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| New Volume/Issue is now available on ScienceDirect |
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| Leading Edge |
| 1. | In This Issue Pages 765, 767 |
| 2. | Molecular Biology Select Pages 769, 771 |
| Essay |
| 3. | Microscopes for Fluorimeters: The Era of Single Molecule Measurements Pages 779-785 Ronald D. Vale |
| Previews |
| 4. | Lighting Up the Stressed ER Pages 787-789 Sang-Wook Kang, Ramanujan S. Hegde |
| 5. | Evolution in a Test Tube: The Hatchet before the Scalpel Pages 789-791 Oliver J. Rando |
| 6. | Organizing Junctions at the Cell-Cell Interface Pages 791-793 Anna Akhmanova, Alpha S. Yap |
| 7. | RNAi Delivers Insights into Liver Cancer Pages 793-795 René Bernards |
| 8. | When the Gut Talks to Bone Pages 795-796 Fanxin Long |
| 9. | Aging: A Sirtuin Shake-Up? Pages 797-798 Jan Vijg, Alexander Y. Maslov, Yousin Suh |
| Review |
| 10. | Polarity and Differential Inheritance—Universal Attributes of Life? Pages 801-812 Ian G. Macara, Stavroula Mili |
| Articles |
| 11. | N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake Pages 813-824 Matthew P. Gillum, Dongyan Zhang, Xian-Man Zhang, Derek M. Erion, Rachel A. Jamison, Cheolsoo Choi, Jianying Dong, Marya Shanabrough, Hillary R. Duenas, David W. Frederick, Jennifer J. Hsiao, Tamas L. Horvath, Chun Min Lo, Pat Tso, Gary W. Cline, Gerald I. Shulman |
| 12. | Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum Pages 825-837 Vijay K. Yadav, Je-Hwang Ryu, Nina Suda, Kenji F. Tanaka, Jay A. Gingrich, Günther Schütz, Francis H. Glorieux, Cherie Y. Chiang, Jeffrey D. Zajac, Karl L. Insogna, J. John Mann, Rene Hen, Patricia Ducy, Gerard Karsenty |
| 13. | Motor Deficit in a Drosophila Model of Mucolipidosis Type IV due to Defective Clearance of Apoptotic Cells Pages 838-851 Kartik Venkatachalam, A. Ashleigh Long, Rebecca Elsaesser, Daria Nikolaeva, Kendal Broadie, Craig Montell |
| 14. | An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer Pages 852-864 Lars Zender, Wen Xue, Johannes Zuber, Camile P. Semighini, Alexander Krasnitz, Beicong Ma, Peggy Zender, Stefan Kubicka, John M. Luk, Peter Schirmacher, W. Richard McCombie, Michael Wigler, James Hicks, Gregory J. Hannon, Scott Powers, Scott W. Lowe |
| 15. | Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma Pages 865-878 Lixing Zhan, Avi Rosenberg, Kenneth C. Bergami, Min Yu, Zhenyu Xuan, Aron B. Jaffe, Craig Allred, Senthil K. Muthuswamy |
| 16. | Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor Pages 879-893 Giulia Rancati, Norman Pavelka, Brian Fleharty, Aaron Noll, Rhonda Trimble, Kendra Walton, Anoja Perera, Karen Staehling-Hampton, Chris W. Seidel, Rong Li |
| 17. | Chromosome Congression by Kinesin-5 Motor-Mediated Disassembly of Longer Kinetochore Microtubules Pages 894-906 Melissa K. Gardner, David C. Bouck, Leocadia V. Paliulis, Janet B. Meehl, Eileen T. O'Toole, Julian Haase, Adelheid Soubry, Ajit P. Joglekar, Mark Winey, Edward D. Salmon, Kerry Bloom, David J. Odde |
| 18. | SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging Pages 907-918 Philipp Oberdoerffer, Shaday Michan, Michael McVay, Raul Mostoslavsky, James Vann, Sang-Kyu Park, Andrea Hartlerode, Judith Stegmuller, Angela Hafner, Patrick Loerch, Sarah M. Wright, Kevin D. Mills, Azad Bonni, Bruce A. Yankner, Ralph Scully, Tomas A. Prolla, Frederick W. Alt, David A. Sinclair |
| 19. | 3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA Pages 919-932 Jeremy E. Wilusz, Susan M. Freier, David L. Spector |
| 20. | Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions Pages 933-947 Philip I. Merksamer, Ala Trusina, Feroz R. Papa |
| 21. | Anchorage of Microtubule Minus Ends to Adherens Junctions Regulates Epithelial Cell-Cell Contacts Pages 948-959 Wenxiang Meng, Yoshimi Mushika, Tetsuo Ichii, Masatoshi Takeichi |
| 22. | A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex Pages 960-973 Sathyanarayanan V. Puthanveettil, Francisco J. Monje, Maria Concetta Miniaci, Yun-Beom Choi, Kevin A. Karl, Eugene Khandros, Mary Ann Gawinowicz, Michael P. Sheetz, Eric R. Kandel |
| SnapShot |
| 23. | SnapShot: Cell-Cycle Regulators II Pages 974-974.e1 David O. Morgan |
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