November 2008 Volume 9 Number 11
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Nature Reviews Genetics and Nature Genetics
A Look at Next-Generation Sequencing Technologies
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Nature Review Molecular Cell Biology
Focus on Cell Polarity
Cell polarization is crucial for the development
of unicellular and multicellular organisms, and
is achieved through the coordinated actions of
signalling pathways, membrane trafficking mechanisms
and cytoskeletal dynamics. This special Focus aims
to capture the status quo of cell polarity research
in a range of different systems.
The Focus content is FREE during the month of November.
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This month's FEATURED article:
Crosstalk between small GTPases and polarity proteins in cell polarization
Sandra Iden and John G. Collard
p846 | doi:10.1038/nrm2521
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8QW0El
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From the editors
p821 | doi:10.1038/nrm2543
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8QX0Em
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RESEARCH HIGHLIGHTS
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Cell polarity: Sticky poles
p823 | doi:10.1038/nrm2534
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8QY0En
Development: A force to be reckoned with
p824 | doi:10.1038/nrm2539
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8QZ0Eo
Calcium: An effective get-together
p824 | doi:10.1038/nrm2540
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qa0Ev
WEB WATCH
A simple structure search
p824 | doi:10.1038/nrm2541
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qb0Ew
IN BRIEF
Cell polarity | Cell polarity | Protein degradation
p825 | doi:10.1038/nrm2542
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qc0Ex
Lipid metabolism: Treasure hunt in fat
p826 | doi:10.1038/nrm2533
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qd0Ey
Membrane trafficking: Recycling integrins
p826 | doi:10.1038/nrm2537
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qe0Ez
Molecular motors: Feeling the tension in every step
p827 | doi:10.1038/nrm2532
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qf0E1
Gene expression: Coming in waves
p828 | doi:10.1038/nrm2535
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qg0E2
Cell polarity: Numb localization nailed
p828 | doi:10.1038/nrm2538
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qh0E3
AN INTERVIEW WITH...
Philip Leder
p830 | doi:10.1038/nrm2536
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qi0E4
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Focus on: Cell polarity
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REVIEWS
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Coordinated protein sorting, targeting and distribution in polarized cells
Ira Mellman and W. James Nelson
p833 | doi:10.1038/nrm2525
Polarization requires the coordinated interaction of three machineries
that modify the basic mechanisms of intracellular protein trafficking and
distribution. The integration of these mechanisms into a complex and dynamic
network is crucial for normal tissue function and is often defective in
disease states.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qj0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qk0E6
Crosstalk between small GTPases and polarity proteins in cell polarization
Sandra Iden and John G. Collard
p846 | doi:10.1038/nrm2521
Conserved proteins of the partitioning defective (PAR), Scribble and
Crumbs complexes guide the establishment of cell polarity in various
organisms. Small GTPases have also been implicated in cell polarization.
How do the polarity complexes and the small GTPases coordinate cellular
polarization in different cell types?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Ql0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qm0E8
Beyond polymer polarity: how the cytoskeleton builds a polarized cell
Rong Li and Gregg G. Gundersen
p860 | doi:10.1038/nrm2522
Actin and microtubules are dynamic polar polymers that are well suited
for providing the structural basis for cell polarity. The actin
cytoskeleton generally drives symmetry breaking, whereas microtubules
control polarity maintenance. These events are coordinated by bidirectional
crosstalk between actin and microtubules.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qn0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qo0EB
Organelle positioning and cell polarity
Michel Bornens
p874 | doi:10.1038/nrm2524
The positioning of each cytoskeletal or membrane organelle must be coupled
to that of other organelles in order to contribute efficiently to cell polarity.
The non-random positioning of organelles is preserved and transmitted
through cell division.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qp0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qq0ED
From cells to organs: building polarized tissue
David M. Bryant and Keith E. Mostov
p887 | doi:10.1038/nrm2523
Tissue structures and shapes can be formed by organizing groups of cells
into different polarized arrangements and by coordinating their polarity
in space and time. Conserved design principles that underlie tissue
polarity are emerging from studies of model organisms and tissues.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qr0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qs0EF
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PERSPECTIVES
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OPINION
Turning anti-ageing genes against cancer
Valter D. Longo, Michael R. Lieber and Jan Vijg
p903 | doi:10.1038/nrm2526
Proto-oncogenic pathways, including the insulin-like growth factor-I (IGF-I),
Ras and AKT/PKB pathways, have recently been implicated in the ageing process. I
n simple organisms, proto-oncogene homologues increase DNA damage,
whereas in mice they increase cancer incidence. So, can we prevent cancer
by chronic downregulation of pro-ageing pathways?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qt0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qu0EH
OPINION
Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
Helfrid Hochegger, Shunichi Takeda and Tim Hunt
p910 | doi:10.1038/nrm2510
Cell-cycle transitions in higher eukaryotes are regulated by different
cyclin-dependent kinases (CDKs) and cyclins. Recent work using
gene-targeted mice has led to a revision of this model and revealed
overlapping and essential roles of different CDKs and cyclins.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qv0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qw0EJ
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CORRESPONDENCE
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Correspondence: Exocytosis provides the membrane for protrusion, at
least in migrating fibroblasts
Mark S. Bretscher
p916 | doi:10.1038/nrm2419-c3
http://ealerts.nature.com/cgi-bin24/DM/y/eoMZ0Xztnp0Hjf0B8Qx0EK
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