9 October 2008 Volume 455 Number 7214, pp707-834
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Web Focus: Malaria Parasites
Malaria claims a significant number of lives worldwide,
estimated at around 1 Million each year. The genome
sequence of the most prominent human parasite Plasmodium
falciparum was published in Nature in 2002. We are now
proud to present the genome sequences of two additional
human parasites, P. vivax and P. knowlesi along with a
review article discussing the scientific discoveries
that have been aided by the sequence information.
Click here to access selected content free online.
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EDITORIALS
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Malaria's watershed p707
Malaria's moment has come, but success in control, let alone
eradication, demands a renewed commitment to basic research.
doi:10.1038/455707a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Pz0Ek
The Red List still matters pp707-708
And the IUCN has more to offer than just data on the nearly extinct.
doi:10.1038/455707b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7P10EX
Beta blockers? p708
Proprietary data formats may be legally defensible but open standards
can be a better spur for innovation.
doi:10.1038/455708a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7P20EY
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RESEARCH HIGHLIGHTS
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Human biology: Bird's eye view p710
doi:10.1038/455710a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7P30EZ
Cosmology: Dark limit p710
doi:10.1038/455710b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7P40Ea
Biomechanics: Fungal ballistics p710
doi:10.1038/455710c
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7P50Eb
Zoology: Boomerang bluefins p710
doi:10.1038/455710d
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7P60Ec
Physics: Light squeezing p710
doi:10.1038/455710e
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7P70Ed
Organic chemistry: State benefits pp710-711
doi:10.1038/455710f
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7P80Ee
Geosciences: The melting ocean p711
doi:10.1038/455711a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QA0Eo
Phylogeography: Viking mice p711
doi:10.1038/455711b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QB0Ep
Microbiology: Half life p711
doi:10.1038/455711c
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QC0Eq
Zoology: Dik dik trick p711
doi:10.1038/455711d
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QD0Er
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JOURNAL CLUB
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Journal club p711
Ben Scheres
doi:10.1038/455711e
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QE0Es
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NEWS
----------------------
Nobel for AIDS virus discovery, finally pp712-713
Medicine prize goes to virus researchers; physics prize given for
symmetry-breaking work.
Alison Abbott and Geoff Brumfiel
doi:10.1038/455712a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QF0Et
Charitable bodies hit by credit crisis pp712-713
But most organizations unaffected as yet.
Geoff Brumfiel
doi:10.1038/455712b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QG0Eu
Kavli invests in institutes pp713-713
Philanthropist instigates second round of funding.
Eric Hand
doi:10.1038/455713a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QH0Ev
Vapour spies to reveal climate clues pp714-715
Isotope analysis will provide new tools for weather modelling.
Jeff Tollefson
doi:10.1038/455714a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QI0Ew
Slime and fleas feature in Ig Nobel awards pp714-715
Tongue-in-cheek prizes recognize improbable research.
Steve Nadis
doi:10.1038/455714b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QJ0Ex
Entire-paper plagiarism caught by software pp715-715
Thousands of 'similarities' found between papers.
Declan Butler
doi:10.1038/455715a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QK0Ey
Change of guard for Australian science pp716-716
Women in top two science posts.
Carina Dennis
doi:10.1038/455716a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QL0Ez
A quarter of mammals face extinction p717
Latest Red List finds 80% of southeast Asian primates are at risk.
Natasha Gilbert
doi:10.1038/455717a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QM0E1
Q&A: The future for Howard Hughes pp718-718
Robert Tjian speaks to Nature about his plans as the new president of
the Howard Hughes Medical Institute.
Erika Check Hayden
doi:10.1038/455718a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QN0E2
Snapshot: The in silico show pp718-718
doi:10.1038/455718b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QO0E3
UK launches department to focus on climate change pp719-719
doi:10.1038/455719a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QP0E4
US academic fleet cuts operations as budget bites pp719-719
doi:10.1038/455719b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QQ0E5
Italy to create biomedical-research funding system pp719-719
doi:10.1038/455719c
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QR0E6
Eli Lilly wins race to take control of ImClone pp719-719
doi:10.1038/455719d
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QS0E7
United States agrees to sell nuclear fuel to India pp719-719
doi:10.1038/455719e
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QT0E8
Wall Street bill boosts renewable energies pp719-719
doi:10.1038/455719f
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QU0EA
----------------------
NEWS FEATURES
----------------------
Collaboration: Group theory pp720-723
What makes a successful team? John Whitfield looks at research that
uses massive online databases and network analysis to come up with
some rules of thumb for productive collaborations.
doi:10.1038/455720a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QV0EB
Soil ecology: What lies beneath pp724-725
More creatures live in soil than any other environment on Earth.
