Signaling Gateway - 31 October 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0M40EZ
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TYROSINE KINASES: AN ABL GATEKEEPER
Mutation of a threonine near the active site of tyrosine kinases
leads to persistent kinase activation and drug resistance.
Original research paper: Nature Structural & Molecular Biology 15,
1109-1118 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0vP0Ei
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
PCAF lysine acetyltransferase
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKW0EK
PCAF is a nuclear lysine acetyltransferase that acetylates lysine 14
of histone H3 and lysines 8 and 16 of histone H4, in addition to many
transcription factors and several cytosolic proteins. Despite its
ubiquitous expression, PCAF knockout mice show only a mild phenotype,
including deficits in long-term memory and an exaggerated response to
acute stress, forced swimming and conditioned fear.
Also published this week:
MOZ lysine acetyltransferase
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKX0EL
MORF lysine acetyltranferase
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKY0EM
Vangl2
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKZ0EN
Arf-like protein 6
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKa0EU
Arf-like protein 4C
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKb0EV
Plasma membrane calcium transporting ATPase isoform 4
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKc0EW
5-Hydroxytryptamine receptor 2C
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKd0EX
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BUuz0Eu
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Selected Updates
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MEMBRANE TRAFFICKING: ENDURANCE OF THE WEAKEST SIGNAL
Strongly activated STAT3 diffuses from the cytoplasm into the
nucleus, whereas weakly activated STAT3 is shepherded to the nucleus
by a microtubule-dependent process.
Original research paper: J. Cell Biol. 182, 855-863 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKe0EY
GENETICS: MORE THAN ONE WAY....
Unbiased, systematic approaches to cataloging the genetic alterations
in cancer should lead to a comprehensive understanding of the changes
that occur during tumor development and treatment.
Original research paper: Nature 455, 1061-1068 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKf0EZ
TRANSCRIPTOMICS: THERE'S NOTHING ABNORMAL ABOUT CHIMERIC RNA
Trans-splicing of individual mRNAs resulting in the fusion of the
first 3 exons of JAZF1 to the last 15 exons of JJAZ1 has been
detected in endometrial cancers, but may also play a role in
protecting normal endometrial cells from apoptosis.
Original research paper: Science 321, 1357-1361 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKg0Ea
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0vO0Eh
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Research Library
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GLYCOGEN SYNTHASE KINASE 3 IN MLL LEUKAEMIA MAINTENANCE AND TARGETED
THERAPY
Nature 455, 1205-1209 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKh0Eb
PROOF-BY-SYNTHESIS OF THE TRANSCRIPTIONAL LOGIC OF MAMMALIAN
CIRCADIAN CLOCKS
Nature Cell Biology 10, 1154-1163 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKi0Ec
A SODIUM-MEDIATED STRUCTURAL SWITCH THAT CONTROLS THE SENSITIVITY OF
KIR CHANNELS TO PtdIns(4,5)P2
Nature Chemical Biology 4, 624-631 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKj0Ed
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Signaling News
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NATURE AWARDS FOR MENTORING IN SCIENCE – GERMANY
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BsoK0EX
The winners of the annual Nature Awards for Mentoring in Science have
been announced. The 2008 awards invited nominations from Germany,
with two prizes of €10,000 - one for a mid-career scientist and one
for lifetime achievement. Klass Bergmann of the Technical University
of Kaiserslautern and Heinrich Betz, director of the Max Planck
Institute for Brain Research, Frankfurt share the lifetime
achievement award. Peer Bork of the European Molecular Biology
Laboratory, Heidelberg won the mid-career achievement award.
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0Btvx0EQ
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0Crw0EQ
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - OCTOBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BKHW0EQ
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Bacterial glycans and mammalian lectins: A precarious balance
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0B7XP0EF
Protein O-glycosylation: Drosophila on acid
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0B7XQ0EG
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BJYw0EE
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Signaling Job of the Week
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Postdoctoral position
Employer: Cancer Research Center of Salamanca
Location: Salamanca, Spain
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKk0Ee
A postdoctoral position is available in the laboratory of
Dr. Xosé Bustelo at the Centro de Investigacion del Cancer
(Cancer Research Center) of Salamanca, Spain. Studies in the
laboratory focus on the functional characterization of Ras/Rho
superfamily GTPases and their regulators. The successful applicant
will study the cytoskeletal regulators involved in cancer and other
diseases.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BnjC0EF
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0vqs0EC
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http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0dIO0Ec
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