Sensitizing Leukemic Cells to GVL

View this message online Hello manoj kumar valluru, Last week a paper was published describing that treated with the proteosome inhibitor Velcade could actually sensitize quiescent CML progenitors to killing by natural killer cells.  This is important since CML is one of the situations where immunological control of cancer has been well documented. Two patents in the area of stem cells were issued last week.  # 7,435,718 discloses compositions of matter for antagonizing CXCR4 and # 7,435,592 covers T cells activated with anti-CD3 and anti-CD28 !  No joke !  this patent could be very useful given that anti-CD3 and anti-CD28 are the main ways of activating human T cells.   Compositions for allogeneic cell therapy     Patent Number: 7,435,592 Assignee | Inventor This patent covers a composition of activated T cells, either autologous or allogeneic.  It is very interesting since the way the claims issued, it covers pretty much any T cell that has been activated by ligation of CD3 and CD28 (the most common way of activating T cell cells).  The first independent claim covers a...[Read More] Ask a question OR leave your comments.     Sensitizing CML Precursors to GVL Sunday October 19th, 2008 @ 12:42:24 EST Bethesda, Maryland - Chronic myeloid leukemia (CML) is a cancer of the myeloid committed stem cell, which is caused primarily by the oncogenic chimeric protein BCR-ABL.  Immune responses are known to control progression of CML.  For example, patients with CML taking interferon that have higher NK cell...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News       RMSC 2008 World Congress (2-4 December 2008) The 3rd Annual Stem Cells World Congress (20-22 January 2009) The Stem Cell Meeting (March 2009)     RECENTLY ADDED PATENTS     Compositions for allogeneic cell therapy (7,435,592) Assignee | Inventor | Ask a question OR leave your comments     CXCR4 antagonist treatment of hematopoietic cells (7,435,718) Assignee | Inventor | Ask a question OR leave your comments     Methods for the culture of human embryonic stem cells on human feeder cells (7,432,104) Assignee | Inventor | Ask a question OR leave your comments     Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions (7,431,932) Assignee | Inventor | Ask a question OR leave your comments     Vasostatin as marrow protectant (7,432,236) Assignee | Inventor | Ask a question OR leave your comments     Unactivated oocytes as cytoplast recipients for nonprimate mammalian and pig nuclear transfer (7,432,415) Assignee | Inventor | Ask a question OR leave your comments     Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion (7,429,383) Assignee | Inventor | Ask a question OR leave your comments     Methods of controlling proliferation and differentiation of stem and progenitor cells (7,429,489) Assignee | Inventor | Ask a question OR leave your comments     Methods of cancer diagnosis and therapy targeted against a cancer stem line (7,427,400) Assignee | Inventor | Ask a question OR leave your comments     Methods for identifying stem cells based on nuclear morphotypes (7,427,502) Assignee | Inventor | Ask a question OR leave your comments     View all 1345 Stem Cell Patents on StemCellPatents.com     LATEST NEWS     Sensitizing CML Precursors to GVL 1 day ago     Making stem cells find apoptotic cells October 8th     ES cells as immune modulators: look out MSCs !! October 5th     Cancer Vaccine Against Aurora Kinase October 2nd     Selecting for better mesenchymal stem cells September 27th     Read more news on StemCellPatents.com     LATEST JOBS POSTS     Attorney- Patent Litigation Associate Crescent Strategic Resources     View the StemCellPatents.com Job Board   Thanks again for your help in supporting StemCellPatents.com. We welcome your comments and suggestions! Tell us here. Media Partnerships (NEW) ------------------------------------------------------------ To unsubscribe, click here. Delivered: Monday October 20th, 2008 @ 15:15:08 EST