But what are they all doing there? Amber Dance reports on the
world's widest biodiversity.
doi:10.1038/455724a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QW0EC
Profile: What is that smell? pp726-728
Jacek Koziel is a master of odours. On a pig farm in Iowa, he shows
Erik Vance some of the peaks and troughs of life as a human detector.
doi:10.1038/455726a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QX0ED
----------------------
CORRESPONDENCE
----------------------
Science lobbying in Canada needs stepping up p729
Mehrdad Hariri
doi:10.1038/455729a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QY0EE
Playing the system puts self-citation's impact under review p729
James Testa
doi:10.1038/455729b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7QZ0EF
Austria: investigation likely to have serious consequences p729
Guenther Bonn et al.
doi:10.1038/455729c
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qa0EM
As someone wise or funny and probably famous once said ... p729
Neville W. Goodman
doi:10.1038/455729d
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qb0EN
----------------------
COMMENTARY
----------------------
A network solution pp730-731
With the right plan, systems biology can empower drug discovery,
say Adriano Henney and Giulio Superti-Furga. Field leaders have
contributed and now the authors want to hear from you.
doi:10.1038/455730a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qc0EO
----------------------
BOOKS AND ARTS
----------------------
The many faces of carbon pp732-733
An enticing new book ties together the vital roles this element has
in life, the Universe and climate change, explains John Meurig Thomas.
doi:10.1038/455732a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qd0EP
Burning down the house pp732-733
Bill McGuire reviews Global Catastrophic Risks.
doi:10.1038/455732b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qe0EQ
Crisis reading p733
Jenny Meyer reviews books on natural cataclysms.
doi:10.1038/455733a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qf0ER
Painting by night p734
Josie Glausiusz reviews Van Gogh and the Colors of the Night.
doi:10.1038/455734a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qg0ES
Science at the movies pp734-735
Jascha Hoffman reviews Imagine Science Film Festival and CinemaScience.
doi:10.1038/455734b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qh0ET
Neutrinos: wonderful or crass? p735
John Updike's 1960 poem vents frustration at the detached and elusive
quantum particles that have no consideration for our earthly
perceptions, says Martin Kemp.
doi:10.1038/455735a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qi0EU
Hidden treasures: Turin's anatomy museum p736
Some controversial nineteenth-century theories about brain shape and
human nature are revealed by an extensive collection of neuroscience
memorabilia, reports Alison Abbott.
doi:10.1038/455736a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qj0EV
----------------------
ESSAY
----------------------
Meetings that changed the world: Madrid 1995: Diagnosing climate change
pp737-738
John Houghton chaired the tense IPCC meeting without which there would
be no Kyoto Protocol. Here he recalls how science won the day.
doi:10.1038/455737a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qk0EW
----------------------
NEWS AND VIEWS
----------------------
Gerontology: Healthy old age pp739-740
Do longer lives mean that growing numbers of us will spend more time
in a state of high-cost dependency? Evidence from one elderly cohort
suggests that excessive levels of disability are far from inevitable.
Thomas B. L. Kirkwood
doi:10.1038/455739a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Ql0EX
Molecular biology: DNA endgames pp740-741
If it is not repaired efficiently, damage to DNA double strands can
have dire consequences for both the cell and the organism. Given the
gravity of this situation, cells use two pathways to start the process.
Hannah L. Klein
doi:10.1038/455740a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qm0EY
Solid-state physics: Recipe for spin currents pp741-743
Generating currents that rely on the spins of electrons to make
electronic devices requiring less power is both desirable and
daunting. A neat way of creating such currents eases that task.
N. P. Ong
doi:10.1038/455741a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qn0EZ
Neuroscience: Brain's defence against cocaine pp743-744
Long-term exposure to cocaine changes the organization of synaptic
connections within the addiction circuitry of the brain. This process
might protect against the development and persistence of addiction.
L. Judson Chandler and Peter W. Kalivas
doi:10.1038/455743a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qo0Ea
Materials science: Solar cells go round the bend p744
Andrew Mitchinson
doi:10.1038/455744a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qp0Eb
Immunology: Helpful T cells are sticky pp745-747
Prolonged physical interaction between helper T cells and
antibody-producing B cells is crucial for efficient immune
responses. Mutations in a protein that underlies this process
cause human disease.
