December 2008 Volume 9 Number 12
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Nature Milestones in Cytoskeleton
A collaboration from Nature, Nature Cell Biology
and Nature Reviews Molecular Cell Biology, this
supplement focuses on the pivotal breakthroughs
in cytoskeleton research over the past 60 years.
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This month's FEATURED article:
Translational control of localized mRNAs: restricting protein
synthesis in space and time
Florence Besse and Anne Ephrussi
p971 | doi:10.1038/nrm2548
http://links.ealert.nature.com/ctt?kn=47&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
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From the editors
p917 | doi:10.1038/nrm2591
http://links.ealert.nature.com/ctt?kn=24&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Endocytosis: The importance of ART in trafficking
p919 | doi:10.1038/nrm2590
http://links.ealert.nature.com/ctt?kn=51&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Mechanisms of disease: Supporting stability
p920 | doi:10.1038/nrm2544
http://links.ealert.nature.com/ctt?kn=16&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Cancer biology: Another string to the bow
p920 | doi:10.1038/nrm2587
http://links.ealert.nature.com/ctt?kn=20&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Chromatin: Chopping the ends
p921 | doi:10.1038/nrm2588
http://links.ealert.nature.com/ctt?kn=49&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Protein translocation: Surfing the channel
p922 | doi:10.1038/nrm2547
http://links.ealert.nature.com/ctt?kn=70&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Cell signalling: Range over strength
p922 | doi:10.1038/nrm2551
http://links.ealert.nature.com/ctt?kn=27&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Protein stability: GPS for proteomes
p922 | doi:10.1038/nrm2554
http://links.ealert.nature.com/ctt?kn=61&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
IN BRIEF
Cell adhesion | Cytoskeleton | DNA repair
p923 | doi:10.1038/nrm2555
http://links.ealert.nature.com/ctt?kn=90&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Development: Dogma overturned
p924 | doi:10.1038/nrm2545
http://links.ealert.nature.com/ctt?kn=67&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
TECHNOLOGY WATCH
Developmental blueprint | Computing RNA devices
p924 | doi:10.1038/nrm2553
http://links.ealert.nature.com/ctt?kn=52&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
AN INTERVIEW WITH...
Matthew Meselson
p926 | doi:10.1038/nrm2552
http://links.ealert.nature.com/ctt?kn=93&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Corrigendum: Ataxia-telangiectasia: from a rare disorder to a
paradigm for cell signalling and cancer
Martin F. Lavin
p927 | doi:10.1038/nrm2598
http://links.ealert.nature.com/ctt?kn=58&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
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REVIEWS
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Fluorescent probes for super-resolution imaging in living cells
Marta Fernandez-Suarez and Alice Y. Ting
p929 | doi:10.1038/nrm2531
Recent advances in fluorescent probe technology have improved spatial
and temporal resolution, bringing us closer to the ideal of imaging
individual cellular features in real time with molecular (1-5 nm)
resolution. In parallel, the development of super-resolution imaging
techniques has revolutionized fluorescence microscopy.
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
One step at a time: endoplasmic reticulum-associated degradation
Shruthi S. Vembar and Jeffrey L. Brodsky
p944 | doi:10.1038/nrm2546
The quality control process ERAD, endoplasmic reticulum (ER)-associated
degradation, results in the removal of aberrant secreted proteins from
the ER. Molecular chaperones and associated factors recognize and target
substrates for retrotranslocation to the cytoplasm, where they are
degraded by the ubiquitin-proteasome machinery.
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Transcription-coupled DNA repair: two decades of progress and surprises
Philip C. Hanawalt and Graciela Spivak
p958 | doi:10.1038/nrm2549
Transcribed genes are scanned by RNA polymerases, which can detect
DNA damage and initiate the transcription-coupled repair (TCR) pathway.
Understanding the clinical features and genetic deficiencies of human
hereditary diseases that exhibit TCR defects will help to elucidate
the mechanism of TCR in eukaryotes.
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Translational control of localized mRNAs: restricting protein synthesis
in space and time
Florence Besse and Anne Ephrussi
p971 | doi:10.1038/nrm2548
The localization of mRNAs coupled with precise translational control
is an important mechanism that is used by cells to establish
functionally distinct compartments. Translation of localizing mRNAs
is repressed by mechanisms that target translation initiation, and
is derepressed following arrival at the final destination.
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Design principles of biochemical oscillators
Bela Novak and John J. Tyson
p981 | doi:10.1038/nrm2530
Biochemical oscillations are generated by complex interactions between
genes, proteins and cellular metabolites and underlie many processes.
Oscillatory behaviour is characterized by negative feedback with time delay,
nonlinearity of the reaction kinetics and proper balancing of the
timescales of opposing chemical reactions.
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
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PERSPECTIVES
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SCIENCE AND SOCIETY
Stem cells: US policies on human embryonic stem cells
Richard O. Hynes
p993 | doi:10.1038/nrm2528
In the absence of federal regulations, guidelines for human embryonic
stem-cell research in the United States have been developed by independent
scientific organizations. These guidelines ensure the ethical conduct
of stem-cell research and serve as a template for the development of
individual states' legislations.
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
SCIENCE AND SOCIETY
The regulation of human embryo and stem-cell research in the United Kingdom
Robin Lovell-Badge
p998 | doi:10.1038/nrm2550
The 1990 Human Fertilisation and Embryology (HFE) Act and its amendments
regulate the derivation of human embryonic stem cells in the United Kingdom.
A new bill, which has just passed through Parliament, will have important
consequences for research in embryos and stem cells.
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
OPINION
Autophagic cell death: the story of a misnomer
Guido Kroemer and Beth Levine
p1004 | doi:10.1038/nrm2529
The question of whether cell death can occur by autophagy cannot yet be
answered definitively, although the occurrence of cell death with autophagy
is common. The term autophagic cell death should therefore be considered
a misnomer until this issue has been resolved.
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=30614402&r=MTI5NzQ2Njg4NQS2&b=2&j=NDMyMjQ2MDgS1&mt=1&rt=0
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