Signaling Gateway - 21 November 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0M40E5
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TOLL-LIKE RECEPTORS: LESS IS MORE
Proteolytic cleavage of the Toll-like receptor TLR9 creates a
functional receptor that is retained at intracellular endolysosome
compartments.
Original research paper: Nature advance online publication,
28 September 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0vP0EF
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Selected Updates
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GENE EXPRESSION: COMING IN WAVES
Transcription of calcineurin-responsive zinc-finger (Crz1) target
genes is regulated by the frequency of rapid, synchronized bursts
of Crz1 nuclear localization.
Original research paper: Nature 455, 485-490 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0CCCe0Ex
RADIOTHERAPY: WORMING YOUR WAY TO CELL DEATH
Exposure to ionizing radiation stimulates the C. elegans
p53-dependent and ceramide biosynthesis pathways to activate core
mitochondrial apoptotic machinery.
Original research paper: Science 322, 110-115 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0CCCf0Ey
IMMUNOLOGY: AN UNEXPECTED COMPLEMENT
The activation of complement signaling pathways in myeloid-derived
suppressor cells (MDSCs) contributes to tumor growth by inhibiting
the recruitment of tumor-infiltrating CD8+ T cells.
Original research paper: Nature Immunol. 9, 1225-1235 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0CCCg0Ez
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0vO0EE
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Research Library
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CALCIUM-BOUND STRUCTURE OF CALPAIN AND ITS MECHANISM OF INHIBITION
BY CALPASTATIN
Nature 456, 409-412 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0CCCh0E1
IAPs CONTAIN AN EVOLUTIONARILY CONSERVED UBIQUITIN-BINDING DOMAIN
THAT REGULATES NF-[KAPPA]B AS WELL AS CELL SURVIVAL AND ONCOGENESIS
Nature Cell Biology 10, 1309-1317 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0CCCi0E2
HIGH-SPEED, MINIATURIZED FLUORESCENCE MICROSCOPY IN FREELY MOVING
MICE
Nature Methods 5, 935-938 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0CCCj0E3
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Signaling News
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NATURE REVIEWS CANCER ARTICLE SERIES: RB AND E2F
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0B3ud0EV
The retinoblastoma (RB) tumor suppressor protein is famous for
regulating the G1 phase of the cell cycle by suppressing the function
of the E2F family of transcription factors. Nature Reviews Cancer has
commissioned a short series of articles that discuss some of recent
findings about RB function, including a FREE review entitled
"Cellular mechanisms of tumour suppression by the retinoblastoma
gene" by Deborah L. Burkhart and Julien Sage.
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0B3uR0ED
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0Crw0Ev
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Gateway Updates
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HOPPING ACROSS THE GENOME
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0CCCk0E4
Information Hyperlinked Over Proteins (iHOP) creates a
literature-based, contextual network of genes and proteins
from thousands of different organisms. In addition to displaying
interactive sentences from PubMed abstracts that reference your
protein of interest, iHOP also provides links to important publicly
available databases, including the NCI-Nature Pathway Interaction
Database.
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0BGyx0EF
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Signaling Job of the Week
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PhD Scholars Programme in Cancer Biology
Employer: University College Cork
Location: Cork, Ireland
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0CCCl0E5
The PhD Scholars Programme in Cancer Biology at University College
Cork, Ireland invites applications for the 2009 academic year.
The program focuses on cell signaling systems and gene regulation
in cancer. Following three laboratory rotations and coursework, each
Scholar will undertake a research project that will lead to the
award of the PhD.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0BnjC0Ek
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eoyu0Xztnp0H2W0vqs0Eh
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