Elissa K. Deenick and Stuart G. Tangye
doi:10.1038/455745a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qq0Ec
50 & 100 years ago p745
doi:10.1038/455745b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qr0Ed
Developmental biology: Teeth in double trouble pp747-748
Almost all vertebrates have teeth of some sort. But where, in
developmental terms, do teeth come from? Results drawn from
experimental embryology provide an illuminating perspective
on this contentious question.
Georgy Koentges
doi:10.1038/455747a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qs0Ee
Geomorphology: How Tibet might keep its edge pp748-749
The stability of the margins of the Himalayan-Tibetan mountain
belt constitutes a puzzle. Repeated damming of major Tibetan rivers
by glaciers, so controlling river erosion, is a possible explanation.
Lewis A. Owen
doi:10.1038/455748a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qt0Ef
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GWAS Data Analysis & Resequencing GRANT
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=====================================================================
----------------------
REVIEW
----------------------
Malaria research in the post-genomic era pp751-756
Elizabeth Ann Winzeler
doi:10.1038/nature07361
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qu0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qv0Eh
----------------------
CORRIGENDUM
----------------------
Functional metagenomic profiling of nine biomes p830
Elizabeth A. Dinsdale et al.
doi:10.1038/nature07346
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qw0Ei
----------------------
ARTICLES
----------------------
Comparative genomics of the neglected human malaria parasite
Plasmodium vivax pp757-763
Plasmodium vivax infection contributes significantly to malaria
incidence in humans, although the resulting disease is usually milder
than that caused by P. falciparum infection. The P. vivax genome,
with a comparative analysis to the genomes of other Plasmodium
species, is now presented, providing insights into the distinct
biologies of this group of parasites.
Jane M. Carlton et al.
doi:10.1038/nature07327
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qx0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qy0Ek
SAP-controlled T-B cell interactions underlie germinal centre
formation pp764-769
Signalling of the lymphocyte activation molecule associated protein
SAP is required for formation of germinal centres, which in turn
regulate the production of antibodies. People with mutations in SAP
suffer from immunodeficiency. This work shows that SAP deficient
T cells are unable to interact with and provide help to antigen
specific B cells and fail to be recruited into germinal centres.
Hai Qi et al.
doi:10.1038/nature07345
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qz0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Q10EY
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
p770
Homologous recombination requires the production of single stranded
DNA tails with a 3' end. However, the most obvious candidate for an
exonuclease that would function in this process, the Mre11 complex,
generates 5' tailed molecules. This work provides some clarity about
how end resection occurs. The cell uses a two step process in which
a short oligo is first removed from one strand by the Mre11 complex,
and then the exonuclease ExoI and helicase Sgs1 load onto this
substrate to generate the 3' tailed molecule.
Eleni P. Mimitou & Lorraine S. Symington
doi:10.1038/nature07312
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Q20EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Q30Ea
----------------------
LETTERS
----------------------
The formation and assembly of a typical star-forming galaxy at redshift
z~3 pp775-777
This paper reports observations of a typical star forming galaxy at
z~3.07, with a linear resolution of ~100 parsecs. A well ordered
compact source in which molecular gas is being converted efficiently
into stars is found, likely to be assembling a spheroidal bulge
similar to those seen in spiral galaxies at the present day.
Daniel P. Stark et al.
doi:10.1038/nature07294
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Q40Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Q50Ec
Observation of the spin Seebeck effect pp778-781
This paper examines the idea that a metallic magnet in a temperature
gradient effectively works like a thermocouple for spin voltage;
the Seebeck coefficients will be different for electrons with spin
up and those with spin down, so that a spin voltage is generated,
driving different amounts of flow for spin up and spin down electrons.
A new spin detection technique is used to observe this effect for the
first time, and it is shown that it is possible to use the spin Seebeck
effect to obtain pure spin currents over millimetre distances.
K. Uchida et al.
doi:10.1038/nature07321
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Q60Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Q70Ee
High-temperature interface superconductivity between metallic and
insulating copper oxides pp782-785
This paper reports superconductivity in bilayers consisting of an
insulator (La2CuO4) and a metal (La1.55Sr0.45CuO4), neither of which
is superconducting in itself. In bilayers Tc is either ~15 K or ~30 K,
depending on the layering sequence. This highly robust phenomenon is
confined within 2–3 nm from the interface. If such a bilayer is exposed
to ozone, Tc exceeds 50 K and this enhanced superconductivity is also
shown to originate from the interface layer about 1–2 unit cell thick.
