Signaling Gateway - 14 November 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0M40Ew
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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STRESS SIGNALING: STRESS GRANULES RACK1 UP MTK1
Stress granule formation inhibits apoptosis by suppressing
stress-responsive MAPK pathways and sequestering the scaffold
protein RACK1.
Original research paper: Nature Cell Biology 10, 1324-1332 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0vP0E6
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
500 Molecule Pages Published!
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVN0Ek
We are pleased to announce the publication of HB-EGF, our 500th
Molecule Page. Each week, we publish several of these concise, free
review articles on a diverse range of signaling molecules, from
transcription factors to membrane receptors. In addition to these
published pages, the Molecule Pages database also includes key
information about the biological, biochemical and functional
activities of thousands of signaling molecules. Please see our new
getting started guide for a quick overview of the anatomy of a
Molecule Page.
HB-EGF
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVO0El
HB-EGF is a member of the EGF family of growth factors that binds to
and activates EGF receptor (EGFR) and ErbB4. HB-EGF has been
implicated in several physiological and pathological processes in
mice, including heart muscle homeostasis, heart valve development,
eyelid closure, skin wound healing, skin hyperplasia, lung
development, blastocyst implantation and tumorigenesis.
Also published this week: Pak1
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVP0Em
Itpk1
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBZ50EP
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0BUuz0EJ
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Selected Updates
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TUMORIGENESIS: IT'S A KNOCKOUT!
Knocking out the p53 homolog TAp73 has revealed a role for the
protein in tumor suppression and the maintenance of genomic
integrity.
Original research paper: Genes Dev. 22, 2677-2691 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVQ0En
NEURODEGENERATIVE DISEASE: NEW WAYS OF TACKLING ABETA TOXICITY
Two studies reveal an important function for amyloid-beta (Abeta)
peptides in the pathogenesis of Alzheimer's disease and suggest a
novel therapeutic approach to tackle Abeta's deleterious effects.
Original research paper: Nature Med. 14, 1097-1105 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVR0Eo
PROTEIN BIOCHEMISTRY: EVOLVING A BETTER-EXPRESSING GPCR
A directed evolution approach has been successful in designing G
protein-coupled receptors (GPCRs) with greater stability and enhanced
expression.
Original research paper: Proc. Natl. Acad. Sci. USA 105,
14808-14813 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVS0Ep
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0vO0E5
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Research Library
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CEACAM1 INHIBITS TOLL-LIKE RECEPTOR 2-TRIGGERED ANTIBACTERIAL
RESPONSES OF HUMAN PULMONARY EPITHELIAL CELLS
Nature Immunology 9, 1270-1278 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVT0Eq
SUPPRESSED NFAT-DEPENDENT VEGFR1 EXPRESSION AND CONSTITUTIVE VEGFR2
SIGNALING IN INFANTILE HEMANGIOMA
Nature Medicine 14, 1236-1246 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVU0Er
THE H3K36 DEMETHYLASE JHDM1B/KDM2B REGULATES CELL PROLIFERATION AND
SENESCENCE THROUGH p15INK4B
Nature Structural & Molecular Biology 15, 1169-1175 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVV0Es
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - NOVEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0BGyx0E6
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
Recent updates to the database include:
Plasma membrane estrogen receptor signaling events
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVW0Et
Glypican pathway
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVX0Eu
Sign up here to receive the monthly update alert for the NCI-Nature
Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0BJYy0Ed
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Signaling Job of the Week
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Postdoctoral Molecular Biologist
Employer: University of Sydney
Location: Sydney, Australia
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0CBVY0Ev
A postdoctoral position is available at the Pharmacogenomics and Drug
Development Group at the University of Sydney. The successful
applicant will research the transcriptional regulation and function
of human CYP genes and their allelic variants in apoptosis and cell
survival. The project may lead to the development of combined drug
and nutritional therapies to prevent cancer and improve
cardiovascular function.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0BnjC0Ec
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0vqs0EZ
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http://ealerts.nature.com/cgi-bin24/DM/y/eopv0Xztnp0H2W0dIO0Ez
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