134, 933-944 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoS0Ep
TUMORIGENESIS: KEEPING A WATCHFUL EYE
Loss of IKKalpha (inhibitor of nuclear factor kappaB kinase-alpha)
upregulates EGFR signaling and contributes to the development of
squamous cell carcinoma (SCC) of the skin.
Original research paper: Cancer Cell 14, 212-225 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoT0Eq
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0vO0Ee
------------------------
Research Library
------------------------
SCAFFOLDING FUNCTION OF PAK IN THE PDK1-AKT PATHWAY
Nature Cell Biology 10, 1356-1364 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoU0Er
THE miR-15A-miR-16-1 CLUSTER CONTROLS PROSTATE CANCER BY TARGETING
MULTIPLE ONCOGENIC ACTIVITIES
Nature Medicine 14, 1271-1277 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoV0Es
A QUANTITATIVE MODEL OF TRANSCRIPTION FACTOR-ACTIVATED GENE
EXPRESSION
Nature Structural and Molecular Biology 15, 1192-1198 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoW0Et
------------------------
Signaling News
------------------------
UCSD-NATURE MOLECULE PAGES: GETTING STARTED GUIDE
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CBVN0EK
The UCSD-Nature Molecule Pages contain over 500 peer-reviewed and
published review articles about the biological and biochemical
properties of signaling proteins from transcription factors to
membrane receptors. Please visit our new getting started guide for
a quick overview of the anatomy of a published Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CBVN0EK
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0Crw0EN
-------------------------
Gateway Updates
-------------------------
RNAi GATEWAY
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CALQ0EC
From humble beginnings as an obscure phenomenon in plants, RNA
interference (RNAi) has evolved into an area that has a significant
impact on numerous fields. The RNAi Gateway provides a convenient
portal into Nature Publishing Group publications relevant to every
aspect of RNAi.
The gateway features a podcast and a library of relevant reviews and
articles organized by date, subject and organism.
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoX0Eu
-----------------------------
Signaling Job of the Week
-----------------------------
Full professorship positions
Employer: Friedrich Schiller University Jena
Location: Jena, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0CCoY0Ev
The Faculty of Biology and Pharmacy of the Friedrich Schiller
University of Jena invites applications for two full professorships
at the Institute of Nutrition. The successful candidates will use
cutting-edge bio-analytical techniques to pursue research in the
metabolism of physiological and toxicological compounds, or in the
regulation of signaling cascades and transcription by metabolites.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0BnjC0EC
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0vqs0E8
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0dIO0EZ
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0BCGZ0EH
For further technical assistance or any other enquiries, please click here:
http://ealerts.nature.com/cgi-bin24/DM/y/eo7Y0Xztnp0H2W0mg0Et
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2008 Nature Publishing Group
---------------------------------------------------------------------