A. Gozar et al.
doi:10.1038/nature07293
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Q80Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RA0Ep
Tibetan plateau river incision inhibited by glacial stabilization of
the Tsangpo gorge pp786-789
A considerable amount of research has focused on how and when the
Tibetan plateau formed, but far less inquiry has addressed the controls
on river incision into the plateau itself. It is proposed that
Quaternary depression of the regional equilibrium line altitude,
where annual glacier mass gain equals mass loss, was sufficient to
repeatedly form moraine dams on major rivers and substantially inhibit
river incision into the southeastern edge of the Tibetan plateau through
the coupled effects of upstream impoundment and interglacial aggradation.
Oliver Korup and David R. Montgomery
doi:10.1038/nature07322
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RB0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RC0Er
Central role of detachment faults in accretion of slow-spreading
oceanic lithosphere pp790-794
Oceanic detachment faults are associated with one of two contrasting
modes of accretion at mid ocean ridges and can accommodate extension
for millions of years. An examination of ~2500 km of the mid Atlantic
ridge is presented, which reveals that asymmetrical accretion
surprisingly occurs along half of the studied ridge section.
Much of the variability in seafloor morphology, seismicity and
basalt chemistry found along slow spreading ridges may thus be
attributed to the frequent involvement of detachment faults
in oceanic lithospheric accretion.
J. Escartin et al.
doi:10.1038/nature07333
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RD0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RE0Et
Dual epithelial origin of vertebrate oral teeth p795
This work details that the oral teeth of a vertebrate are derived from
both the ectoderm and endoderm, and also demonstrates teeth with a
mixed ectoendodermal origin. This suggests that the role of the neural
crest mesenchyme is dominant of the role of the epithelia in tooth
formation. The evolutionary implications are that a driving force of
teeth evolution was the tooth forming capacity of neural crest cells,
regardless of the directionality of the influx of the epithelium.
Vladimír Soukup, Hans-Henning Epperlein, Ivan Horácek & Robert Cerny
doi:10.1038/nature07304
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RF0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RG0Ev
The genome of the simian and human malaria parasite
Plasmodium knowlesi pp799-803
Plasmodium knowlesi is a natural pathogen of macaques where it causes
disease similar to human malaria. More recently it has been realized
that P. knowlesi also infects and causes disease in humans. Its genome
has now been sequenced, providing insight into the biology of this parasite.
A. Pain et al.
doi:10.1038/nature07306
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RH0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RI0Ex
Vancomycin-resistant enterococci exploit antibiotic-induced innate
immune deficits p804
Commensal bacteria play a protective role in limiting the outgrowth of
potentially harmful antibiotic resistant bacteria by inducing
intestinal expression of the antimicrobial lectin RegIIIgamma. Treatment
with antibiotics is shown to increase infection with resistant bacteria
by compromising intestinal innate immunity.
Katharina Brandl et al.
doi:10.1038/nature07250
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RJ0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RK0Ez
ATP drives lamina propria TH17 cell differentiation p808
TH17 cells in the intestinal lamina propria are shown to be induced in
response to the microbiota. Commensal bacteria derived ATP is shown to
activate a subset of intestinal dendritic cells to induce IL 6 production
and TGF-beta activation, thereby promoting the local differentiation of TH17 cells.
Koji Atarashi et al.
doi:10.1038/nature07240
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RL0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RM0E2
The deubiquitinylation and localization of PTEN are regulated by a
HAUSP–PML network p813
HAUSP is identified as the enzyme responsible for PTEN deubiquitination,
an activity that regulates the cellular localization and function of
PTEN. This role of HAUSP is antagonized by PML, another tumour
suppressor. PML function is disrupted in promeyelocytic leukaemia,
and drugs that are effective in treating this form of leukaemia are
found to impinge on PTEN function, by affecting PML and HAUSP.
Min Sup Song et al.
doi:10.1038/nature07290
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RN0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RO0E4
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by
a base-flipping mechanism p818
UHRF1 (or Np95/ICBP90) facilitates the loading of DNA methyltransferase
1 onto hemi methylated CpG sequences during DNA replication to enable
the faithful maintenance of DNA methylation patterns. This is one of
three papers in this issue that describes crystal structures of the
SRA domain of UHRF1 bound to DNA containing a hemi methylated CpG site.
