October 16 2008
Visit Nature Reports Stem Cells online.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0BU280Ef
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TOP STORIES
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Pluripotent caricatures
McMaster University's Mickie Bhatia argues that cells derived from embryonic stem cells in culture may be only 'cartoon' versions of the real thing, but that doesn't mean they are not useful
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Ik0EQ
Persistence pays off
Stem cell researchers say that favourable policy in the United Kingdom is the result of taking the time to win over legislators
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B7Lv0Ed
Cell therapy: Being patient
Cell therapies are as much about the patients as they are about the cells
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B6vL0Ec
What stem cell therapy can learn from gene therapy
Some bioethicists see history repeating itself
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Il0ER
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RESEARCH HIGHLIGHTS AND NEWS STORIES KEYING OFF RECENT PUBLICATIONS:
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New routes to pluripotency
Human testis cells become pluripotent in culture
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Im0ES
Conrad, S. et al. Nature advance online publication, doi:10.1038/nature07404 (8 October 2008).
Cell 'rebooting' technique sidesteps risks
Virus reprograms cells without disrupting genome
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B6mY0Eg
Stadtfeld, M. et al. Science doi:10.1126/science.1162494 (published online 25 September 2008).
Corneal stem cells, no exceptions
Stem cells spread throughout the corneal surface repair general wear and tear
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8In0ET
Majo, F. et al. Nature advance online publication, doi:10.1038/nature07406 (1 October 2006).
Location, location, location
Neural stem cells can adopt an alternative cell fate if placed in the mammary microenvironment
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Io0EU
Booth, B. W. et al. Proc. Natl Acad. Sci. USA 105, 14891-14896 (2008).
PTEN out of ten for planarians
Planaria as a model system to study PTEN in adult tissue homeostasis
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Ip0EV
Oviedo, N. et al. Dis. Models Mech. doi:10.1242/dmm.000117 (published online 1 September 2008).
Strong as blood
Two studies show blood vessels host a supply of cells essential to regeneration
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Iq0EW
Tang, W. et al. Science doi:10.1126/science.1156232 (published online 18 September 2008).
Crisan, M. Cell Stem Cell 3, 301-313 (2008).
Versatile microRNAs, two-faced transcription factors and embryonic stem cells
Two studies describe the sophistication within the gene regulation systems of stem cells
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Ir0EX
Tay, Y., Zhang, J., Thomson, A., Lim, B. & Rigoutsos, I. Nature advance online publication, doi:10.1038/nature07299 (21 September 2008).
Lim, B. et al. Cell Stem Cell doi:10.1016/j.stem.2008.08.004 (published online 18 September 2008).
Plasticity of the pluripotent
Two genes modulate commitment of embryonic cells to embryo proper or outer tissues
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Is0EY
Hayashi, K. et al. Cell Stem Cell 3, 391-401 (2008).
Ng, R.K. et al. Nat. Cell Biol. advanced online publication, doi:10.1038/ncb1786 (5 October 2008).
Integration-free iPS cells
Reprogramming does not require permanent genetic modification
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8It0EZ
Stadtfield, M. et al. Science doi:10.1126/science.1162494 (published online 25 September 2008). Okita, K. Science doi:10.1126/science.1164270 (published online 9 October 2008).
Stem cells: At home with neural stem cells
Confocal imaging reveals details of how the niche regulates the adult neural stem cells within the walls of the lateral ventricle.
http://ealerts.nature.com/cgi-bin24/DM/y/eoEZ0Xztnp0JEp0B8Iu0Ea
Mirzadeh, Z. et al. Cell Stem Cell 3, 265-278 (2008)
Tavazoie, M. et al.Cell Stem Cell 3, 279-288 (2008)
Shen, Q. et al.. Cell Stem Cell 3, 289-300 (2008)
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Nature Reports Stem Cells is an interactive forum for stem cell scientists and other stakeholders to communicate about the research, policy, ethics, business and medicine of stem cell science. And it's all free!
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