The methyl cytosine is flipped out of the DNA helix and inserted into
a binding pocket on the SRA domain.
Kyohei Arita, Mariko Ariyoshi, Hidehito Tochio, Yusuke Nakamura
& Masahiro Shirakawa
doi:10.1038/nature07249
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RP0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RQ0E6
Structural basis for recognition of hemi-methylated DNA by
the SRA domain of human UHRF1 p822
UHRF1 (or Np95/ICBP90) facilitates the loading of DNA methyltransferase
1 onto hemi methylated CpG sequences during DNA replication to enable
the faithful maintenance of DNA methylation patterns. This is one of
three papers in this issue that describes crystal structures of the
SRA domain of UHRF1 bound to DNA containing a hemi methylated CpG site
. The methyl cytosine is flipped out of the DNA helix and inserted
into a binding pocket on the SRA domain.
George V. Avvakumov et al.
doi:10.1038/nature07273
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RR0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RS0E8
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix p826
UHRF1 (or Np95/ICBP90) facilitates the loading of DNA methyltransferase
1 onto hemi methylated CpG sequences during DNA replication to enable
the faithful maintenance of DNA methylation patterns. This is one of
three papers in this issue that describes crystal structures of the
SRA domain of UHRF1 bound to DNA containing a hemi methylated CpG site.
The methyl cytosine is flipped out of the DNA helix and inserted into
a binding pocket on the SRA domain.
Hideharu Hashimoto, John R. Horton, Xing Zhang, Magnolia Bostick,
Steven E. Jacobsen & Xiaodong Cheng
doi:10.1038/nature07280
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RT0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RU0EB
----------------------
CORRIGENDUM
----------------------
Functional metagenomic profiling of nine biomes p830
Elizabeth A. Dinsdale et al.
doi:10.1038/nature07346
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Qw0Ei
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p831
The art of setting up a lab for the first time.
Gene Russo
doi:10.1038/nj7214-831a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RV0EC
Career View
James Pendlebury, chief executive, Forest Research, Alice Holt Lodge,
Farnham, UK. p832
A career in forestry, informed by materials science.
Virginia Gewin
doi:10.1038/nj7214-832a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RW0ED
Developing generic skills p832
Generic-skills course offers key insights.
Paul Smaglik
doi:10.1038/nj7214-832b
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RX0EE
Research growing pains p832
A new position brings hope and anxiety.
Zachary Lippman
doi:10.1038/nj7214-832c
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RY0EF
----------------------
FUTURES
----------------------
The picture of Oscar X p834
An image of the future.
Anna Batistatou and Konstantinos Charalabopoulos
doi:10.1038/455834a
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7RZ0EG
----------------------
ADVANCE ONLINE PUBLICATION
----------------------
08 October 2008
Generation of pluripotent stem cells from adult human testis
Sabine Conrad et al.
doi:10.1038/nature07404
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Ra0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rb0EO
The ion pathway through the opened Na+,K+-ATPase pump
Ayako Takeuchi, Nicolás Reyes, Pablo Artigas and David C. Gadsby
doi:10.1038/nature07350
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rc0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rd0EQ
Stereocilin-deficient mice reveal the origin of cochlear waveform distortions
Elisabeth Verpy et al.
doi:10.1038/nature07380
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Re0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rf0ES
05 October 2008
A key role for autophagy and the autophagy gene Atg16l1 in mouse and
human intestinal Paneth cells
Ken Cadwell et al.
doi:10.1038/nature07416
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rg0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rh0EU
A fasting inducible switch modulates gluconeogenesis via
activator/coactivator exchange
Yi Liu et al.
doi:10.1038/nature07349
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Ri0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rj0EW
Guarding the gateway to cortex with attention in visual thalamus
Kerry McAlonan, James Cavanaugh & Robert H. Wurtz
doi:10.1038/nature07382
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rk0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rl0EY
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced
IL-1beta production
Tatsuya Saitoh et al.
doi:10.1038/nature07383
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rm0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B7Rn0Ea
=====================================================================
Nature Reviews Microbiology
October 2008 - Focus on Symbiosis
Microbial symbioses include beneficial, harmful
and neutral relationships and are important in
animal and plant health, immunity and disease,
and in ecology and the environment. This special
Focus issue highlights exciting advances in our
understanding of partnerships between organisms
and their environments.
This FREE focus can be accessed online at:
http://ealerts.nature.com/cgi-bin24/DM/y/en4v0Xztnp0HjB0B5R50Eb
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